{"id":9600,"date":"2020-10-29T11:09:45","date_gmt":"2020-10-29T15:09:45","guid":{"rendered":"https:\/\/www.med.unc.edu\/neurology\/?page_id=9600"},"modified":"2025-04-17T15:01:35","modified_gmt":"2025-04-17T19:01:35","slug":"epilepsy-neurogenetics","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/neurology\/divisions\/child-neurology-1\/epilepsy-neurogenetics\/","title":{"rendered":"Epilepsy Neurogenetics Initiative"},"content":{"rendered":"<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-12014 size-full\" src=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2.jpg\" alt=\"Five icons representing Team of Experts, Best Practice Protocols, Health Outcomes, Translational Research, and Outreach Program\" width=\"1560\" height=\"367\" srcset=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2.jpg 1560w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2-300x71.jpg 300w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2-1024x241.jpg 1024w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2-768x181.jpg 768w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2-1536x361.jpg 1536w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2021\/10\/Graphic-v2-600x141.jpg 600w\" sizes=\"auto, (max-width: 1560px) 100vw, 1560px\" \/><\/h3>\n<p>The ºÚÁÏÍø Epilepsy Neurogenetics Initiative (ENGI) mission is to apply our expanding scientific knowledge of epilepsy genetics to patient care as we learn more about specialized treatments and medicines.<\/p>\n<p>To achieve this goal, ºÚÁÏÍø child neurologists, geneticists, and researchers collaborate to build a comprehensive and multidisciplinary program that advances the care of patients with genetic epilepsy. These partnerships serve as the foundation for the clinical and translational research conducted through our Epilepsy Neurogenetics Clinic and the Epilepsy Neurogenetics Translational Research Collaboration.<\/p>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-6 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<a class=\"btn btn-primary btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"#ENGI-services-programs\">Services &amp; Programs<\/a>\n<a class=\"btn btn-primary btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.med.unc.edu\/neurology\/divisions\/child-neurology-1\/epilepsy-neurogenetics\/research\/\">Research<\/a>\n<\/div>\n<div class=\"col-lg-6 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<a class=\"btn btn-primary btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"#ENGI-education\">Education<\/a>\n<a class=\"btn btn-primary btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"#ENGI-outreach\">Outreach &amp; Patient Resources<\/a>\n<\/div>\n<\/div>\n<a class=\"btn btn-success btn-lg btn-block  oscitas-bootstrap-container\" target=\"_self\" href=\"#ENGI-patient-referral-appointments\">Patient Referral &amp; Appointments Information<\/a>\n<p>&nbsp;<\/p>\n<h2 id=\"ENGI-services-programs\"><h2 class=\"section-som\"><span>Services &amp; Programs<\/span><\/h2><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6924 alignright\" src=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2019\/05\/9B7A9719-300x208.jpg\" alt=\"Child Neurology - Dr. Fan\" width=\"300\" height=\"208\" srcset=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2019\/05\/9B7A9719-300x208.jpg 300w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2019\/05\/9B7A9719-768x532.jpg 768w, https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2019\/05\/9B7A9719-1024x710.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>The ENGI clinic is committed to providing specialized care to our patients with genetic epilepsy. We prepare individualized treatment plans for each of our patients with the guidance of our multidisciplinary team of experts in child neurology, epilepsy and genetics who discuss each case during their weekly resolution meetings.<\/p>\n<p>The clinic also offers the services of a genetic counselor, a social worker, and referral coordinators to provide additional patient support.<\/p>\n<p>In addition, ºÚÁÏÍø Children\u2019s Hospital and the ENGI provide access to pediatric neuropsychology, neuropsychiatry, pediatric physical medicine and rehabilitation and pediatric therapies (including physical, occupational and speech therapy).