黑料网

Developing a Scalable Digital Program to Treat Youth Anxiety

Award Date: 03/2025
PI: Danielle Roubinov, PhD
Anxiety disorders are prevalent and impairing mental health conditions during childhood. Although anxiety is effectively treated with exposure therapy, stark shortfalls in the availability of trained mental health providers mean that many youth cannot access care. The current project will adapt a face-to-face treatment program for youth anxiety into a scalable, self-paced digital program in which youth can engage regardless of geographic area.

Peripubertal social motivation as a novel risk factor linking childhood threat exposure and suicidal ideation and behavior in preteen girls.

Award Date: 09/2024
PI: Andrea Pelletier-Baldelli, PhD; Adam Bryant Miller, PhD
Suicide is the second leading cause of death in youth aged 10-12, and recent years indicate a particular rise in suicidal thoughts and behaviors in girls. This research study is among the first to examine risk trajectories and mechanisms that increase risk for preteen suicide in girls. Findings will help link distal risk factors (i.e., childhood abuse) and potential proximal risk factors (i.e., maladaptive social motivation and advanced pubertal timing) to inform a better understanding of the developmental pathways to suicide risk.

Stress Trajectories and Anhedonia in Adolescence Research Study (STAARS)

Award Date: 07/2024
PI: Danielle Roubinov, PhD; Ayse Belger, PhD
Anhedonia (the loss of interest or pleasure in things that were previously enjoyable) is a potent risk factor for depression and other mental health problems that emerge in adolescence. This study will collect biological, psychological, social, and neuroimaging data repeatedly across a two-year period from adolescents who experience higher or lower levels of anhedonia and their caregivers to better understand how to prevent and intervene in the onset and trajectory of anhedonia.

Identifying Novel Biological Profiles of Early Risk and Intervention for Mood Disorders in Adolescents: Mapping Stress-Responsive Changes in Electrocortical Indices in Adolescent Anhedonia

Award Date: 04/2024
PI:Cope Feurer, PhD; Danielle Roubinov, PhD; Ayse Belger, PhD
Anhedonia is a core symptom of depression that often emerges in adolescence and predicts future depression onset and severity. Interpersonal stress plays a key role in the development of anhedonia, yet not all youth exposed to stress develop anhedonia. Thus, there is a critical need to identify mechanisms that increase risk for anhedonia when youth are exposed to interpersonal stress. This study will identify novel biological profiles that reflect distinct patterns of neural and physiological responses to stress and will examine which biological profiles predict increased risk for adolescent anhedonia.

Identifying Modifiable Risk Factors Associated with Suicidality in Adolescents Following Acute Psychiatric Hospitalization

Award Date: 04/2024
PI: Gabrielle Hodgins, MD
Youth who experience an acute inpatient hospitalization are at particularly high risk of suicide in the weeks and months following hospital discharge. However, there is limited information about the factors that heighten or reduce risk for suicide during the post-hospitalization period. This study will collect critical data on suicidal thoughts and behaviors, psychiatric symptoms, and perceptions of the hospital experience from youth during and after an inpatient stay at the recently opened 黑料网 Youth Behavioral Health (YBH) hospital. This information will further our understanding of modifiable factors that reduce youth risk for suicide following hospital discharge.

Resilience through Interventions for Successful Early Outcomes (RISE)

Award Date: 01/2024
PI: Danielle Roubinov, PhD
Adversity exposure in childhood is one of the most significant predictors of poor health and development. Early trauma impacts children鈥檚 stress-sensitive biological systems, resulting in 鈥渨ear and tear鈥� on the body, with effects that may persist across the life course. With partners from the 黑料网 Child Medical Evaluation Program (/pediatrics/cmep/) and Center for Child and Family Health (https://www.ccfhnc.org/), this project will deliver an evidence-based intervention to children and their families who have been exposed to adversity. Before and after treatment, we will collect non-invasive measures of children鈥檚 stress functioning to understand how treatments may 鈥渞epair鈥� the biological harms of adversity exposure and explore factors that make some children more likely to respond to treatment.

For more information about this study and to see if you may be eligible, .

