Department of Psychiatry /psych/ Mon, 09 Jun 2025 18:23:12 +0000 en-US hourly 1 Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories https://pubmed.ncbi.nlm.nih.gov/40406207/#new_tab Mon, 09 Jun 2025 18:23:12 +0000 /psych/?p=17536 Via usual smartphone use following trauma exposure, this study identified language markers associated with patient-reported severity and change in severity for multiple symptoms. Using language markers as a proxy for the status of and changes in specific symptoms supports efficient remote health status monitoring and can provide clinicians with valuable real-time insights into health, functioning, …

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Via usual smartphone use following trauma exposure, this study identified language markers associated with patient-reported severity and change in severity for multiple symptoms. Using language markers as a proxy for the status of and changes in specific symptoms supports efficient remote health status monitoring and can provide clinicians with valuable real-time insights into health, functioning, and recovery. These insights can be leveraged to guide targeted interventions tailored to individual trauma survivors.

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Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD https://pubmed.ncbi.nlm.nih.gov/40319171/#new_tab Mon, 09 Jun 2025 18:21:16 +0000 /psych/?p=17534 Hyperarousal symptoms such as jumpiness and over-alertness are central features of posttraumatic stress disorder (PTSD), and are partly explained by hyper-reactivity of the right amygdala, a brain region involved in emotional learning. In the current study, we found that people who showed right amygdala hyper-reactivity shortly after trauma were more likely to experience future chronic …

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Hyperarousal symptoms such as jumpiness and over-alertness are central features of posttraumatic stress disorder (PTSD), and are partly explained by hyper-reactivity of the right amygdala, a brain region involved in emotional learning. In the current study, we found that people who showed right amygdala hyper-reactivity shortly after trauma were more likely to experience future chronic PTSD symptom severity, confirming prior findings observed in much smaller samples. This strengthens growing evidence that hyperarousal may be a trait-like risk factor for PTSD. However, we also observed that the early high amygdala response may “burn out” over time, resulting in a state of low threat responsiveness 6 months following trauma. The findings will aid future efforts shape the timing of interventions to facilitate PTSD recovery.

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Obsessive-compulsive disorder symptoms in an adult cystic fibrosis population https://pubmed.ncbi.nlm.nih.gov/40179605/#new_tab Mon, 09 Jun 2025 18:20:03 +0000 /psych/?p=17532 In a survey of adults with cystic fibrosis attending a large, academic medical center, 32% scored high enough on a standardized screening tool to suggest they probably have obsessive-compulsive disorder. This rate is much higher than the rate in the general population and 2-3 times higher than in other populations of adults with chronic illness.

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In a survey of adults with cystic fibrosis attending a large, academic medical center, 32% scored high enough on a standardized screening tool to suggest they probably have obsessive-compulsive disorder. This rate is much higher than the rate in the general population and 2-3 times higher than in other populations of adults with chronic illness.

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Motor Assisted Commutator to Harness Electronics in Tethered Experiments https://pubmed.ncbi.nlm.nih.gov/40324877/ Mon, 09 Jun 2025 18:19:01 +0000 /psych/?p=17530 We developed a Motor Assisted Commutator to Harness Electronics in Tethered Experiments (MACHETE), an open-source device that helps behavioral neuroscientists retain naturalistic behavior during tethered, freely moving experiments in mice. We were particularly interested in freely-moving experiments relevant to studying arousal disorders, including the open field test, splash test, and 3 chamber assay.

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We developed a Motor Assisted Commutator to Harness Electronics in Tethered Experiments (MACHETE), an open-source device that helps behavioral neuroscientists retain naturalistic behavior during tethered, freely moving experiments in mice. We were particularly interested in freely-moving experiments relevant to studying arousal disorders, including the open field test, splash test, and 3 chamber assay.

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Prepronociceptin-expressing neurons in the bed nucleus of the stria terminalis signal escape behavior https://www.sciencedirect.com/science/article/pii/S2667174325000928#new_tab Mon, 09 Jun 2025 18:17:17 +0000 /psych/?p=17528 Anxiety disorders arise when the brain’s response to threats become too intense or persists when not needed, leading to maladaptive behaviors and excessive arousal. We found that specialized arousal neurons in a brain region called the bed nucleus of the stria terminalis activate when mice escape an aversive stimulus, offering clues to how these neurons …

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Anxiety disorders arise when the brain’s response to threats become too intense or persists when not needed, leading to maladaptive behaviors and excessive arousal. We found that specialized arousal neurons in a brain region called the bed nucleus of the stria terminalis activate when mice escape an aversive stimulus, offering clues to how these neurons might misfire in anxiety.

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SimNorth: A novel contrastive learning approach for clustering prenatal ultrasound images https://pmc.ncbi.nlm.nih.gov/articles/PMC12127854/#new_tab Mon, 09 Jun 2025 18:15:11 +0000 /psych/?p=17526 This paper presents SimNorth, an unsupervised deep learning method for organizing non-standard fetal ultrasound images. By learning feature embeddings using a novel contrastive loss and clustering similar anatomical structures, SimNorth outperforms existing methods like Autoencoders, MoCo, and SimCLR in identifying meaningful image groups.

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This paper presents SimNorth, an unsupervised deep learning method for organizing non-standard fetal ultrasound images. By learning feature embeddings using a novel contrastive loss and clustering similar anatomical structures, SimNorth outperforms existing methods like Autoencoders, MoCo, and SimCLR in identifying meaningful image groups.

