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In May 2024, the Radiation Core Facility received a grant from Sandia National Laboratories and the National Nuclear Security Administration’s Office of Radiological Security to support research comparing the radiobiological effects of 137Cs irradiators and x-ray irradiators. The 137Cs irradiator has long been used in various radiation-related research studies. However, due to security concerns associated with its radioactive source, there is a growing movement to transition to x-ray irradiators. While several studies have demonstrated the feasibility of this replacement, the radiobiological equivalency between the two radiation sources needs further validation in a wider scope. This grant provides an opportunity for researchers at the University of North Carolina (ºÚÁÏÍø) to conduct comparative studies evaluating the radiobiological effects of the two radiation sources specifically related to their research focus, either in cells and animal models. The three participating awardees and their respective project titles are listed below.

Project Title

Investigator

Determining the number of hematopoietic stem cells that reconstitute the immune system between X-ray and Cs irradiation using genetic barcodes Brian Miller, MD, Ph.D.
Comparing Cs irradiation to X-rays in producing apoptotic blebs for use in forming IgG-ICs Barbara Vilen, Ph.D.
Evaluation of X-ray irradiation as a replacement for Cs irradiation for preparation of humanized mice Martina Kovarova, Ph.D.

 

Sandia National Laboratories Office of Radiological Security