Supporting Healthy Individuals through Nurturing Environments (SHINE)

Award Date: 12/2023
PI: Danielle Roubinov, PhD
Children whose parents were exposed to severe trauma 鈥� including sexual violence 鈥� are at elevated risk for posttraumatic stress disorder. Current research on trauma is narrowly siloed into two categories: 1) research on adult trauma exposure and its effects on adult mental health 2) research on child trauma exposure and its effects on child mental health. Scarce research bridges these two literatures to examine how exposure to parental trauma impacts parenting and mental health risk in offspring. The present study will recruit 100 mother-child dyads consisting of an adult woman who received emergency care after sexual assault and her offspring ages 8-14 years. Families will be followed for 6 months and will provide data on parent and child mental health, coping, parenting, and other aspects of the family environment. Results will be used to identify modifiable risk factors for youth mental health problems after caregivers are exposed to traumatic stress and develop prevention and intervention programs.

The Life Experience and Emotion Development Study (LEED)

Award Date: 09/2023
PI: Adam Bryant Miller, PhD; Caroline Oppenheimer, PhD
For some youth, risk factors for suicide may emerge early in life. This research study is among the first to explore how and when self-injurious thoughts and behaviors (STBs) emerge in young children during middle childhood. Findings will help identify potential risk factors and mechanisms that may serve as intervention targets for preventing STBs and reducing distress early in development.

Implementing and Evaluating a New Evidence-Based Intervention for Youth Anxiety and Depression into a Pediatric Primary Care Setting

Award Date: 09/2023
PI: Danielle Roubinov, PhD
Child and adolescent mood and anxiety disorders are common and there is a shortage of trained mental health care providers who can provide care. Brief, research-backed programs that are delivered in primary care settings can increase access to effective services. A brief intervention may be a 鈥渟tand alone鈥� approach to treating symptoms, or may the first step before more intensive care is delivered. First Approach Skills Training (FAST) is a suite of brief interventions that have been adapted from longer evidence-based programs to treat pediatric anxiety and depression. In partnership with two 黑料网 pediatric primary care clinics we are conducting a proof-of-concept study to test the feasibilty and preliminary effects of FAST for anxiety (FAST-A) and depression (FAST-D). Results will be used to refine and expand FAST programs to other settings within and outside of 黑料网.

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Does Social Motivation in Adolescence Differentially Predict the Impact of Childhood Threat Exposure on Developing Suicidal Thoughts and Behaviors?

Award Date: 09/2023
PI: Andrea Pelletier-Baldelli, PhD
Childhood threat exposure (e.g., family/community violence) is a key risk factor for developing suicidal thoughts and behaviors; yet, not all adolescents with childhood threat exposure develop these symptoms. Disruptions to social motivation 鈥� the motivations driving the desire and effort to socially interact 鈥� may play a role in differentiating suicide risk. The current study will identify whether maladaptive social motivation presentations during adolescence moderate the link between childhood threat exposure and suicidal thoughts/behaviors in an effort to improve risk identification and mechanistic targets for interventions.

Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls

Award Date: 09/2022
PI: Cope Feurer, PhD

Risk for major depressive disorder (MDD) dramatically increases during adolescence, particularly for females, and although interpersonal stress generation is an established risk factor, it is essential to clarify the underlying mechanisms to improve early detection and prevention of depression risk. The current study will utilize a multi-wave prospective design to examine neural and real-world affective reactivity to negative social interactions as prospective predictors of interpersonal stress generation and subsequent increases in depression symptoms in female adolescents at elevated risk for depression. Ultimately, the elucidation of brain and behavioral mechanisms underlying interpersonal stress generation and subsequent depression risk in female adolescents may contribute to greater understanding of the etiology of adolescent depression and aid in identifying novel targets for intervention.

For more information about this study and to see if you and your teen may be eligible, .

Autistic Adults and other Stakeholders Engage Together 鈥� Suicide Prevention

Award Date: 08/2022
PI: Shari Jager-Hyman, PhD; Danielle Roubinov, PhD
Suicide is the second leading cause of death among young people. Autistic individuals are at elevated risk for experiencing suicidal ideation and are more likely to die by suicide as compared to the general population. This multi-site cluster radnomized controlled trial compares the effectiveness of two tailored approaches to suicide prevention among autistic youth: SPI-A delivered in a single encounter and SPI-A+, a multi-component intervention.

Learn more information about this project.