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Xylazine potentiates the interoceptive effects of fentanyl in male and female rats https://pubmed.ncbi.nlm.nih.gov/40383852/#new_tab Mon, 09 Jun 2025 18:13:48 +0000 /psych/?p=17524 Xylazine, an adulterant increasingly found in the illicit opioid drug supply, enhances the interoceptive (subjective) effects of lower doses of fentanyl in rats. These results in rats align with reports from people who use drugs and may be used to better understand the mechanism of the effects of xylazine on fentanyl perception.

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Xylazine, an adulterant increasingly found in the illicit opioid drug supply, enhances the interoceptive (subjective) effects of lower doses of fentanyl in rats. These results in rats align with reports from people who use drugs and may be used to better understand the mechanism of the effects of xylazine on fentanyl perception.

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Switching state to engage and sustain attention: Dynamic synchronization of the frontoparietal network https://pubmed.ncbi.nlm.nih.gov/40389123/#new_tab Mon, 09 Jun 2025 18:12:04 +0000 /psych/?p=17522 Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

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Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

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Switching state to engage and sustain attention: Dynamic synchronization of the frontoparietal network https://pubmed.ncbi.nlm.nih.gov/40389123/#new_tab Mon, 09 Jun 2025 18:05:26 +0000 /psych/?p=17520 Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

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Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

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Myra Daniel celebrates 50 years with Psychiatry! /psych/myra-daniel-celebrates-50-years-with-unc-psychiatry/ Wed, 04 Jun 2025 15:14:15 +0000 /psych/?p=17481 Myra Daniel, currently serving as AHEC and Medical Student Coordinator, celebrates her 50th year with Psychiatry! Since August 1974, Myra has had multiple roles working with faculty, residents, and medical students alike. Myra’s career developed from helping to research and edit manuscripts to be submitted for publications for psychanalysts Drs. David Raft and Jeff … Read more

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Myra DanielMyra Daniel, currently serving as AHEC and Medical Student Coordinator, celebrates her 50th year with Psychiatry!

Since August 1974, Myra has had multiple roles working with faculty, residents, and medical students alike. Myra’s career developed from helping to research and edit manuscripts to be submitted for publications for psychanalysts Drs. David Raft and Jeff Andresen, assisting with tasks for the developing residency program and supporting the consultation-liaison service in the old South Wing building. She started with Area Health Education Center (AHEC) at it’s inception with Dr. Seymour Halleck, the first director of the AHEC program at and a key point person for the AHEC Mental Health Initiative in North Carolina. Her role evolved over time; while working for the consult service, she had many opportunities to leave psychiatry but she liked the faculty and staff with whom she worked with too much. In 2000, the neurosciences hospital opened where psychiatry held offices on all but the ground floor, including for both research labs and the TEACCH program. “It was lots of fun and there were many opportunities to do and learn new things.” Even then, she had a reputation for her strong work ethic, meticulous detail, and reliability.

When some of the longest-serving members of the faculty retired, Myra Daniel was working with Jack Haggerty, MD, in Community Psychiatry and AHEC. “All residents were at AHEC sites in PGY2 and 4, not at the hospital, but out in the community as far as Asheville, Charlotte and Wilmington. Jack and I flew around in the AHEC planes visiting sites and attending regional and state meetings.” She explains, “It was extremely interesting to meet all the people across the state and actually see where the residents all working, touring the different psychiatry units, and meet their supervisors. Many residents wound up returning to their sites to work after graduation. This was my most interesting long-term role. No one has the opportunity to do that now – it’s too expensive, but it was a lot of fun!”

“Everyone I’ve ever worked with has been wonderful, that’s why I stayed. I really enjoy it. Everyone ought to be so lucky and love their jobs as much.”

Myra with her 3/4 Arabian Vido Barbarino and my Purebred Magikhat AF at Region 15 Championships in 2017

When asked what the biggest difference she has seen is over the past half-century Myra explains, “How big and how diverse the department is now! Once I knew every single faculty member, there were about 50-100 that I had a lot of contact with. Now it’s huge, I can’t keep up with all the new people, unless they were residents here.” She goes on to share, “The diversity of specialty programs and computerization of everything is wonderful; it all used to be on paper.”

Myra lives in Roxboro with her husband Charles, a retired member of US Geological Survey and Geology department. Together, they are equestrians, having bred and raised Arabian horses for many years. Myra is an award-winning horsewoman and still rides her three Arabian horses to this day. She attributes her life of horses to her grandfather who raised ponies for carousel rides and farms. “We always would catch and ride ponies (the 14 grandchildren). We would play Old West cops and robbers on horseback. I got my own first pony in third grade. I eventually passed the pony to my younger sister and got a horse in 6th grade. It became a life-long passion.”

Looking back on her extensive career with Psychiatry Myra describes her time by sharing, “I’ve enjoyed all of it and I don’t regret staying in the same department. Nothing has ever seemed as interesting, the people aren’t as interesting as those are in psychiatry.”

Today, she continues doing some of the same roles she started with. She works with regional AHEC directors to set up programs, helps with fourth year medical student orientation and she enjoys placing residents at different sites for them to fulfill their community hours needed to graduate, sharing “I get to work with all PGY4’s at some point in time, it’s fun to get in contact with everyone.” Myra continues to work supporting our residency program with Drs. Karon Dawkins, Winston Li, and Jimmy Chen – and the quality of her contribution remains timeless. We celebrate Myra’s extensive contributions and dedication to the Department of Psychiatry and we are thrilled to continue to have her as a department member. Thank you for the decades of great work, Myra Daniel!

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