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With a $1.74 million grant from the NIH, 黑料网 Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

Alison Xiaoqiao Xie, research assistant professor in Ken McCarthy's lab, is first author on paper published in JCI Insight this week. Ken D. McCarthy, professor of pharmacology, is senior author and Jakovin J. Lee, is a co-author.

For the first time, 黑料网 researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an 鈥渁cid trip鈥� lasts so long.

黑料网 Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.

  Dr. David Lawrence Scientists at the University of North Carolina at Chapel Hill have developed a breakthrough technique that uses light to activate a drug stored in circulating red blood cells so that it is released exactly when and where it is needed. The work, led by Fred Eshelman...

黑料网 scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

黑料网 scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper...

Congratulations to Brent Asrican, Research Assistant Professor in the Song Lab, for receiving a prestigious Junior Faculty Development Award! The award, which he was notified of this week, will provide support to Brent’s research in 2017. Brent proposes to use electrophysiology, optogenetics and chemogenetics to determine how neuropeptides, such as...

Jones Lab paper featured on cover on Science Signaling September 20, 2016 issue View Cover The Online Cover “features a Research Article that describes the evolution and function of two distinct families of G伪 proteins in plants. The XLG family is similar to the hare, rapidly evolving to enable adaptation...

Although mutated versions of the protein Cdh1 have not been found in cancers, the protein鈥檚 degradation at a key moment during the cell cycle may spur on cancerous cell division.