<\/p>\n<div role=\"tablist\" class=\"panel-group yourcustomclass oscitas-bootstrap-container\" id=\"unc-accordion-0\">\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-0\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h3 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-0\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-0\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-0\">\n                Who do we treat?            <\/button>\n\n        <\/h3>\n\n    <\/div>\n\n    <div id=\"details-0-0\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">\n<p>We offer patient and family-centered care for:<\/p>\n<ul>\n<li>Children with known or suspected genetic epilepsy syndromes<\/li>\n<li>Children with epilepsy and unclear or non-diagnostic genetic testing results (including variants of unknown significance)<\/li>\n<li>Children with epilepsy with a prior genetic diagnosis that requires additional evaluation<\/li>\n<\/ul>\n<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-1\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h3 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-1\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-1\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-1\">\n                What types of treatments do we offer?            <\/button>\n\n        <\/h3>\n\n    <\/div>\n\n    <div id=\"details-0-1\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">The ENGI clinic offers a wide array of therapeutic options including anti-seizure medicines, individualized diets (managed by a specialized pediatric dietician), neurostimulation device therapies, and surgical management.<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-2\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h3 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-2\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-2\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-2\">\n                How is a diagnosis made?            <\/button>\n\n        <\/h3>\n\n    <\/div>\n\n    <div id=\"details-0-2\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">\n<p>We perform a comprehensive evaluation for each patient and offer a full spectrum of state-of-the-art diagnostic tools to help understand the cause of each child\u2019s seizures and improve care.<\/p>\n<p>These tools include:<\/p>\n<ul>\n<li>Extensive medical history review<\/li>\n<li>Detailed family history review<\/li>\n<li>Comprehensive neurological exam<\/li>\n<li>EEG (interpreted by pediatric epileptologists)\n<ul>\n<li>Routine and ambulatory EEG<\/li>\n<li>Continuous video monitoring in the state-of the-art epilepsy monitoring unit in ºÚÁÏÍø Children\u2019s Hospital\u2019s Level 4 Epilepsy Center, recognized by the National Association of Epilepsy Centers (NAEC)<\/li>\n<\/ul>\n<\/li>\n<li>Brain imaging reviewed by neuroradiologists\n<ul>\n<li>MRI (1.5T, 3T and research 7T MRI)<\/li>\n<li>SPECT<\/li>\n<li>PET CT and PET MRI<\/li>\n<li>fMRI<\/li>\n<\/ul>\n<\/li>\n<li>Genetic testing (reviewed by our multidisciplinary team including neurologists, epileptologists, geneticists and genetic counselors)<\/li>\n<li>Metabolic testing<\/li>\n<\/ul>\n<\/div>\n\n    <\/div>\n        \n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2 id=\"ENGI-education\"><h2 class=\"section-som\"><span>Education<\/span><\/h2><\/h2>\n<p>As a part of the ºÚÁÏÍø Children\u2019s Hospital and the ºÚÁÏÍø&#8217;s academic medical center, we are committed to training the next generation of doctors to provide care for children with known or suspected genetic epilepsies. ENGI offers top-tier educational opportunities and mentoring to medical students, residents and fellows.