Mammals use three distinct pathways for repairing chromosome breaks. Ramsden lab is interested in the mechanistic details of how each pathway works, but also how and why a given pathway is chosen, and the consequences of choosing the \u201cwrong\u201d pathway. Ramsden lab\u2019s work has relevance to normal organismal development and aging, as well as carcinogenesis and cancer therapy. Notably, repair of chromosome breaks is also central to genome engineering.<\/p>\n
Ramsden lab uses diverse approaches, including biochemical analyses and somatic cell genetics. Ramsden lab also work closely with a wide variety of labs with expertise in protein structure determination, biophysics, cell biology, and model organism genetics.<\/p>\n","protected":false},"featured_media":4441,"template":"","meta":{"_acf_changed":false},"affiliation":[38],"database-category":[295],"expert-year":[287],"class_list":["post-4440","faculty-expert","type-faculty-expert","status-publish","has-post-thumbnail","hentry","affiliation-biochem","database-category-genetics-and-gene-therapy","expert-year-287","odd"],"acf":[],"yoast_head":"\n