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The DNA packaging capacity of the Adeno-Associated Vectors (AAV) is relatively small, currently rendering it deficient for the treatment of diseases requiring large gene transfer (>4.7kb). To overcome this size limitation, we have developed a novel technique (OAGR) and characterized existing approaches that exploit host DNA repair pathways for intracellular...

During normal respiration, thousands of bacteria and other airborne irritants are inhaled every hour. Despite this constant intake of pathogens, the body is able to maintain sterility in the airways below the larynx. The task of accomplishing this feat falls to the protect airway surface liquid layer, a two-phase liquid...

My research interests involve the structure of inhibitory neuronal networks and how these networks change to produce adverse behavioral outcomes. My main interest is how the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) regulates neuronal networks via both synaptic and extrasynaptic forms of inhibition and how alterations in inhibitory networks contribute to...

Dr. Herfarth鈥檚 specializes in the clinical care of patients with inflammatory bowel diseases. His research interests comprise the investigation of novel diagnostic and therapeutic approaches in patients with inflammatory bowel diseases (IBD). His focus is the conceptualization and execution of investigator-initiated clinical studies in IBD, which are funded by the...

ACL reconstruction Return to physical activity

I am a research scientist with an active interest in the field of benign hematology working to better understand processes that drive inappropriate activation of coagulation and thrombosis. My research is translational in nature using epidemeological and clinical observations to inform key mechanistic studies that provide critical insights into human...

Advanced mucosal resection of lesions throughout the digestive tract: endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), full-thickness resection Third space endoscopy: Peroral endoscopic myotomy (POEM), G-POEM, Z-POEM Advanced therapeutic endoscopy: ERCP, EUS

The Good Laboratory is focused on the cellular and molecular mechanisms involved in the pathogenesis of a devastating intestinal disease primarily affecting premature infants called necrotizing enterocolitis (NEC). The long-term goal of the Good Lab is to understand the signaling pathways regulating the uncontrolled immune response in NEC and how...

Dr. Susan Girdler is currently a Professor in the Department of Psychiatry, and also serves as Director for the 黑料网 Psychiatry Stress and Health Research Program. Dr. Girdler鈥檚 long-standing research funding from the National Institute of Mental Health has focused on neuroendocrine and neurosteroid stress reactivity in reproductive mood disorders,...

Dr. Bradley Gaynes a Professor of Psychiatry and Epidemiology, Director of the Division of Global Mental Health, and co-Director of the Department of Psychiatry鈥檚 Physician Scientist Training Program. His research focuses on the development and implementation of evidence-based management strategies to treat mental illness, with an emphasis on large scale...

Dr. Flythe鈥檚 research interests include identifying and understanding modifiable mortality determinants among maintenance dialysis patients and developing innovative treatment strategies to reduce these risks. She is particularly interested in hemodialysis procedural risk factors. The majority of her work focuses on dialysis hemodynamics, fluid management, and blood pressure patterns among maintenance...

Severe acute viral infections are one of the world鈥檚 most common causes of hospitalization and mortality with worse outcomes disproportionately affecting resource constrained countries. In the past 15 years we have witnessed the emergence or re-emergence of several viral pathogens that threaten global public health including SARS, pandemic H1N1 Influenza,...