<\/p>\n<ul>\n<li><a href=\"https:\/\/www.med.unc.edu\/neurology\/education-and-training\/residency-programs\/adult-neurology-residency-program\/\">Adult Neurology Residency Program<\/a><\/li>\n<li><a href=\"https:\/\/www.med.unc.edu\/neurology\/education-and-training\/residency-programs\/child-neurology-residency-program\/\">Child Neurology Residency Program<\/a><\/li>\n<li><a href=\"https:\/\/www.med.unc.edu\/neurology\/education-and-training\/fellowship-opportunities\/epilepsy\/\">Epilepsy Fellowship<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 id=\"ENGI-outreach\"><h2 class=\"section-som\"><span>Outreach &amp; Patient Resources<\/span><\/h2><\/h2>\n<p>ENGI&#8217;s goal is to serve as a local and state resource for patients with epilepsy. We strive to serve children with epilepsy and provide access to evaluations and specialized care by subspecialty experts and multidisciplinary consultations.<\/p>\n<p>Our outreach program aims to:<\/p>\n<ul>\n<li>Create a statewide referral base of neurologists and pediatricians;<\/li>\n<li>Maintain an online presence to expand the visibility and reach to families and physicians;<\/li>\n<li>Establish healthcare collaborations across North Carolina.<\/li>\n<li>Increase access to medically underserved individuals.<\/li>\n<\/ul>\n<h2>Patient Resources<\/h2>\n<p>Patients and family members can use the following links to access more help and care:<\/p>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.med.unc.edu\/neurology\/divisions\/epilepsy-1\/patients\/\">ºÚÁÏÍø Neurology - Epilepsy Division<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/charliefoundation.org\/\">The Charlie Foundation for Ketogenic Therapies<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.cureepilepsy.org\/\">Citizens United for Research in Epilepsy<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/dravetfoundation.org\/\">Dravet Syndrome Foundation<\/a>\n<\/div>\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.epilepsy.com\/\">Epilepsy Foundation<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.scn2a.org\/\">FamilieSCN2A Foundation<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/jacksarmy.org\/\">Jack's Army<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.wishesforelliott.com\/\">Wishes for Elliott<\/a>\n<a class=\"btn btn-primary btn-lg btn-block btn-dark  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.facebook.com\/ºÚÁÏÍøNeurology\/\">ºÚÁÏÍø Neurology Facebook<\/a>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2 id=\"ENGI-patient-referral-appointments\"><h2 class=\"section-som\"><span>Referral &amp; Appointments<\/span><\/h2><\/h2>\n<p>To make an appointment, please have your <a href=\"https:\/\/www.med.unc.edu\/neurology\/patient-care\/referring-provider-resources\/#child-neurology-referral-information-1\">primary care provider send us a referral.<\/a><\/p>\n<p><em><strong>Primary Care Providers should specify Neurogenetics Clinic as the reason for the referral.\u00a0<\/strong><\/em><\/p>\n<ul>\n<li>Providers who have access to\u00a0<a class=\"external-link\" title=\"ºÚÁÏÍø CareLink\" href=\"https:\/\/unccarelink.org\/EpicCareLink\/common\/epic_login.asp\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"external-link\">ºÚÁÏÍø CareLink<\/span><\/a>\u00a0can submit a referral online. If you would like to enroll, click on the link and select \u201cRequest an Account.\u201d You may wish to\u00a0<a class=\"external-link\" title=\"\" href=\"http:\/\/unclineberger.org\/referring\/CareLinkinfo.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">download an overview<\/a>\u00a0of the referral portal or view a\u00a0<a class=\"external-link\" title=\"\" href=\"http:\/\/unclineberger.org\/referring\/ºÚÁÏÍøonlineenrollmentinstructions.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">step-by-step guide<\/a><span class=\"external-link\">\u00a0on how to sign up<\/span>.<\/li>\n<li>If you don\u2019t have a ºÚÁÏÍø CareLink account, please fax a\u00a0<a class=\"internal-link\" title=\"\" href=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2024\/01\/2024ChildNeurologyReferralForm.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">completed referral form<\/a><strong>,\u00a0<\/strong>including a specific referral question and records to (984) 974-KIDS<strong>.\u00a0<\/strong>Please call (984) 974-PEDS if you have any questions.<\/li>\n<\/ul>\n<p>For more information on the referral process, please visit the Referring Provider Resources page.