{"id":1399,"date":"2020-10-27T20:20:02","date_gmt":"2020-10-28T00:20:02","guid":{"rendered":"https:\/\/www.med.unc.edu\/radiology\/2020\/10\/27\/z-li-r01-to-develop-radiosensitizer-to-boost-radiotherapy-in-non-small-cell-lung-cancer\/"},"modified":"2024-03-27T10:52:30","modified_gmt":"2024-03-27T14:52:30","slug":"z-li-r01-to-develop-radiosensitizer-to-boost-radiotherapy-in-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/radiology\/2020\/10\/z-li-r01-to-develop-radiosensitizer-to-boost-radiotherapy-in-non-small-cell-lung-cancer\/","title":{"rendered":"Z. Li: R01 Funding Radiosensitizer Development to Advance Non-Small Cell Lung Cancer Radiotherapy"},"content":{"rendered":"

The Department congratulates Professor of Radiology Zibo Li, PhD<\/strong>, for receiving an NIH Research Project $2.5M (R01) grant funding his proposal, entitled, \u201cThe development of novel radiation-sensitizer based on ultra-small carbon dots.\u201d<\/em>\u00a0 This multi-institutional project involves University of Georgia Associate Professor of Chemistry Jin Xie, PhD and ºÚÁÏÍø-Chapel Hill physician-scientists Andrew Wang, MD (Urologic Oncology) and Associate Professor of Radiology Yueh Lee, MD, PhD (Neuroradiology). Over five years (7\/15\/2020 \u2013 6\/30\/2025), the long-time Director of ºÚÁÏÍø\u2019s Cyclotron and Radiochemistry Research Program and his collaborators aim to develop a new category of radiosensitizer using an ultra-small nanoparticle — metal intarcalated carbon dots — (M@Cdots) \u2013 to enhance radiotherapy (RT) in non-small cell lung cancer (NSCLC) patient treatment and outcomes.\u00a0 \"\"<\/p>\n

For early-stage NSCLC patient treatment and management, a range of radiation sensitizers used concurrently with radiation (RT) are viable alternatives to other methods, such as lobectomy and lymph node dissection. Unfortunately, radiosensitizers used alone can cause severe systematic toxicities despite enhancing tumor-killing efficacy. Li’s team proposes to develop a new category of radiosensitizer using ultra-small, interacalated carbon dots (M@Cdots) to achieve enhanced cancer-killing effect with minimal systemic toxicity.\u00a0 The study hypothesizes affixing neurotensin (NTS) to the surface of M@Cdots improves tumor specificity. Added to efficient dose enhancement, minimal metal leakage, excellent tumor selectivity, sufficient intratumoral penetration and efficient renal clearance, this application of ultra-small nanoparticles produces a new category of radiation-sensitizer causing minimal systemic toxicities.<\/p>\n

If successful, development of these radiosensitizers with reduced radiation doses will cause minimal systemic toxicities that lead to greatly improved outcomes when used concurrently with radiation therapy (RT). If successfully applied to RT for NSCLC, this methodology could be extended to studying treatment of other cancer types, such as head and neck, breast and prostate cancer.<\/p>\n

Li notes: \u201cThrough this collaborative research, we may seamlessly integrate molecular imaging with targeted therapy, which would eventually lead to personalized medicine for lung cancer patient and beyond.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

The Department congratulates Professor of Radiology Zibo Li, PhD, for receiving an NIH Research Project $2.5M (R01) grant funding his proposal, entitled, \u201cThe development of novel radiation-sensitizer based on ultra-small carbon dots.\u201d\u00a0 This multi-institutional project involves University of Georgia Associate Professor of Chemistry Jin Xie, PhD and ºÚÁÏÍø-Chapel Hill physician-scientists Andrew Wang, MD (Urologic Oncology) … Read more<\/a><\/p>\n","protected":false},"author":17488,"featured_media":458,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[83,90,91,84,89,92],"tags":[94,95,96],"class_list":["post-1399","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-department-news","category-fall-2020","category-homepage-news","category-images-newsletter","category-images-newsletter-images-newsletter","category-in-the-news","tag-fall-2020","tag-images-newsletter","tag-in-the-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/radiology\/wp-content\/uploads\/sites\/1384\/2023\/10\/Zibo-Li-RESIZED.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/radiology\/wp-content\/uploads\/sites\/1384\/2023\/10\/Zibo-Li-RESIZED.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/radiology\/wp-content\/uploads\/sites\/1384\/2023\/10\/Zibo-Li-RESIZED.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/radiology\/wp-content\/uploads\/sites\/1384\/2023\/10\/Zibo-Li-RESIZED.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/radiology\/wp-content\/uploads\/sites\/1384\/2023\/10\/Zibo-Li-RESIZED-150x150.jpg","featured_image_alt":"Asian male with short spiky brown hair and brown eyes smiling at the camera. He is wearing a light blue open-collar button-down shirt. He is standing against a blue backdrop.","category_details":[{"name":"Department News","link":"https:\/\/www.med.unc.edu\/radiology\/category\/department-news\/"},{"name":"Fall 2020","link":"https:\/\/www.med.unc.edu\/radiology\/category\/images-newsletter\/images-newsletter-images-newsletter\/fall-2020\/"},{"name":"Homepage News","link":"https:\/\/www.med.unc.edu\/radiology\/category\/homepage-news\/"},{"name":"Images Newsletter","link":"https:\/\/www.med.unc.edu\/radiology\/category\/images-newsletter\/"},{"name":"Images Newsletter","link":"https:\/\/www.med.unc.edu\/radiology\/category\/images-newsletter\/images-newsletter-images-newsletter\/"},{"name":"IN THE NEWS","link":"https:\/\/www.med.unc.edu\/radiology\/category\/department-news\/in-the-news\/"}],"tag_details":[{"name":"Fall 2020","link":"https:\/\/www.med.unc.edu\/radiology\/tag\/fall-2020\/"},{"name":"Images Newsletter","link":"https:\/\/www.med.unc.edu\/radiology\/tag\/images-newsletter\/"},{"name":"IN THE NEWS","link":"https:\/\/www.med.unc.edu\/radiology\/tag\/in-the-news\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/posts\/1399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/users\/17488"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/comments?post=1399"}],"version-history":[{"count":7,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/posts\/1399\/revisions"}],"predecessor-version":[{"id":6168,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/posts\/1399\/revisions\/6168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/media\/458"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/media?parent=1399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/categories?post=1399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/radiology\/wp-json\/wp\/v2\/tags?post=1399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}