Publications
- AAV vector transduction restriction and attenuated toxicity in hESCs via a rationally designed inverted terminal repeat.听Nucleic Acids Res. 24;53(3). PMID: .
- A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex听vivo gene therapy.听Mol Ther.听6;32(11):4006-4020.听PMID: .
- AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease.听Mol Ther Methods Clin Dev 29:227-235.听PMID: .
- Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy.听PLoS One. 17(8):e0270972.听PMID: .
- Bower, J.J., Song, Z., Song, L. Subconjunctival administration of Adeno-associated (AAV) vectors in small animal models.听 (2022) Journal of Visual Experimentation (JOVE),听PMID:听
- Bower, J.J., Song, L., Bastola, P., and Hirsch, M.L. (2021) Harnessing the natural biology of adeno-associated virus to enhance the efficacy of cancer gene therapy. (Invited Review, Viruses Special Issue:听 The Application of Viruses to Biotechnology) Viruses 13(7):1205听 PMID:听
- Song, L., Bower, J.J., Llanga, T., Salmon, J.H., Hirsch, M.L., and Gilger, B.C. (2020) Ocular tolerability and immune response to corneal intrastromal AAV-IDUA gene therapy in New Zealand White rabbits. Molecular Therapy 鈥� Methods and Clinical Development 18:24-32听 PMID:听
- Crabtree, E., Song, L., Llanga, T., Bower, J.J., Cullen, M., Salmon, B., Hirsch, M.L., and Gilger, B.C. (2019) AAV-mediated expression of HLA-G reduces severity of experimental autoimmune uveitis in the Lewis rats.听 Sci Rep 9(1):19864.听PMID:听
- *Bower, J.J., Vance, L.D., Psioda, M., Smith-Roe, S.L., Ibrahim, J.G., Hoadley, K.A., Perou, C.M., and Kaufmann, W.K. (2017) Patterns of Cell Cycle Checkpoint Deregulation Associated with Intrinsic Molecular Subtypes of Human Breast Cancer Cells. NPJ Breast Cancer 听(*Corresponding Author)听听PMID:听
- Dumitru, R., Gama, V., Fagan, B.M., Bower, J.J., Swahari, V., Pevny, L., and Deshmukh, M. (2012) Human embryonic stem cells have constitutively active Bax at the golgi and are primed to undergo rapid apoptosis.听 Mol Cell 46:573-83.听听PMID:听
- Dellon, E.S., Bower, J.J., Keku, T.O., Chen, X., Miller, C.R., Woosley, J.T., Orlando, R.C., and Shaheen, N.J. (2012) Markers of tyrosine kinase activity in eosinophilic esophagitis: A study of the FIP1L1-PDGFR伪 fusion gene, pERK 1/2, and pSTAT5.听 Dis Esoph 25:166-74.听 PMID:听
- Hirsch, M., Fagan, B.M., Dumitru, R., Bower, J.J., Yadav, S., Porteus, M.H., and Samulski, R.J. (2011) Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells. PLoS ONE 6:e27520.听听PMID:听
- Bower, J.J., Karaca, G.F., Zhou, Y.C., Simpson, D.A., Cordeiro-Stone, M., and Kaufmann, W.K. (2010) Topoisomerase II伪 maintains genomic stability through decatenation G2 checkpoint signaling.听 Oncogene 29:4787-4799.听 PMID:听
- Bower, J.J., Zhou, Y., Zhou, T., Simpson, D.A., Arlander, S., Paules, R.S., Cordeiro-Stone, M., and Kaufmann, W.K. (2010) Revised genetic requirements of the decatenation G2 checkpoint:听 the role of ATM. Cell Cycle 9:1617-28.听 PMID:听
- Bower, J.J., Leonard, S.S., Chen, F., and Shi, X. (2006) As(III) transcriptionally activates the gadd45a gene via the formation of H2O2.听 Free Rad Biol Med 41:285-294听PMID:听
- Bower, J.J., Leonard, S.S., and Shi, X. (2005) Conference overview:听 Molecular mechanisms of metal toxicity and carcinogenesis. Mol Cell Biochem 279:3-15听 PMID:听
- Bower, J.J. and Shi, X. (2005) Environmental health research in the post-genomic sequencing era:听 New fields, new challenges, and new opportunities. J Toxicol Environ Health B Crit Rev 8:71-94 (invited review)听 PMID:听
- Leonard, S.S., Bower, J.J., and Shi, X. (2004) Conference overview: Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses.听 Mol Cell Biochem 255:3-10听 PMID:听
- Chen, F., Zhang, Z., Bower, J., Lu, Y., Leonard, S.S., Ding, M., Castranova, V., Piwnica-Worms, H., and Shi, X. (2002) Arsenite-Induced Cdc25C Degradation is through the KEN-box and Ubiquitin-Proteasome Pathway. Proc Natl Acad Sci USA 99:1990-5听听PMID:听
- Chen, F., Bower, J., Leonard, S.S., Ding, M., Lu, Y., Rojanasakul, Y., Kung, H.H., Vallyathan, V., Castranova, V., and Shi, X. (2002) Protective Roles of NF-kappa B for Chromium(VI)-induced Cytotoxicity Is Revealed by Expression of Ikappa B Kinase-beta Mutant. J Biol Chem 277:3342-3349.听听PMID:听
- Chen, F., Bower, J., Demers, L.M., Shi, X. (2001) Upstream Signal Transduction of NF-kB Activation. Atlas Genet Cytogenet Oncol Haematol听
- Bohlson, S. S., Strasser, J.A., Bower, J.J., and Schorey, J.S. (2001) Role of Complement in Mycobacterium avium Pathogenesis: In Vivo and In Vitro Analyses of the Host Response to Infection in the Absence of Complement Component C3. Infect Immun 69:7729-7735.听PMID:听