<\/p>\n<a class=\"btn btn-default btn-lg  oscitas-bootstrap-container\" target=\"_self\" href=\"https:\/\/www.med.unc.edu\/neurology\/patient-care\/referring-provider-resources\/\">Referring Provider Resources<\/a>\n<h2 id=\"tic-disorders-clinic-location\"><h2 class=\"section-som\"><span>Clinic Location<\/span><\/h2><\/h2>\n<p><a href=\"https:\/\/www.uncchildrens.org\/uncmc\/unc-childrens\/locations\/profile\/?id=29&amp;searchId=5b5425b9-257c-ef11-a86c-000d3a611ea2&amp;sort=13&amp;page=1&amp;pageSize=10\"><som-cell cell-info=\"{&quot;ID&quot;:19256,&quot;post_author&quot;:&quot;68462&quot;,&quot;post_date&quot;:&quot;2024-09-26 12:27:11&quot;,&quot;post_date_gmt&quot;:&quot;2024-09-26 16:27:11&quot;,&quot;post_content&quot;:&quot;&quot;,&quot;post_title&quot;:&quot;N.C. Children&#8217;s Hospital&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;n-c-childrens-hospital&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2024-09-26 12:29:54&quot;,&quot;post_modified_gmt&quot;:&quot;2024-09-26 16:29:54&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\\\/\\\/www.med.unc.edu\\\/neurology\\\/cell\\\/n-c-childrens-hospital\\\/&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;somcell&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;}\" cell-meta=\"{&quot;_wpv_contains_gutenberg_views&quot;:[&quot;&quot;],&quot;_upd_sortorder&quot;:[&quot;1&quot;],&quot;layout&quot;:[&quot;SingleCellBlocks&quot;],&quot;cellInformation&quot;:[&quot;{\\&quot;singleCellBlocks\\&quot;:{\\&quot;imagePercent\\&quot;:50,\\&quot;imageMinHeight\\&quot;:350,\\&quot;mediaType\\&quot;:\\&quot;image\\&quot;,\\&quot;textAlignment\\&quot;:\\&quot;left\\&quot;,\\&quot;titleAccent\\&quot;:1,\\&quot;cellHeader\\&quot;:\\&quot;N.C. Children&#039;s Hospital\\&quot;,\\&quot;cellText\\&quot;:\\&quot;101 Manning Dr.,\\\\nChapel Hill, NC 27514,\\\\nPhone: (984)974-1000\\&quot;,\\&quot;blockImage\\&quot;:\\&quot;https:\\\/\\\/www.med.unc.edu\\\/neurology\\\/wp-content\\\/uploads\\\/sites\\\/716\\\/2017\\\/06\\\/NC-Childrens-Hospital-Night-6-scaled.jpg\\&quot;,\\&quot;backgroundImageAlignmentX\\&quot;:\\&quot;center\\&quot;,\\&quot;backgroundImageAlignmentY\\&quot;:\\&quot;top\\&quot;,\\&quot;stickerText\\&quot;:\\&quot;ºÚÁÏÍø Hospital\\&quot;,\\&quot;addButton\\&quot;:\\&quot;true\\&quot;,\\&quot;buttonText\\&quot;:\\&quot;Get Driving Directions\\&quot;,\\&quot;buttonLink\\&quot;:\\&quot;https:\\\/\\\/www.google.com\\\/maps\\\/dir\\\/?api=1&amp;destination=N.C.+Children%27s+Hospital%2c+101+Manning+Drive+Chapel+Hill%2c+NC+27514\\&quot;,\\&quot;backgroundColor\\&quot;:\\&quot;white\\&quot;},\\&quot;repeatableBoxes\\&quot;:[],\\&quot;blockType\\&quot;:\\&quot;imageBlocks\\&quot;,\\&quot;blockStyle\\&quot;:\\&quot;halfImage\\&quot;}&quot;],&quot;apiCallInformation&quot;:[&quot;{}&quot;]}\"><\/som-cell><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ºÚÁÏÍø Epilepsy Neurogenetics Initiative (ENGI) mission is to apply our expanding scientific knowledge of epilepsy genetics to patient care as we learn more about specialized treatments and medicines. To achieve this goal, ºÚÁÏÍø child neurologists, geneticists, and researchers collaborate to build a comprehensive and multidisciplinary program that advances the care of patients with genetic &hellip; <a href=\"https:\/\/www.med.unc.edu\/neurology\/divisions\/child-neurology-1\/epilepsy-neurogenetics\/\" aria-label=\"Read more about Epilepsy Neurogenetics Initiative\">Read more<\/a><\/p>\n","protected":false},"author":58435,"featured_media":0,"parent":2284,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-9600","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Epilepsy Neurogenetics Initiative | Department of Neurology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neurology\/divisions\/child-neurology-1\/epilepsy-neurogenetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Epilepsy Neurogenetics Initiative | Department of Neurology\" \/>\n<meta property=\"og:description\" content=\"The ºÚÁÏÍø Epilepsy Neurogenetics Initiative (ENGI) mission is to apply our expanding scientific knowledge of epilepsy genetics to patient care as we learn more about specialized treatments and medicines. 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