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[(in)-261.5(th)20.7(e)-273(D)0(e)18.8(t)0(r)20.7(o)0(i)20.7(t)-271.9(ar)19.7(ea)-263.7(an)19.7(d)-271.8(a)-267.2(co)19.7(ll)14.8(ab)19.7(or)20.9(at)19.6(in)20.7(g)-271.8(i)0(n)20.7(s)0(t)20.9(i)0(t)20.6(u)0(t)14.9(i)0(o)20.7(n)0(.)]TJ /F9 1 Tf 8.9663 0 0 8.9663 313.0582 387.3259 Tm [(Fibroid)-337.4(assessment)]TJ /F5 1 Tf 9.843 0 0 9.843 323.0361 370.8849 Tm [(Tr)19.7(an)19.7(sv)15.3(ag)19.7(in)20.7(al)-354.8(ul)20.7(tr)20.7(as)19.9(ou)20.8(nd)-353.5(is)-353.5(th)20.7(e)-365.1(s)0(t)20.9(a)0(n)19.7(d)0(a)19.7(r)0(d)-353.5(p)0(r)20.9(o)0(c)19.7(e)0(d)19.7(u)0(r)20.9(e)-365.1(fo)20.9(r)-363.9(t)0(h)20.7(e)]TJ -1.0137 -1.1174 TD [(de)13.9(te)19.5(ct)19.6(io)20.7(n)-507.9(a)0(n)19.7(d)-507.9(di)20.7(ag)13.9(no)20.8(si)20.9(s)-507.8(o)0(f)-497.5()0(b)15.2(r)0(o)20.9(i)0(d)20.7(s)0(.)]TJ 7.3823 0 0 6.5614 458.929 364.3086 Tm -.0162 Tc (25)Tj 9.843 0 0 9.843 471.2314 359.8865 Tm 0 Tc [(It)-497.6(is)-497.5(as)-504.3(ac)18.5(cu)19.7(ra)19.7(te)-498.8(as)]TJ -16.0696 -1.1116 TD 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9.843 0 0 9.843 323.0361 242.929 Tm [(The)-362.8(primary)-367.3(outcome)-368.5(of)-359.3(this)-367.3(study)-362.5(was)-362.2(broid)-363.6(presence)]TJ -1.0137 -1.1116 TD [(\(yes/no\))-487.9(at)-481.5(the)-476.9(transvagina)-9.9(l)-479.3(ultrasound)-484.5(examination)-483.8(com-)]TJ T* [(pleted)-423.9(at)-418.2(enrollment.)-421.5(Questionable)-421(broids)-422.2(were)-422.3(those)-415.5(for)]TJ 0 -1.1174 TD [(which)-220.8(at)-222.4(least)-215.2(1)-220(diameter)-221.1(could)-219.9(not)-216.5(be)-216.5(measured.)-224.1(Participants)]TJ 0 -1.1116 TD [(who)-263.4(had)-257.9(at)-262.7(least)-261.3(one)-257.9(broid)-260(or)-261.4(questionable)-264.6(broid)]TJ /F8 1 Tf 20.9308 0 TD ()Tj /F5 1 Tf .72 0 TD [(0.5)-166.9(cm)]TJ -21.6507 -1.1116 TD [(at)-326(enrollment)-320.2(ultrasound)-323.2(\(22%;)]TJ /F10 1 Tf 13.04 0 TD (n)Tj /F8 1 Tf .6681 0 TD (=)Tj /F5 1 Tf .72 0 TD [(377\))-321.2(were)-324.4(considered)-319.7(to)]TJ -14.4281 -1.1116 TD [(have)-329.3(broids,)-321.9(and)-327(all)-327.3(women)-325.6(who)-321(did)-326(not)-326(have)-323.5(a)-324.8(broid)-323.3(or)]TJ 0 -1.1174 TD [(questi)-7.8(onable)-360.4(broid)]TJ /F8 1 Tf 8.628 0 TD ()Tj /F5 1 Tf .72 0 TD [(0.5)-166.9(cm)-361.7(in)-359.4(diameter)-365.1(at)-360.6(enrollment)-360.5(ul-)]TJ -9.348 -1.1116 TD [(trasound)-430.3(\()]TJ /F10 1 Tf 4.2103 0 TD (n)Tj /F8 1 Tf .6681 0 TD (=)Tj /F5 1 Tf .72 0 TD [(1,319\))-423.6(were)-433.8(considered)-429.1(to)-428.5(not)-423.9(have)-432.9(broids.)]TJ -5.5984 -1.1116 TD [(The)-460.7(secondary)-462.4(outcomes)-461.6(were)-456.8(size)-461.7(of)-457.2(the)-453.8(largest)-465.1(broid,)]TJ 0 -1.1174 TD [(number)-279.7(of)-272.9(broids,)-275.8(and)-275.2(total)-272(broid)-277.2(volume.)-277.5(The)-276.4(size)-271.6(of)-278.6(the)]TJ 0 -1.1116 TD [(larges)-8.8(t)-369.9(broid)-375.2(was)-373.8(determined)-378.8(by)-370.8(averaging)-382.1(the)-373.2(maximum)]TJ T* [(diameter)-353.6(\(L,)-346.6(A,)-351(or)-347.7(T\))-348.9(of)-347.7(each)-347.7(of)-347.7(the)-350.2(triplicate)-354.9(broid)-346.4(mea-)]TJ 0 -1.1174 TD [(surements.)-293.1(Fibroid)-290(volume)-285.6(\(cm)]TJ 7.3823 0 0 6.5614 438.066 104.8819 Tm (3)Tj 9.843 0 0 9.843 441.751 100.4598 Tm [(\))-283.3(was)-293.1(measured)-289.8(by)-284.4(comput-)]TJ -13.0745 -1.1116 TD [(ing)-187.7(the)-183.1(volumes)-188.6(of)-180.7(each)-186.4(of)-186.5(the)-183.1(triplicate)-187.9(broid)-185.1(measurements)]TJ T* [(using)-414.4(the)-413.5(ellipsoid)-420.3(formula)-413.4(\(L)]TJ /F8 1 Tf 12.7981 0 TD ()Tj /F5 1 Tf .72 0 TD (A)Tj /F8 1 Tf .887 0 TD ()Tj /F5 1 Tf .72 0 TD (T)Tj /F8 1 Tf .7833 0 TD ()Tj /F5 1 Tf .7142 0 TD [(0.5233\),)-416.6(and)-413.4(aver-)]TJ -16.6225 -1.1174 TD [(aging)-329.3(across)-331.1(the)-321.4(three)-330.5(volumes.)-324.5(Total)-330.7(broid)-323.3(volume)-331.7(\(cm)]TJ 7.3823 0 0 6.5614 545.2156 72 Tm (3)Tj 9.843 0 0 9.843 548.9006 67.5779 Tm (\))Tj -23.9604 -1.1116 TD [(was)-212.5(calculated)-218.8(by)-209.5(adding)-215.3(the)-206.2(average)-219.7(volumes)-211.6(from)-207.2(each)-215.2(of)-209.5(a)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (490)Tj 47.327 0 TD [(MOORE)-330.9(ET)-338.7(AL.)]TJ ET endstream endobj 51 0 obj <>stream /GS1 gs BT /F5 1 Tf 9.843 0 0 9.843 59.7543 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(womans)-200.8(broids.)