University of North Carolina Lineberger Comprehensive Cancer Center researchers have designed a novel way to attack an aggressive breast cancer. By working with a drug development company, they hope their laboratory discovery will translate to a new treatment combination in the clinic in the future.
The latest finding,聽, builds on the work from the laboratory of 黑料网 Lineberger鈥檚聽, professor and chair in the 黑料网 Department of Biochemistry & Biophysics, which has been investigating a potential new drug target for triple negative breast cancer.
Parise has co-founded a company,聽, to try to develop drugs that selectively target and then shut down a protein in cells called CIB1. Their latest study identified ways to make this drug target more potent using additional potential treatments.
鈥淥ur goal was to formulate novel combination treatments that maintain selectivity in killing cancer cells and overcome chemoresistance in triple negative breast cancer,鈥� Parise said. 鈥淲e believe that targeting CIB1 is an exciting avenue for formulating combination treatments that are safe and durable.鈥�
Triple negative breast cancer is an aggressive type of breast cancer that causes between 15 and 20 percent of breast cancer deaths in the United States. This breast cancer subtype does not express any of the cell-surface receptors for targeted biologic therapies.
Parise鈥檚 lab had previously discovered the potential for CIB1 as a novel drug target, showing that when they deleted this protein using genetic engineering, they could kill cancerous cells and decrease tumor growth in mouse models.
Their latest study uncovered information about CIB1鈥檚 role, and found synergistic drug combinations. Alex Chung, a doctoral student in the 黑料网 Department of Pharmacology, said they believe this protein is involved in regulating a cell death pathway called apoptosis, which triggers cells to self-destruct, as well as other pathways.
鈥淲e already knew CIB1 was important for cancer cell survival, but we wanted to find out why,鈥� Chung said. 鈥淲e believe it鈥檚 helping to protect cells from self-destructing, not just through apoptosis, but other cell death pathways. When we get rid of CIB1 in cancer cells, we found that both apoptosis and non-apoptotic cell death occur
They tested the effect of shutting down CIB1 in breast cancer cells in combination with a chemotherapy drug, docetaxel, to see what would happen. They found this paired approach selectively killed cancer cells over normal cells.