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The work in our laboratory is focused on understanding the molecular pathogenesis of Kaposi鈥檚 sarcoma-associated herpesvirus (KSHV), an oncogenic human virus. KSHV is associated with several types of cancer in the human population. We study the effect of KSHV viral proteins on cell proliferation, transformation, apoptosis, angiogenesis and cell signal transduction pathways. We also study viral transcription factors, viral replication, and the interactions of KSHV with the human innate immune system. Additionally, we are developing drug therapies that curb viral replication and target tumor cells.
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AFFILIATIONS:
Institute for Global Health & Infectious Disease, Lineberger Cancer Center, Microbiology & Immunology |
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