-195.2(Total)-198.2(broid)-196.6(volume)-193.4(was)-201(not)-193.5(computed)-196.8(for)]TJ 0 -1.1174 TD [(women)-463.8(with)-454.8(only)-459.5(questionable)-460.4(broids)-456.7(\(n)]TJ /F8 1 Tf 17.9242 0 TD (=)Tj /F5 1 Tf .7142 0 TD [(6\))-457.2(because)-461.4(at)]TJ -18.6384 -1.1116 TD [(least)-284.4(1)-283.3(diameter)-284.5(was)-281.6(not)-279.9(measured.)]TJ /F9 1 Tf 8.9663 0 0 8.9663 59.7543 679.5211 Tm [(Reproductive)-334.5(tract)-335.6(infection)-334.4(assessment)]TJ /F5 1 Tf 9.843 0 0 9.843 69.7323 663.0801 Tm [(At)-602.2(enrollment,)-600.1(SELF)-599.7(participants)-604.5(responded)-599.5(to)-601.3(ques-)]TJ -1.0137 -1.1116 TD [(tions)-305.1(regarding)-300.3(their)-300.6(history)-301.5(of)-301.7(RTIs)-300.2(via)-298.3(a)-301.8(self-administered)]TJ 0 -1.1174 TD [(computer-assisted)-341.1(web)-327.9(interviewin)-10(g)-329.4(\(CAWI\))-333.2(questionnaire.)]TJ 0 -1.1116 TD .0199 Tc [(E)-5.4(ach)-430.5(question)-430.5(o)1.5(n)-436.2(t)1.4(he)-437.4(CAWI)-436.2(require)-5.4(d)-430.5(an)-436.2(answer)-436.2(before)]TJ T* 0 Tc [(the)-281.1(next)-276.4(question)-275(was)-281.6(presented.)-275.9(If)-278.6(no)-278.7(answer)-280.3(was)-275.8(recorded,)]TJ 0 -1.1174 TD [(the)-448.1(same)-445.5(question)-442(was)-442.9(presented)-445.3(again,)-443.4(but)-441.2(an)-446.9(additional)]TJ 0 -1.1116 TD [(response)-275.7(category)-277.3(was)-281.6(offered:)-276.1()50.8(prefer)-274.9(not)-279.9(to)-278.8(answer.)55()]TJ 1.0137 -1.1116 TD [(The)-195.7(questions)-195.3(of)-198(interest)-195.6(used)-195.4(for)-193.3(this)-194.5(study)-195.5(were:)-198.9(\(1\))-193.3(Has)-195.2(a)]TJ -1.0137 -1.1116 TD 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[(who)-280.6(did)-274.1(not)-279.9(self-report)-279.3(any)-280.9(RTI)-276.2(diagnosis.)-279.3(Two)-281.8(participants)]TJ 0 -1.1116 TD [(were)-445.3(not)-435.4(included)-443.4(because)-444.1(they)-437.7(responded)-444()50.8(prefer)-441.9(not)-435.4(to)]TJ T* [(answer)46.9()-381.2(for)-377.6(at)-383.6(least)-382.3(one)-378.8(RTI)-379.9(and)-378.8(reported)-379.8()50.8(no)47.5()-375.4(for)-383.4(other)]TJ 0 -1.1174 TD [(RTIs;)-284.1(thus,)-284.2(we)-280.7(could)-277.5(not)-285.7(determine)-279.8(their)-283.4()50.8(any)-282(RTI)45.3()-277.5(status.)]TJ /F9 1 Tf 8.9663 0 0 8.9663 59.7543 365.3857 Tm [(Statistical)-336.1(analyses)]TJ /F5 1 Tf 9.843 0 0 9.843 69.7323 348.9448 Tm [(Because)-433.7(the)-430.8(majority)-432(of)-428.4(questions)-431.4(were)-433.8(asked)-433.9(via)-430.8(tele-)]TJ -1.0137 -1.1116 TD [(phone)-311.9(or)-307.4(web-based)-307.8(interview)-313(where)-308.2(participant)-10.3(s)-306.2(had)-304(to)-307.6(re-)]TJ T* [(spond)-391.2(to)-382.5(a)-388.2(question)-390.2(before)-389(proceeding,)-392.4(there)-388.1(was)-385.3(minimal)]TJ 0 -1.1174 TD [(missing)-268(data.)-258(Any)-263.4()50.8(prefer)-269.1(not)-256.9(to)-261.5(answer)46.9()-266(response)-264.1(\(0.06%)]TJ 0 -1.1116 TD [(0.12%\))-395.9(was)-391(coded)-393.7(as)-394.8(missing,)-392.4(and)-396.1(complete)-393.9(case)-393.6(analysis)]TJ T* [(was)-489(performed.)-483.3(Variables)-486.6(were)-485.6(categorized)-484.7(based)-485.7(on)-480.3(the)]TJ 0 -1.1174 TD [(distribution)-255.5(of)-249.8(the)-252.3(data)-248.8(and)-252.1(comparability)-255.7(with)-247.4(the)-252.3(literature.)]TJ 0 -1.1116 TD [(Al)14.1(l)-387.1(a)0(n)19.7(a)0(l)19.5(y)0(s)21(e)0(s)-383.3(w)0(e)18.8(r)0(e)-377.7(c)0(o)19.7(m)0(p)19.6(l)0(e)19.6(t)0(e)13.8(d)-387(on)-376.6(wo)20(me)18.4(n)-392.8(w)0(h)20(o)-387(re)19.7(po)20.8(rt)15(ed)-377.7(ev)19.7(er)]TJ T* [(be)19.7(in)15(g)-173.9(s)0(e)19.9(x)0(u)15.1(a)0(l)19.5(l)0(y)-163.6(a)0(c)18.5(t)0(i)14.8(v)0(e)-164.6(a)0(n)19.7(d)-179.6(wh)20(o)-179.6(d)0(i)20.7(d)-179.6(no)20.8(t)-174(s)0(e)14.1(l)0(f)20.7(-)0(r)20.9(e)0(p)19.7(o)0(r)20.9(t)-179.8(a)-180.8(d)0(i)20.7(a)0(g)19.7(n)0(o)20.8(s)0(i)20.9(s)-179.5(of)]TJ 0 -1.1174 TD [(hu)15.1(m)15(a)0(n)-354.7(i)0(m)19.5(m)0(u)19.6(n)0(o)20.8(d)0(e)19.7()0(c)14.1(i)0(e)19.6(n)0(c)19.7(y)-364(vi)20.7(ru)20.9(s)-363.8(\()0(H)20(I)0(V)20(\))-363.9(or)-353.5(us)21(e)-365.1(o)0(f)-353.5(H)0(I)20(V)-364.8(me)18.5(di)20.7(-)]TJ 0 -1.1116 TD [(ca)18.5(ti)14.8(on)20.8(s.)-269.3(St)20.9(an)19.7(da)19.7(rd)-267.1(de)19.7(sc)14.1(ri)20.7(pt)20.7(iv)20.7(e)-278.7(s)0(t)15.1(a)0(t)19.5(i)0(s)20.9(t)0(i)20.6(c)0(s)-268.1(w)0(e)13(r)0(e)-268.3(p)0(e)19.7(r)0(f)20.9(o)0(r)20.9(m)0(e)18.4(d)-277.6(fo)15.1(r)-277.5(a)0(l)19.6(l)]TJ T* [(va)19.7(ri)15(ab)19.7(le)19.6(s)-300.4(o)0(f)-290.2(i)0(n)20.7(t)0(e)19.5(r)0(e)19.7(s)0(t)20.9(.)-302.9(Fo)21(r)-300.6(c)0(a)18.5(t)0(e)19.6(g)0(o)20.8(r)0(i)20.7(c)0(a)18.5(l)-300.7(va)19.7(ri)15(ab)19.7(le)19.6(s,)-286.6(pr)20.9(op)15.1(or)20.9(ti)20.6(on)20.8(s)-300.4(a)0(t)]TJ T* [(ea)18.5(ch)-262.5(le)19.6(ve)13.9(l)-271.9(w)0(e)18.8(r)0(e)-262.5(d)0(e)19.7(s)0(c)19.9(r)0(i)20.7(b)0(e)19.7(d)0(.)