1.0Bryant Lab/pharm/bryantlabBetsy Clarke/pharm/bryantlab/author/bclarke/Research - Bryant Labrich600338<blockquote class="wp-embedded-content" data-secret="sL829zNpoC"><a href="/pharm/bryantlab/research/">Research</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="/pharm/bryantlab/research/embed/#?secret=sL829zNpoC" width="600" height="338" title="“Research” — Bryant Lab" data-secret="sL829zNpoC" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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The role of KRAS in the increased autophagic activity required for PDAC growth. In a comprehensive mechanistic study (Bryant et al., Nature Medicine 2019), we found that the genetic suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector, ERK MAPK. We speculated that ERK inhibition might enhance PDAC dependence on autophagy … Read more/pharm/bryantlab/wp-content/uploads/sites/1319/2022/07/Research_Blurb-1-300x100.jpg