黑料网

kills about 300,000 Americans each year and is the leading cause of loss of disability-adjusted life years in hospital patients around the world, making the disease a major public health concern. Venous thrombosis can also lead to dangerous complications, such as pulmonary embolism and post-thrombotic syndrome. Venous thrombosis occurs when form in veins; this is often due to abnormal interactions between three components: . We have helped to elucidate specific pathobiological mechanisms contributing to venous thrombosis, including specific roles for , , , and . We are interested in further discerning mechanisms and potential therapeutic targets to determine new and more effective treatments.

Figure: Interplay between abnormalities in blood components, the vasculature, and blood flow contribute to the development of venous thrombosis. Abbreviations: TM, thrombomodulin; EPCR, endothelial protein C receptor; II, prothrombin; IIa, thrombin; TF, tissue factor; Fgn, fibrinogen; RBC, red blood cells