-263.7(F)0(o)21(r)-271.8(co)19.7(nt)20.7(in)20.7(uo)20.8(us)-267(va)19.7(ri)20.7(ab)19.7(le)19.6(s,)-263.5(me)18.4(di)20.7(an)19.7(s)]TJ 0 -1.1174 TD [(\(i)15(nt)20.7(er)19.7(qu)20.8(ar)19.7(ti)20.6(le)-452.7(ra)19.7(ng)20.8(es)19.9(\))-461.8(w)0(e)18.8(r)0(e)-452.6(c)0(o)19.7(m)0(p)19.6(u)0(t)20.7(e)0(d)19.7(.)-458.4(Al)19.8(th)20.7(ou)20.8(gh)-451.5(se)19.9(xu)20.8(al)-452.7(be)19.7(-)]TJ 0 -1.1116 TD [(ha)19.7(vi)15(or)-330.5(va)19.7(ri)20.7(ab)13.9(le)19.5(s)-340.7(a)0(r)19.7(e)-347.8(no)20.8(t)-341(c)0(o)19.7(n)0(f)20.9(o)0(u)15.1(n)0(d)20.8(e)0(r)19.7(s)0(,)-332.6(w)0(e)-332.5(d)0(e)19.7(s)0(c)14.1(r)0(i)20.7(b)0(e)19.7(d)-340.9(th)20.7(e)-347.8(r)0(e)19.7(l)0(a)19.6(-)]TJ T* [(ti)14.8(on)20.8(sh)21(ip)-221.2(be)19.7(tw)19.8(ee)18.5(n)-231.5(e)0(a)18.5(c)0(h)-222.2(R)0(T)18.6(I)-231.5(an)19.7(d)-231.5(n)0(u)20.8(m)0(b)19.6(e)0(r)-222.2(o)0(f)-221(s)0(e)19.9(x)0(u)15.1(a)0(l)-216.6(p)0(a)13.9(r)0(t)20.7(n)0(e)19.7(r)0(s)-220.8(a)0(n)19.7(d)]TJ 0 -1.1174 TD [(ag)19.7(e)-290.2(a)0(t)-280()0(r)21(s)0(t)-272.8(i)0(n)15(t)0(e)19.6(r)0(c)19.7(o)0(u)20.8(r)0(s)21.1(e)-290.2(fo)20.9(r)-289(c)0(o)19.7(m)0(p)19.6(a)0(r)19.7(i)0(s)20.9(o)0(n)-278.7(w)0(i)19.8(t)0(h)-273(t)0(h)15(e)-284.5(li)20.6(te)19.6(ra)19.7(tu)15(re)19.7(.)-285.7(A)0(l)19.8(l)]TJ 0 -1.1116 TD [(an)19.7(al)13.8(ys)21(es)-262.4(we)18.8(re)-256.8(co)13.9(nd)20.8(uc)19.7(te)19.5(d)-271.8(w)0(i)19.8(t)0(h)-255.8(S)0(A)14.4(S)-265.9(9.)18.5(3.)]TJ /F9 1 Tf 8.9663 0 0 8.9663 59.7543 138.8409 Tm [(Primary)-339.8(analyses:)-332.9(Association)-334.1(between)-331.9(RTIs)]TJ 0 -1.2203 TD [(and)-335.7(broid)-334.3(presence)]TJ /F5 1 Tf 9.843 0 0 9.843 69.7323 111.4582 Tm [(Lo)19.6(gi)20.7(st)15.1(ic)-251.2(re)14(gr)20.9(es)19.9(si)20.9(on)-255.6(mo)19.6(de)19.7(ls)-255.6(we)18.8(re)-256.8(us)21(ed)-256.8(to)-255.8(co)19.7(mp)19.6(ut)20.7(e)-267.2(O)0(R)18.9(s)-265.8(an)19.7(d)]TJ -1.0137 -1.1174 TD [(95)15.1(%)-399.6(c)0(o)19.7(n)0()15.2(d)0(e)19.7(n)0(c)19.7(e)-405.4(in)20.7(te)19.6(rv)20.9(al)19.5(s)-404.1(\()0(C)19.8(I)0(s)15.3(\))-404.2(to)-394(ev)19.7(al)19.5(ua)19.7(te)-395.1(th)20.7(e)-405.4(a)0(s)19.9(s)0(o)15.3(c)0(i)19.5(a)0(t)19.6(i)0(o)20.7(n)0(s)]TJ 0 -1.1116 TD 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[(th)15(e)-445.8(r)0(e)19.7(l)0(a)19.5(t)0(i)14.8(v)0(e)-435.3(o)0(d)20.8(d)0(s)-439.7(w)0(i)19.8(l)0(l)-440.2(o)0(v)20.8(e)0(r)19.7(e)0(s)14.1(t)0(i)20.6(m)0(a)18.4(t)0(e)-435.5(t)0(h)15(e)-445.8(re)19.7(la)13.8(ti)20.6(ve)-435.3(ri)15(sk)21(,)-446.9(b)0(u)20.8(t)-450.5(it)]TJ 25.5097 67.9184 TD [(pr)20.9(ov)20.8(id)20.7(es)-291.2(a)-301.8(v)0(a)19.7(l)0(i)20.6(d)-300.6(me)18.4(th)20.7(od)-290.2(of)-290.1(te)19.6(st)15.1(in)20.7(g)-300.6(f)0(o)20.9(r)-300.6(st)20.9(at)19.5(is)20.9(ti)14.8(ca)18.5(ll)20.6(y)-300.6(s)0(i)20.9(g)0(n)20.8(i)0()20.9(c)0(a)18.5(n)0(t)]TJ 0 -1.1174 TD [(di)20.7(ff)20.9(er)19.7(en)19.7(ce)18.5(s)-421.4(b)0(e)19.7(t)0(w)14.1(e)0(e)18.5(n)-415.8(th)15(os)21(e)-422.7(w)0(i)19.8(t)0(h)-411.3(a)0(n)19.7(d)-415.8(wi)14.1(th)20.7(ou)20.8(t)-421.7(a)-417(se)14.1(lf)20.8(-r)20.9(ep)19.7(or)20.9(te)19.5(d)]TJ 0 -1.1116 TD 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[(do)20.8(ct)19.5(or)20.9(at)19.5(e\))19.7(;)-427.4(b)0(o)20.8(d)0(y)-416.9(m)0(a)18.4(s)0(s)-416.5(i)0(n)20.7(d)0(e)19.7(x)-421.6(\(B)14.1(MI)20(\))-421.5(\()0(1)15.1(5)0()20.8(2)0(4)20.8(,)-423.9(25)20.8(2)20.8(9,)-419.2(30)20.8(3)20.8(4,)]TJ /F8 1 Tf .0115 -1.1116 TD ()Tj /F5 1 Tf .7084 0 TD [(35)15.1(\))-381.2(i)0(n)-370.9(k)0(g)15.1(/)0(m)]TJ 7.3823 0 0 6.5614 365.9527 630.8786 Tm (2)Tj 9.843 0 0 9.843 369.5243 626.5132 Tm [(;)-381.4(a)0(l)19.5(c)0(o)13.9(h)0(o)20.8(l)-381.4(\(l)20.7(ow)20(,)-383.6(m)0(o)19.6(d)0(e)19.7(r)0(a)14(t)0(e)19.6(,)-383.6(he)19.7(av)19.7(y\))20.9(;)-381.4(a)0(n)19.7(d)-387(us)21(e)-382.4(o)0(f)]TJ -5.9613 -1.1116 TD [(De)18.8(po)20.8(-P)21(ro)20.9(ve)13.9(ra)-210.7(\(e)19.7(ve)19.7(r,)-217.6(ne)19.7(ve)19.7(r\))20.9(.)-228.1(T)0(h)19.6(e)-221.1(al)19.6(co)19.7(ho)15.1(l)-220.1(v)0(a)19.7(r)0(i)15(a)0(b)19.7(l)0(e)-210.8(r)0(e)19.7()0(e)14.1(c)0(t)19.6(e)0(d)-210.7(t)0(h)14.9(e)]TJ 0 -1.1174 TD 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[(Secondary)-331(analyses)]TJ /F5 1 Tf 9.843 0 0 9.843 320.8251 368.9574 Tm [(As)-296.6(a)-301.8(secondary)-301.2(analysis)-304.8(we)-298(examined)-301.6(the)-304.1(association)-303.6(be-)]TJ -1.0137 -1.1116 TD [(tween)-342.9(RTIs)-346.2(and)-344.3(three)-347.7(outcomes:)-347.6(size)-346.5(of)-342(the)-344.4(largest)-349.9(broid,)]TJ T* [(number)-291.2(of)-284.4(broid)-6.5(s,)-286.6(and)-292.4(total)-289.3(broid)-288.8(volume.)