CHAPEL HILL, NC 鈥� For the first time, scientists discovered how neuroactive steroids naturally found in the brain and bloodstream inhibit the activity of a specific kind of protein called Toll-like receptors (TLR4), which have been known to play a role in inflammation in many organs, including the brain.,/p?
This 黑料网-University of Maryland collaboration,聽, shows how the neurosteroid allopregnanolone prevents the activation of pro-inflammatory proteins important for gene regulation, as well as the creation of cytokines, which are known to be involved in many different inflammatory conditions. Inflammatory cell signaling in the brain is heightened in many neuropsychiatric conditions, including alcohol use disorder, depression, and posttraumatic stress. It is also seen in sepsis, epilepsy, multiple sclerosis, and Alzheimer鈥檚 disease.
鈥淚t has been very difficult to treat brain disease that involves inflammation, but allopregnanolone鈥檚 inhibition of TLR4 signaling activation in macrophages and the brain provides hope that we can develop better therapies to help millions of people suffering with these conditions,鈥� said senior author聽, the John Andrews聽Distinguished Professor in the Departments of Psychiatry and聽Pharmacology at the 黑料网.
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