Research Radiation Core Facility /rrcf Tue, 06 May 2025 22:02:22 +0000 en-US hourly 1 RCF 2025 Research Forum: Cesium-137 vs X-ray /rrcf/2025/05/rcf-2025-research-forum/ Mon, 05 May 2025 16:35:05 +0000 /rrcf/?p=2458 Read more]]>

Our first Research Forum is scheduled to take place on the afternoon of May 29, 2025 in Marsico Hall. This year’s forum will feature research presentations from three ºÚÁÏÍø labs led by Drs. Barbara Vilen, Brian Miller, and Martina Kovarova. Each lab conducted a comparison study evaluating radiobiological effects using either 137Cs-based irradiator or X-ray irradiator in cells or live animals. Funding for these comparison studies was provided by Sandia National Laboratories and the National Nuclear Security Administration’s Office of Radiological Security. The scientific data reported from these laboratories will guide us how to replace the Cs-based irradiator with x-ray irradiator.  In addition, a technical talk on radiation dosimetry tools will be given. Everyone is welcome to attend the forum and join our discussions.

Date: May 29, 2025
Time: 1:00 – 3:00 PM
Location: Marsico Hall, Room 6004
Coffee and snacks will be provided.
(For researchers from outside of ºÚÁÏÍø, please to receive the Webinar link.)

Time

Speaker

Title

1:00 – 1:30 PM Xinyun Bi, Ph.D.
Barbara Vilen, Ph.D.
Compare Cs irradiation to X-ray in producing apoptotic blebs for use in forming IgG-ICs
1:30 – 2:00 PM Alexander Bastian, Ph.D.
Brian Miller, MD Ph.D.
Evaluating the immune reconstitution and radio-resistance across immune cell subsets in X-Ray and Cs irradiation
2:00 – 2:30 PM Genevieve Doyon, Ph.D.
Martina Kovarova, Ph.D.
Evaluation of X-ray irradiation as a replacement for Cs irradiation for preparation of humanized mice
2:30 – 2:45 PM Hong Yuan, Ph.D.
Sha Chang, Ph.D.
How to measure radiation dose: tools of radiation dosimetry
2:45 – 3:00 PM Discussion
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RCF Pilot Project Awards /rrcf/2025/05/rcf-pilot-project-awards/ Mon, 05 May 2025 16:06:58 +0000 /rrcf/?p=2453 Read more]]>

In May 2024, the Radiation Core Facility received a grant from Sandia National Laboratories and the National Nuclear Security Administration’s Office of Radiological Security to support research comparing the radiobiological effects of 137Cs irradiators and x-ray irradiators. The 137Cs irradiator has long been used in various radiation-related research studies. However, due to security concerns associated with its radioactive source, there is a growing movement to transition to x-ray irradiators. While several studies have demonstrated the feasibility of this replacement, the radiobiological equivalency between the two radiation sources needs further validation in a wider scope. This grant provides an opportunity for researchers at the University of North Carolina (ºÚÁÏÍø) to conduct comparative studies evaluating the radiobiological effects of the two radiation sources specifically related to their research focus, either in cells and animal models. The three participating awardees and their respective project titles are listed below.

Project Title

Investigator

Determining the number of hematopoietic stem cells that reconstitute the immune system between X-ray and Cs irradiation using genetic barcodes Brian Miller, MD, Ph.D.
Comparing Cs irradiation to X-rays in producing apoptotic blebs for use in forming IgG-ICs Barbara Vilen, Ph.D.
Evaluation of X-ray irradiation as a replacement for Cs irradiation for preparation of humanized mice Martina Kovarova, Ph.D.

 

Sandia National Laboratories Office of Radiological Security

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