-289(Medians)-293.1(roun-)]TJ 0 -1.1174 TD [(ded)-430.7(to)-434.3(the)-436.6(nearest)-431.6(whole)-439.7(number)-435.2(were)-433.8(used)-431.6(to)-434.3(determine)]TJ 0 -1.1116 TD [(category)-421.3(cutpoints)-426(for)-417.9(size)-421.4(of)-422.6(the)-419.3(largest)-424.8(broid)-421.2(and)-419.2(total)]TJ T* [(broid)-202.4(volume)-199.2(\(2cm)-208.3(and)-200.3(2cm)]TJ 7.3823 0 0 6.5614 426.2172 318.5574 Tm (3)Tj 9.843 0 0 9.843 429.9022 314.192 Tm [(,)-205(respectively\).)-206.8(To)-199.2(estim)-8(ate)-201.6(the)]TJ -12.0954 -1.1116 TD [(ORs)-235.4(and)-234.9(95%)-234.8(CIs)-234.5(for)-239.4(the)-235(association)-240.2(of)-232.6()50.8(any)-235.9(RTI)51()-237.2(and)-234.9(each)]TJ 0 -1.1174 TD [(RTI)-420.2(and)-419.2(broids,)-419.8(we)-424.7(used)-420.1(multinomial)-419.6(logistic)-425(regression)]TJ 0 -1.1116 TD [(with)-299.3(the)-304.1(same)-307.3(potential)-306.5(confounders)-302.2(as)-302.7(in)-301.8(the)-304.1(primary)-303.9(anal-)]TJ T* [(ysis.)-226.4(All)-229.1(RTIs)-225.3(were)-226.4(included)-230.3(in)-226.9(the)-229.2(models)-227.8(together)-224.5(\(with)-231.2(the)]TJ 0 -1.1174 TD [(exception)-284.4(of)-278.6(PID,)-283.9(which)-278.4(was)-281.6(modeled)-287.9(separately\).)]TJ 1.0137 -1.1116 TD [(As)-406.1(a)-411.2(secondary)-416.4(analysis)-414.2(to)-405.5(examine)-415.7(the)-407.8(association)-418.8(be-)]TJ -1.0137 -1.1116 TD [(tween)-308.3(RTI)-305(exposure)-304.7(severity)-310.7(and)-304(broid)-306(presence,)-310.4(we)-303.7(eval-)]TJ 0 -1.1174 TD [(uated)-232.6(age-)-225.6(and)-234.8(multivariable-adjusted)-233.5(ORs)-235.4(of)-226.8(the)-229.2(association)]TJ 0 -1.1116 TD [(between)-323.2(the)-321.4(number)-325.8(of)-324.7(times)-319(diagnosed)-329(with)-322.3(each)-324.7(RTI)-322.3(and)]TJ T* [(the)-315.6(presence)-318.5(of)-313.2(broids)-318.5(using)-316.5(two)-315.3(indicator)-317.9(variables)-318.7(\(1)-313.2(vs.)]TJ 0 -1.1174 TD [(none;)-306.3(2)]TJ /F8 1 Tf 3.2024 0 TD (+)Tj /F5 1 Tf 1.0195 0 TD [(vs.)-310.7(none\).)-303.8(Because)-312.7(of)-301.7(limited)-310.1(numbers)-309.4(of)-301.7(women)]TJ -4.2219 -1.1116 TD [(reporting)-184.1(multiple)-190.3(infections,)-184(each)-186.4(separate)-191.9(RTI)-184.1(was)-189.5(modeled)]TJ T* [(without)-343(adjusting)-345.3(for)-337.3(other)-346.6(RTIs.)-343.9(In)-336.2(addition,)-347.9(we)-344.1(looked)-342(at)]TJ T* [(whether)-391.1(self-reporting)-392.2(more)-392.7(than)-391.6(one)-390.4(type)-391.6(of)-388.1(infection)-392.7(in-)]TJ 0 -1.1174 TD [(creased)-369.2(the)-361.7(odds)-361.3(of)-365(broids)-364.6(using)-362.5(three)-365(indicator)-369.7(variables)]TJ 0 -1.1116 TD [(\(1)-278.6(vs.)-281.9(none;)-283.3(2)-277.6(vs.)-281.9(none;)-277.5(3)]TJ /F8 1 Tf 10.4078 0 TD (+)Tj /F5 1 Tf 1.0022 0 TD [(vs.)-276.1(none\).)]TJ /F9 1 Tf 8.9663 0 0 8.9663 310.8472 116.9008 Tm [(Sensitivity)-332.1(analyses)]TJ /F5 1 Tf 9.843 0 0 9.843 320.8251 100.4598 Tm [(Syphilis)-314.1(was)-321.9(reported)-316.5(by)-319(too)-314.5(few)-322.1(women)-319.8(to)-313.4(analyze)-323.5(sep-)]TJ -1.0137 -1.1116 TD [(arately)-345.5(\()]TJ /F10 1 Tf 3.4155 0 TD (n)Tj /F8 1 Tf .6681 0 TD (=)Tj /F5 1 Tf .72 0 TD [(15\),)-340.8(but)-343.3(we)-344.1(repeated)-347.6(the)-350.2(primary)-344.2(analyses)-346.1(after)]TJ -4.8036 -1.1116 TD [(excluding)-294.7(them)-294.9(to)-290.3(make)-295.9(sure)-293.3(they)-293.7(were)-295.6(not)-297.2(inuential.)-293.6(Cer-)]TJ 0 -1.1174 TD [(vical)-192.4(treatment)-187.8(is)-192.2(an)-187.7(indicator)-191.2(of)-192.2(cervical)-192.2(lesions)-193.1(secondary)-191.7(to)]TJ 0 -1.1116 TD [(persistent)-520.2(HPV)-523.3(infection)-519.4(and)-517.1(was)-523.5(found)-518.1(to)-514.9(be)-521.7(inversely)]TJ /F3 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(RTIS)-338.7(AND)-330.9(UTERINE)-342.2(FIBROIDS)]TJ 53.0113 0 TD (491)Tj ET endstream endobj 55 0 obj <>stream hތNAo:Q# L)ȟĠCEpr o@ ؘh|B7_e9yq\&zZ*Eqve\23xxXU~ωYb"T($ *< Ɖ@fW" PAxP 4(=%Ak mHt=B:6FNB%ъ\Q' a"h*JjT/e8L9& aOvvv%j]j=['_ohOpW`& endstream endobj 58 0 obj <>stream /GS1 gs BT /F5 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(associated)-395.7(with)-391.4(broids)-393.4(in)-388.2(our)-389.2(previous)-395.8(study.)]TJ 7.3823 0 0 6.5614 251.8298 729.5242 Tm (24)Tj 9.843 0 0 9.843 263.055 725.1588 Tm [(Thus,)-389(the)]TJ -20.4239 -1.1174 TD [(RTI)-264.7(associations)-269.9(we)-269.2(were)-266.8(investigating)-270.5(might)-266.2(be)-262.5(attenuated.)]TJ 0 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[(with)-247.4(women)-244.9(without)-245.1(one,)-244(tended)-245.2(to)-244.2(be)-245.3(older,)-246.4(more)-248.7(educated,)]TJ T* [(heavier)-253.2(drinkers,)-255.2(parous,)-247.1(to)-250(have)-254.4(ever)-254.4(used)-247.3(Depo-Provera,)-256.9(to)]TJ 0 -1.1174 TD [(have)-225.6(more)-219.9(sex)-223.1(partners)-224.1(before)-222(age)-224.5(20)-221.1(years,)-218.4(and)-223.3(to)-221.2(have)-219.8(been)]TJ 0 -1.1116 TD [(younger)-389(at)-389.4(rst)-390(sex)-390.2(\(Table)-390.4(1\).)