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ºÚÁÏÍø researchers including Leslie Parise, PhD, and graduate student, Alex Chung, have designed a novel way to attack an aggressive breast cancer.

Led by Leslie Morrow, PhD, research shows how new compounds could target specific brain cell receptors to treat a wide variety of conditions, such as alcoholism, Alzheimer’s, depression, and posttraumatic stress.

Pharmacology’s Bryan Roth teamed with UCSF and European researchers to create a platform to screen hundreds of millions of never-before-synthesized compounds and then produce remarkably potent antibacterial and psychiatric drug candidates.

ºÚÁÏÍø researchers led by Mauro Calabrese, PhD, have developed a way to categorize mysterious RNA molecules by their likely function, a big first step toward quickening the discovery of their roles in human health and diseases, such as cancers.

By crystalizing a serotonin receptor bound to several common compounds, ºÚÁÏÍø scientists led by Bryan L. Roth discovered how slightly different drugs can cause severe side effects or none at all. The findings should accelerate the design of safer and more effective medications for a variety of...

ºÚÁÏÍø neuroscientist Juan Song, PhD, and colleagues show how specific brain cells communicate with adult neural stem cells, a discovery that could open new investigations into potential treatments for some neurological disorders and brain injuries.

In a study published in the journal Science, researchers led by ºÚÁÏÍø Lineberger's Qing Zhang, Assistant Professor in the departments of Pathology & Laboratory Medicine and Pharmacology, suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney...

Two genomic-based studies from Heart Healthy Lenoir were published in the last month. Heart Healthy Lenoir was a multidisciplinary research project that aimed to reduce cardiovascular disease in Lenoir County, North Carolina by developing new approaches to care, from prevention to treatment. The lead investigator of the Heart Healthy Lenoir...

Scientists led by Rob Nicholas, PhD, at the ºÚÁÏÍø show how the gonorrhea bacterium resists last-resort antibiotic ceftriaxone while maintaining a robust growth rate.