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EMAIL: philip_spanheimer@med.unc.edu

PERSONAL WEBSITE: /surgery/surgonc/directory/philip-m-spanheimer-md/

PUBLICATIONS:

I am a surgical oncologist specializing in breast cancer and sarcoma. I try to bring a patient centered focus to the laboratory to understand disease processes and develop better treatments. Our lab has several ongoing projects and collaborations which are focused around the question of how tumors, or subpopulations within tumors, adapt to therapeutics and become resistant. To do this we use laboratory models and are particularly interested in using primary tumor tissue obtained from the operating room and primary tissue derived models (organoids, patient derived xenografts) to increase the translational relevance of our experiments. Specific projects include characterizing reprogramming of tyrosine kinase signaling pathways with emerging resistance to antiestrogen therapy in ER+ breast cancer, using cell cycle structure as a framework k to understand sensitivity to cell cycle inhibition, and using single cell genomics to predict response to chemotherapy and develop rationally informed treatment strategies in triple negative breast cancer.

In addition to laboratory research, my clinical research focuses on surgical management of cancer and patient outcomes. This goal is to try to understand the interaction and impact of patient factors and surgical management on recurrence, survival, and morbidity of treatment. The focus is to identify patient and tumor characteristics that can help individualize treatment. These areas of investigation also generate hypotheses for biologic and mechanistic studies. In addition to advancing knowledge, these projects provide opportunities to introduce trainees to research methods, which allows them to improve reasoning, writing, and presentation skills, as well as provides a more in-depth foundation to critically appraise the literature.