-385.7(The)-391.6(prevalences)-392.2(of)-388.1(specic)]TJ T* [(self-reported)-444(RTI)-443.2(diagnoses)-444(were:)-440.8(10%)-442.1(for)-441(PID,)-439.4(38%)-442.1(for)]TJ T* [(chlamydia)-193.4(and)-188.8(BV,)-186.1(32%)-188.7(for)-187.5(trichomonas,)-191.9(20%)-188.7(for)-187.5(gonorrhea,)]TJ 0 -1.1174 TD [(9%)-435.2(for)-429.5(genital)-436.6(herpes,)-432.6(and)-430.7(7%)-435.2(for)-429.5(genital)-436.6(warts)-433.7(\(Supple-)]TJ 0 -1.1116 TD [(mentary)-282.1(Table)-285.6(S2\).)-283(The)-282.1(median)-281(time)-283.5(since)-284.2(rst)-286.4(diagnosis)-281.7(of)]TJ T* [(any)-292.4(RTI)-293.5(was)-298.9(9)-289.1(years)-295.6(\(interquartile)-301.7(range:)-291.3(513)-292.4(years\))-296.7(\(Sup-)]TJ 0 -1.1174 TD [(plementary)-286.7(Table)-279.9(S3\).)]TJ 1.0137 -1.1116 TD [(Twenty-two)-453.1(percent)-449(\(22%\))-450(of)-451.4(women)-452.3(had)-448(broids)-451(dis-)]TJ -1.0137 -1.1116 TD [(covered)-310.7(at)-308.8(ultrasound)-311.7(screening)-312.8(\(Table)-309.7(2\).)-310.9(Of)-308.3(those)-306.1(with)-310.8(-)]TJ 0 -1.1174 TD [(broids,)-372.8(the)-373.2(size)-375.3(of)-376.5(the)-373.2(largest)-378.7(broid)-369.4(was)]TJ /F8 1 Tf 17.6477 0 TD (<)Tj /F5 1 Tf .72 0 TD [(2)-168.1(c)0(m)-373.2(for)-371.9(62%;)]TJ -18.3677 -1.1116 TD [(63%)-476.7(had)-476.8(only)-476.8(one)-476.8(broid.)-476.5(The)-478(total)-473.6(broid)-478.8(volume)-475.7(was)]TJ /F8 1 Tf .0173 -1.1116 TD (<)Tj /F5 1 Tf .7142 0 TD (2cm)Tj 7.3823 0 0 6.5614 86.2866 461.0267 Tm (3)Tj 9.843 0 0 9.843 92.7496 456.6613 Tm [(for)-279.7(52%)-280.8(of)-278.6(participants)-287.7(with)-282(broids.)]TJ -2.1081 -1.1116 TD [(In)-411.1(primary)-407.6(analyses,)-412.9(age-adjusted)-415.3(and)-413.4(multivariable)-411.3(ad-)]TJ -1.0137 -1.1174 TD [(justed)-376.5(estimates)-383.3(were)-381.9(very)-374.2(similar)-378.9(\(Table)-378.8(2\).)-380(Self-reported)]TJ 0 -1.1116 TD [(BV)-332.4(had)-332.8(a)-330.6(positive)-332.7(association)-338.2(with)-328.1(broid)-6.5(s)-329.2(though)-329.3(not)-331.7(sig-)]TJ T* [(nicant)-292.4(\(aOR)-283.9(1.21,)-286.6(95%)-286.6(CI)-291.2(0.931.58\).)-284(In)-290.2(secondary)-289.6(analy-)]TJ 0 -1.1174 TD [(ses,)-514.4(we)-516.8(examined)-520.5(size)-519.3(of)-514.8(the)-517.2(largest)-516.9(broid,)-516.8(number)-515.8(of)]TJ 0 -1.1116 TD [(broids)-381.8(and)-378.8(total)-381.4(broid)-380.9(volume)-383.5(as)-377.5(the)-384.7(outcomes)-380.9(\(Fig.)-376.4(1\).)]TJ T* [(Women)-407.6(who)-413.1(reported)-408.6(any)-407.6(RTI)-408.7(had)-407.6(an)-406.5(elevated)-411.1(odds)-407.4(of)-411.1(a)]TJ 0 -1.1174 TD [(small)-393.9(broid)-392.4(\(aOR)-393.3(1.31,)-390.3(95%)-390.3(CI)-394.9(0.931.84\).)-393.5(There)-389.1(was)-396.8(a)]TJ 0 -1.1116 TD [(38%)-234.8(reduction)-242.9(in)-232.7(the)-240.7(odds)-234.6(of)-232.6(having)-238.3(two)-240.4(or)-232.6(more)-237.1(broids)-237.8(for)]TJ T* [(chlamydia)-441.1(\(aOR)-439.4(0.62,)-436.4(95%)-436.3(CI)-435.2(0.400.97\))-436.1(and)-442.2(a)-434.2(46%)-436.3(re-)]TJ 0 -1.1174 TD [(duction)-228(for)-222.1(PID)-228.6(\(aOR)-226.3(0.54,)-229(95%)-223.2(CI)-227.8(0.251.17\).)-220.7(Those)-232.3(with)-224.4(a)]TJ 0 -1.1116 TD [(previous)-286.3(diagnosis)-281.7(of)-278.6(BV)-286.3(had)-280.9(a)-284.5(47%)-280.8(increase)-284.1(in)-278.8(the)-286.8(odds)-280.7(of)]TJ T* [(having)-313.2(two)-309.6(or)-307.4(more)-312(broids)-307(\(aOR)-312.7(1.47,)-309.7(95%)-309.6(CI)-308.5(0.982.21\))]TJ T* [(and)-217.6(a)-209.6(41%)-217.5(increase)-215(in)-215.4(the)-217.7(odds)-211.6(of)-215.3(having)-215.3(a)-209.6(larger)-216.3(total)-220.2(broid)]TJ 0 -1.1174 TD [(volume)-279.8(\()]TJ /F8 1 Tf 3.7899 0 TD ()Tj /F5 1 Tf .72 0 TD (2cm)Tj 7.3823 0 0 6.5614 123.4204 296.6172 Tm (3)Tj 9.843 0 0 9.843 127.1622 292.2519 Tm [(\))-277.5(\(aOR)-283.9(1.41,)-280.9(95%)-280.8(CI)-279.7(0.982.04\).)]TJ -5.6042 -1.1116 TD [(In)-186.5(the)-183.1(secondary)-191.7(analyses)-190.6(that)-184.4(examined)-192.2()50.8(severity)50()-185.4(o)0(f)-186.5(RTI)]TJ -1.0137 -1.1116 TD [(based)-186.2(on)-186.5(number)-187.5(of)-180.7(different)-191(RTIs)-185(we)-188.5(saw)-183.7(an)-187.7(increase)-191.9(in)-180.9(odds)]TJ 0 -1.1174 TD [(of)-238.3(broids)-237.8(for)-233.6(those)-237(with)-235.9(two)-240.4(RTIs)-236.8(\(aOR)-237.8(1.41,)-234.8(95%)-234.8(CI)-239.3(0.99)]TJ 0 -1.1116 TD [(2.01\),)-316.5(but)-314.5(the)-315.6(odds)-315.2(was)-321.9(not)-314.5(elevated)-319(for)-314.3(those)-317.6(with)-316.6(three)-318.9(or)]TJ T* [(more)-237.2(RTIs)-242.6(\(Supplementary)-239.1(Table)-239.5(S4\).)