{"id":27998,"date":"2021-04-13T17:07:22","date_gmt":"2021-04-13T21:07:22","guid":{"rendered":"https:\/\/www.med.unc.edu\/pediatrics\/?page_id=27998"},"modified":"2024-10-11T17:24:08","modified_gmt":"2024-10-11T21:24:08","slug":"cellular-therapy-research","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/cellular-therapy-research\/","title":{"rendered":"Cellular Therapy Research"},"content":{"rendered":"            <section>\n                <ul class=\"divisions-container multi-column\" aria-label=\"people-directory\">\n            <li class=\"row post entry\">\n    <div class=\"directory-gallery-thumbnail\">\n                                                                    \n                            <div class=\"entry-title\">\n                                    <a class=\"post-author\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/barbara-savoldo-md-phd\/\">\n                                        <div class=\"upd-image\">\n                            <img loading=\"lazy\" decoding=\"async\" class=\"upd_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2024\/01\/FIMG_HEMONC_Savoldo-Barbara.png\" alt=\" \" height=\"160\" width=\"120\"\/>\n                            <img decoding=\"async\" class=\"print_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2024\/01\/FIMG_HEMONC_Savoldo-Barbara.png\" alt=\" \" \/>\n                        <\/div>\n                                                    Barbara Savoldo, MD, PhD                                                            <\/a>\n                                <\/div>\n            \t\n            <\/div>\n\n    <div class=\"directory-gallery-content\">\n\n        \n\n        <div class=\"ud-gallery-view__positions\"><p class=\"ud-gallery-view__positions__title\">Champion Mitchell Distinguished Professor<\/p><p class=\"ud-gallery-view__positions__title\">Professor of Pediatrics<\/p>            <\/div>\n                \n                    \n<\/li>                <\/ul>\n            <\/section>\n                            <\/nav>\n\n            \n<p>Dr. Barbara Savoldo\u2019s research is on T-cell therapy in the fight against cancer; T-Cell Therapy re-engineers a type of white blood cell called a T-cell, so that the cell can recognize and kills cancerous\u00a0cells. This re-engineering inserts a gene into the T-cell using the ability of certain viruses to insert their genes into host cells.Dr. Savoldo&#8217;s research is primarily on Hodgkin lymphoma and non-Hodgkin lymphoma, two types of cancer marked by uncontrolled growth of certain white blood cells. She plans to open trials for patients with leukemia. She would like to expand this study to include patients with solid tumors, like neuroblastoma and brain tumors.<\/p>\n<figure id=\"attachment_3868\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><a href=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/savoldolab.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3868 size-medium\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/savoldolab.jpeg\" alt=\"\" width=\"300\" height=\"200\" \/><\/a><figcaption class=\"caption wp-caption-text\">Dr. Savoldo works in her lab.<\/figcaption><\/figure>\n<p>In addition to her interest in the preclinical development of cancer immunotherapy approaches for hematological and solid tumors, Dr. Savoldo provide support in writing protocols, developing standard operating procedures and training T-cell processing staff operating in the facility in order to implement T-cell therapy clinical trials at the University of North Carolina, Chapel Hill. Dr. Savoldo is also the assistant director of the Lineberger Immunotherapy Program.<\/p>\n<h2>Open Clinical Trials<\/h2>\n<table class=\"table table-bordered\" border=\"0\">\n<tbody>\n<tr>\n<th>Diagnosis<\/th>\n<th>Age Range<\/th>\n<th>Study Title<\/th>\n<\/tr>\n<tr>\n<td>ALL, Immune System Diseases, Immunoproliferative Disorders<\/td>\n<td style=\"text-align: center\">\u00a01 Year and Older<\/td>\n<td><span style=\"color: #4b9cd3\"><a class=\"external-link\" title=\"\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03016377\" target=\"_self\" rel=\"noopener noreferrer\"><span style=\"color: #4b9cd3\">Administration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic Leukemia<\/span><\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td>Lymphomas<\/td>\n<td style=\"text-align: center\">3 years and Older<\/td>\n<td><span style=\"color: #4b9cd3\"><a class=\"external-link\" title=\"\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02663297\" target=\"_self\" rel=\"noopener noreferrer\"><span style=\"color: #4b9cd3\">Phase I Study of Administration of T Lymphocytes Expressing the CD30 Chimeric Antigen Receptor (CAR) for Prevention of of Relapse of CD30+ Lymphomas after High Dose Therapy and Autologous Stem Transplantation (ATLAS)<\/span><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><\/h3>\n<a class=\"btn btn-primary btn-lg givebtn  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Savoldo+B.\">List of publications by Dr. Savoldo<\/a>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Barbara Savoldo\u2019s research is on T-cell therapy in the fight against cancer; T-Cell Therapy re-engineers a type of white blood cell called a T-cell, so that the cell can recognize and kills cancerous\u00a0cells. This re-engineering inserts a gene into the T-cell using the ability of certain viruses to insert their genes into host cells.Dr. &hellip; <a href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/barbara-savoldo-md-phd\/\" aria-label=\"Read more about Barbara Savoldo, MD, PhD\">Read more<\/a><\/p>\n","protected":false},"author":3424,"featured_media":0,"parent":27353,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-27998","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cellular Therapy Research | Department of Pediatrics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/cellular-therapy-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cellular Therapy Research | Department of Pediatrics\" \/>\n<meta property=\"og:description\" content=\"Dr. Barbara Savoldo\u2019s research is on T-cell therapy in the fight against cancer; T-Cell Therapy re-engineers a type of white blood cell called a T-cell, so that the cell can recognize and kills cancerous\u00a0cells. This re-engineering inserts a gene into the T-cell using the ability of certain viruses to insert their genes into host cells.Dr. &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/cellular-therapy-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pediatrics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncchildrenshospital\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-11T21:24:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/savoldolab.jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@uncchildrens\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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