-236.9(Multiple)-236(diagnoses)-242.4(of)]TJ 0 -1.1174 TD [(the)-194.7(same)-192.1(RTI)-195.6(were)-191.9(not)-193.5(associated)-194.1(with)-195.6(higher)-192.2(odds)-194.3(of)-192.2(broids)]TJ 0 -1.1116 TD [(\(Supplementary)-285.1(Table)-285.6(S4\).)]TJ 1.0137 -1.1116 TD [(Th)19.6(e)-244.2()0(r)21(s)0(t)-232.5(s)0(e)14.1(n)0(s)21(i)0(t)20.6(i)0(v)20.7(i)0(t)20.6(y)-243(an)19.7(al)13.8(ys)21(is)20.9(,)-245.3(e)0(x)19.7(c)0(l)19.5(u)0(s)21(i)0(o)20.7(n)-243(of)-238.3(th)20.7(os)21(e)-244.2(w)0(i)19.8(t)0(h)-232.7(a)-244.2(se)14.1(lf)20.7(-)]TJ -1.0137 -1.1174 TD [(re)19.7(po)20.8(rt)15(ed)-205(di)20.7(ag)19.7(no)20.8(si)15.1(s)-214(o)0(f)-209.5(s)0(y)21(p)0(h)20.8(i)0(l)20.6(i)0(s)-209.5(\()]TJ /F10 1 Tf 12.032 0 TD (n)Tj /F8 1 Tf .6566 0 TD (=)Tj /F5 1 Tf .7084 0 TD [(15)20.8(\),)-206.1(re)19.7(su)15.3(lt)20.6(ed)-204.9(in)-209.7(li)20.6(tt)20.6(le)-210.8(ch)19.7(an)19.7(ge)]TJ -13.3971 -1.1116 TD [(in)-342.1(as)19.9(so)15.3(ci)19.6(at)19.5(io)20.7(ns)-341.8(be)19.7(tw)19.8(ee)18.5(n)-352.4(R)0(T)18.6(I)0(s)-341.8(a)0(n)13.9(d)-352.4(b)21(ro)20.9(id)-342.1(pr)20.9(es)19.9(en)19.7(ce)-344.3(\(d)15.1(at)19.6(a)-353.6(n)0(o)20.8(t)]TJ T* [(sh)21(ow)20(n\))15.1(.)-268.4(H)0(o)20(w)0(e)18.8(v)0(e)19.7(r)0(,)-263.7(t)0(h)20.7(e)-273(se)19.9(co)19.7(nd)-261.4(se)14.1(ns)21(it)20.6(iv)20.7(it)20.6(y)-271.8(a)0(n)19.7(a)0(l)19.5(y)0(s)15.3(i)0(s)20.9(,)-268.4(re)14(mo)19.6(va)19.7(l)-271.9(o)0(f)]TJ T* [(th)20.7(os)21(e)-526.4(w)0(i)19.8(t)0(h)-509.2(a)-526.4(se)19.9(lf)20.7(-r)20.9(ep)19.7(or)15.1(te)19.6(d)-519.5(d)0(i)20.7(a)0(g)19.7(n)0(o)20.8(s)0(i)15.1(s)-519.3(of)-514.8(ce)18.5(rv)20.9(ic)19.6(al)-510.3(tr)15(ea)18.5(tm)19.5(en)19.7(t)]TJ 0 -1.1174 TD (\()Tj /F10 1 Tf .3225 0 TD (n)Tj /F8 1 Tf .6566 0 TD (=)Tj /F5 1 Tf .7084 0 TD [(22)20.8(9\))15.1(,)-498.8(r)0(e)14(s)0(u)21(l)0(t)20.6(e)0(d)-492.9(i)0(n)-497.7(a)-503.3(so)21(me)18.4(wh)20(at)-498.8(st)20.9(ro)20.9(ng)20.8(er)-492.9(as)14.1(so)21(ci)19.5(at)19.6(io)20.7(n)-507.9(f)0(o)20.9(r)]TJ -1.6876 -1.1116 TD [(ge)19.7(ni)20.7(ta)19.5(l)-346.8(w)0(a)13(r)0(t)20.7(s)-346.5(\(a)19.7(OR)-338.2(1.)18.5(29)20.8(,)-349(9)0(5)20.8(%)-347.7(CI)-337.3(0.)24.3(76)15.1(2)20.8(.)13.9(1)0(8)20.8(\))0(.)-338.6(O)0(t)19.8(h)0(e)19.7(r)-346.6(RT)18.6(I)-352.4(a)0(s)19.9(-)]TJ T* [(so)21(ci)19.5(at)13.8(io)20.7(ns)-261.2(we)18.8(re)-256.8(es)14.1(se)19.9(nt)20.7(ia)19.6(ll)20.6(y)-271.8(u)0(n)20.8(c)0(h)19.7(a)0(n)19.7(g)0(e)19.7(d)-271.8(\(d)20.9(at)19.5(a)-273(n)0(o)20.8(t)-271.9(sh)21(ow)20(n\))20.9(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 105.959 Tm (Discussion)Tj /F5 1 Tf 9.843 0 0 9.843 72 89.5181 Tm [(In)-405.3(this)-413.4(large)-411.1(study)-408.6(of)-405.3(young)-408.7(African)-414.2(American)-411.9(women,)]TJ -1.0137 -1.1116 TD [(there)-399.6(was)-396.8(little)-400.1(overall)-396.2(support)-399.3(for)-394.9(an)-395(association)-401.5(between)]TJ 0 -1.1174 TD [(womens)-356.3(self-reporte)-10.9(d)-352.4(histories)-356.6(of)-359.3(RTIs)-357.7(and)-355.8(subsequent)-358.7(-)]TJ 0 -1.1116 TD [(broid)-328.1(development.)-325.8(Even)-329.3(those)-323.4(having)-330.4(a)-324.8(history)-324.5(of)-324.7(three)-330.5(or)]TJ 25.504 4.4695 TD [(more)-323.6(different)-329.2(RTIs)-323.2(or)-319(multiple)-328.5(diagnoses)-323(of)-319(the)-327.1(same)-324.6(RTI)]TJ 0 -1.1116 TD [(showed)-267.6(no)-261.4(indication)-261.5(of)-267.1(elevated)-261.4(odds)-263.4(of)-261.4(broids.)-264.3(However,)]TJ 0 -1.1174 TD [(our)-291.3(results)-290.9(for)-285.5(BV)-286.3(and)-286.7(chlamydia)-291.4(are)-293.6(suggestive)-289.7(of)-284.4(possible)]TJ 0 -1.1116 TD [(associations)-264.2(with)-259(broids.)-258.6(Women)-263.6(reporting)-258.9(a)-255.7(history)-261.2(of)-255.6(BV)]TJ T* [(had)-223.3(somewhat)-226.3(elevated)-226.8(odds)-217.3(of)-221(both)-223.4(small)-221.1(and)-223.3(large)-226.8(broids.)]TJ ET 313.058 709.455 239.131 .22675 re f 313.058 241.285 239.131 .22676 re f 449.178 680.201 103.011 .28345 re f 313.058 642.614 239.131 .22681 re f BT /F7 1 Tf 9.845 0 0 9.845 330.5763 725.1022 Tm (Table)Tj /F5 1 Tf 3.0002 0 TD (1.)Tj /F7 1 Tf 1.2496 0 TD [(Distribution)-331.9(of)-337(Covariates)-332.7(by)-335.8(Self-)]TJ -4.7969 -1.0135 TD [(Reported)-332.2(Reproductive)-337.3(Tract)-334.2(Infection)-334.9(Status)]TJ /F10 1 Tf 14.3157 -1.86 TD [(Any)-333.5(reproductive)]TJ .4664 -1.0135 TD [(tract)-334.5(infection)]TJ /F5 1 Tf 7.3837 0 0 6.5625 527.3574 691.1998 Tm (a)Tj /F10 1 Tf 9.845 0 0 9.845 464.655 668.8628 Tm [(Yes)-5036.8(No)]TJ -1.5721 -1.0135 TD (\()Tj /F5 1 Tf .334 0 TD (N)Tj /F8 1 Tf .8868 0 TD (=)Tj /F10 1 Tf .7198 0 TD [(1,172\))-2167.8(\()]TJ /F5 1 Tf 5.0848 0 TD (N)Tj /F8 1 Tf .8868 0 TD (=)Tj /F10 1 Tf .7198 0 TD (482\))Tj -22.4583 -1.0077 TD (Covariate)Tj /F5 1 Tf 14.9204 0 TD (n)Tj /F10 1 Tf .835 0 TD (\(%\))Tj /F5 1 Tf 5.4821 0 TD (n)Tj /F10 1 Tf .835 0 TD (\(%\))Tj /F5 1 Tf -22.0725 -1.9118 TD (Age)Tj 1.002 -1.0077 TD [(2326)-10836.8(343)-331.2(\(29\))-2819.9(157)-331.2(\(33\))]TJ 0 -1.0135 TD [(2730)-10836.8(396)-331.2(\(34\))-2819.9(170)-331.2(\(35\))]TJ /F8 1 Tf .167 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(31)-11450(433)-331.2(\(37\))-2819.9(155)-331.2(\(32\))]TJ -1.8888 -1.3129 TD (Education)Tj /F8 1 Tf 1.169 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(High)-333.2(school/GED)-5173.7(229)-331.2(\(20\))-2819.9(133)-331.2(\(28\))]TJ -.8868 -1.0135 TD [(Some)-334.4(college)-339(or)-330.2(technical)-2686.1(639)-331.2(\(55\))-2819.9(201)-331.2(\(42\))]TJ /F8 1 Tf .167 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(Bachelors)-8443.9(303)-331.2(\(26\))-2819.9(148)-331.2(\(31\))]TJ -.8868 -1.0077 TD [(Missing)-11617(1)]TJ -1.002 -1.3187 TD [(BMI)-338.8(\(kg/m)]TJ 7.3837 0 0 6.5625 358.5259 538.866 Tm (2)Tj 9.845 0 0 9.845 362.2109 534.5006 Tm (\))Tj -3.9907 -1.0077 TD [(1524)-10836.8(212)-331.2(\(18\))-2819.9(111)-331.2(\(23\))]TJ 0 -1.0135 TD [(2529)-10836.8(266)-331.2(\(23\))-3320.9(78)-330.2(\(16\))]TJ T* [(3034)-10836.8(236)-331.2(\(20\))-3320.9(84)-330.2(\(17\))]TJ /F8 1 Tf .167 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(35)-11450(458)-331.2(\(39\))-2819.9(209)-331.2(\(43\))]TJ -1.8888 -1.3129 TD [(Alcohol)-337.5(at)-337.3(age)-333.6(when)-334.2(drinking)-336.5(the)-332.6(most)]TJ 7.3837 0 0 6.5625 471.5148 486.0849 Tm (b)Tj 9.845 0 0 9.845 322.9228 471.7416 Tm [(Low)-11504.8(255)-331.2(\(22\))-2819.9(172)-331.2(\(36\))]TJ 0 -1.0135 TD [(Moderate)-9496.7(386)-331.2(\(33\))-2819.9(157)-331.2(\(33\))]TJ 0 -1.0077 TD [(Heavy)-10724.8(531)-331.2(\(45\))-2819.9(153)-331.2(\(32\))]TJ -1.002 -1.3187 TD (Parity)Tj 1.002 -1.0077 TD [(Nulliparous)-8610.7(409)-331.2(\(35\))-2819.9(218)-331.2(\(45\))]TJ 0 -1.0135 TD [(Parous)-10619.8(763)-331.2(\(65\))-2819.9(264)-331.2(\(55\))]TJ -1.002 -1.3187 TD (Depo-Provera)Tj 1.002 -1.0077 TD [(Never)-336.3(used)-8723.4(638)-331.2(\(54\))-2819.9(300)-331.2(\(62\))]TJ 0 -1.0135 TD [(Ever)-334.5(used)-9276.2(534)-331.2(\(46\))-2819.9(182)-331.2(\(38\))]TJ -1.002 -1.3187 TD [(Age)-339(at)-331.6(menarche)-336.3(\(years\))]TJ 1.002 -1.0077 TD [(710)-11336.8(206)-331.2(\(18\))-3320.9(96)-330.2(\(20\))]TJ 0 -1.0135 TD [(1119)-10836.8(966)-331.2(\(82\))-2819.9(386)-331.2(\(80\))]TJ -1.002 -1.313 TD [(Sex)-338(partners)-332.7(before)-336.5(age)-339.3(20)-330.2(years)]TJ /F8 1 Tf 1.169 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(1)-11950(203)-331.2(\(17\))-2819.9(190)-331.2(\(39\))]TJ -.8868 -1.0135 TD [(25)-11836.8(588)-331.2(\(50\))-2819.9(237)-331.2(\(49\))]TJ /F8 1 Tf .167 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(6)-11950(379)-331.2(\(32\))-3320.9(55)-330.2(\(11\))]TJ -.8868 -1.0077 TD [(Missing)-11617(2)]TJ -1.002 -1.3187 TD [(Age)-339(at)-331.6(rst)-337.8(sex)-332.2(\(years\))]TJ /F8 1 Tf 1.169 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(14)-11450(407)-331.2(\(35\))-3320.9(83)-330.2(\(17\))]TJ -.8868 -1.0077 TD [(1516)-10836.8(426)-331.2(\(36\))-2819.9(143)-331.2(\(30\))]TJ /F8 1 Tf .167 -1.0135 TD ()Tj /F5 1 Tf .7198 0 TD [(17)-11450(338)-331.2(\(29\))-2819.9(254)-331.2(\(53\))]TJ -.8868 -1.0135 TD [(Missing)-11617(1)-5817.1(2)]TJ 8.7511 0 0 8.7511 321.0519 229.4361 Tm [(Any)-335.6()60.9(prefer)-338.3(not)-332.1(to)-333.3(answer)59.9()-334.3(response)-338.2(was)-328.7(coded)-333.4(as)-334.1(missing.)]TJ 6.5633 0 0 5.8334 321.0519 224.3905 Tm (a)Tj 8.7511 0 0 8.7511 323.9999 220.4787 Tm [(Includes)-753.2(pelvic)-757.3(inammatory)-757.9(disease,)-758(chlamydia,)-755.2(bacterial)]TJ -1.2503 -1.0236 TD [(vaginosis,)-667.8(trichomonas,)-664.4(gonorrhea,)-665.4(genital)-670.6(herpes,)-662.2(and)-664.9(genital)]TJ T* [(warts.)-339.3(Two)-338.3(participants)-337.8(were)-335.4(not)-338.6(included)-340.3(because)-338.3(they)-332.1(responded)]TJ T* [()54.4(prefer)-325.3(not)-319.2(to)-320.3(answer)59.8()-321.3(for)-324(at)-321.5(least)-322.8(one)-321.6(RTI)-317.6(and)-321.6(reported)-319.3()54.4(no)59.4()-321.3(for)]TJ T* [(other)-336(RTIs;)-331.8(thus,)-332(their)-334.7()54.4(any)-332(RTI)54.3()-334.3(status)-331.8(could)-331(not)-332.1(be)-335.7(determined.)]TJ 6.5633 0 0 5.8334 321.0519 179.5464 Tm (b)Tj 8.7511 0 0 8.7511 324.3401 175.6346 Tm [(Low)-318.8(drinkers)-323(were)-322.4(those)-322.9(who)-322.7(never)-319(had)-321.6(10)-321.6(or)-320.1(more)-323(drinks)-319.1(in)-320.3(a)]TJ -1.2892 -1.0236 TD [(year.)-238.6(Heavy)-238.5(drinkers)-238.8(were)-238.2(those)-238.7(who)-238.5(usually)-235.1(drank)-240.1(6)-232.1(o)0(r)-242.4(more)-232.3(drinks)]TJ T* [(on)-263.3(days)-267(when)-264.4(they)-260.9(drank)-259.5(or)-268.3(drank)-259.5(4)]TJ /F8 1 Tf 14.6281 0 TD (+)Tj /F5 1 Tf .9782 0 TD [(drinks)-267.3(per)-261.9(sitting)-263.7(at)-263.2(least)-264.5(2)-264.4(t)0(o)]TJ -15.6064 -1.0236 TD [(3)-335.7(times)-332.1(a)-336.9(month.)-330(Moderate)-332.1(drinkers)-335.9(were)-335.4(all)-332(others.)]TJ .9135 -1.0236 TD [(BMI,)-463.8(body)-455.3(mass)-463.8(index;)-458.1(GED,)-466.3(general)-459.1(education)-463.4(degree;)-459.1(IQR,)]TJ -.9135 -1.0236 TD [(interquartile)-335.5(range.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (492)Tj 47.327 0 TD [(MOORE)-330.9(ET)-338.7(AL.)]TJ ET endstream endobj 63 0 obj <>stream 0 0 0 1 k /GS1 gs 59.754 733.549 490.167 .22675 re f 59.754 340.214 490.167 .28348 re f 208.687 714.274 108.85 .22681 re f 350.022 696.529 76.309 .28351 re f 458.872 696.529 91.049 .28351 re f 59.754 676.686 490.167 .22681 re f 59.754 627.987 490.167 .28345 re f BT /F7 1 Tf 9.845 0 0 9.845 121.833 749.1967 Tm 0 Tc 0 Tw (Table)Tj /F5 1 Tf 3.0002 0 TD (2.)Tj /F7 1 Tf 1.2496 0 TD [(Adjusted)-331.9(Odds)-338.3(Ratios)-334.8(for)-332.2(Fibroids)-335.8(According)-333(to)-330(Self-Reported)-338.1(History)]TJ 6.559 -1.0135 TD [(of)-337(Reproductive)-331.6(Tract)-334.2(Infections)]TJ /F10 1 Tf 1.8197 -1.86 TD (Fibroids)Tj 11.782 -1.8197 TD [(Age-adjusted)-4536(Multivariable-adjusted)]TJ -14.5288 -.0058 TD [(Yes)-5900.5(No)]TJ /F5 1 Tf -.858 -1.0135 TD (N)Tj /F8 1 Tf .8811 0 TD (=)Tj /F10 1 Tf .7198 0 TD (363)Tj /F5 1 Tf 5.2 0 TD (N)Tj /F8 1 Tf .8868 0 TD (=)Tj /F10 1 Tf .7198 0 TD (1,293)Tj -23.7367 -1.0135 TD [(Reproductive)-340.4(tract)-334.5(infections)]TJ /F5 1 Tf 15.7093 0 TD (n)Tj /F10 1 Tf .835 0 TD (\(%\))Tj /F5 1 Tf 6.3459 0 TD (n)Tj /F10 1 Tf .835 0 TD [(\(%\))-5388.2(OR)-332.2(\(95%)-333.2(CI\))-6309.6(OR)-332.2(\(95%)-333.2(CI\))]TJ /F5 1 Tf -23.7252 -1.9061 TD [(Any)-337.8(RTI)]TJ 7.3837 0 0 6.5625 95.8677 668.5793 Tm (a)Tj 9.845 0 0 9.845 69.6189 654.2361 Tm [(Yes)-12575.7(262)-337(\(72\))-4052.2(910)-331.2(\(70\))-3303.6(1.05)-334.6(\(0.801.36\))-5365.3(1.15)-334.6(\(0.871.52\))]TJ 7.3837 0 0 6.5625 535.8046 658.6014 Tm (b)Tj 9.845 0 0 9.845 69.6189 644.3148 Tm [(No)-12907.7(101)-337(\(28\))-4052.2(381)-331.2(\(30\))]TJ 0 -1.0135 TD [(Missing)-19586.8(2)]TJ -1.002 -1.9061 TD (PID)Tj 1.002 -1.0135 TD [(Yes)-13076.7(34)-336(\(9\))-4552.2(128)-331.2(\(10\))-3303.6(0.90)-334.6(\(0.601.35\))-5365.3(0.94)-334.6(\(0.621.43\))]TJ 7.3837 0 0 6.5625 535.8046 609.9589 Tm (b)Tj 9.845 0 0 9.845 69.6189 595.6156 Tm [(No)-12907.7(329)-337(\(91\))-3303.6(1,164)-329.8(\(90\))]TJ T* [(Missing)-19586.8(1)]TJ -1.002 -1.0077 TD (Chlamydia)Tj 1.002 -1.0135 TD [(Yes)-12575.7(125)-337(\(34\))-4052.2(503)-331.2(\(39\))-3303.6(0.85)-334.6(\(0.661.09\))-5365.3(0.92)-334.6(\(0.701.21\))]TJ 7.3837 0 0 6.5625 535.8046 570.1038 Tm (c)Tj 9.845 0 0 9.845 69.6189 555.7605 Tm [(No)-12907.7(238)-337(\(66\))-4052.2(788)-331.2(\(61\))]TJ T* [(Missing)-19586.8(2)]TJ -1.002 -1.0077 TD [(Bacterial)-343.4(vaginosis)]TJ 1.002 -1.0135 TD [(Yes)-12575.7(147)-337(\(41\))-4052.2(477)-331.2(\(37\))-3303.6(1.14)-334.6(\(0.891.45\))-5365.3(1.21)-334.6(\(0.931.58\))]TJ 7.3837 0 0 6.5625 535.8046 530.2487 Tm (c)Tj 9.845 0 0 9.845 69.6189 515.9054 Tm [(No)-12907.7(216)-337(\(60\))-4052.2(815)-331.2(\(63\))]TJ 0 -1.0077 TD [(Missing)-19586.8(1)]TJ -1.002 -1.0135 TD (Trichomonas)Tj 1.002 -1.0135 TD [(Yes)-12575.7(116)-337(\(32\))-4052.2(414)-331.2(\(32\))-3303.6(0.90)-334.6(\(0.701.16\))-5365.3(0.90)-334.6(\(0.681.20\))]TJ 7.3837 0 0 6.5625 535.8046 490.3936 Tm (c)Tj 9.845 0 0 9.845 69.6189 476.0503 Tm [(No)-12907.7(247)-337(\(68\))-4052.2(878)-331.2(\(68\))]TJ 0 -1.0077 TD [(Missing)-19586.8(1)]TJ -1.002 -1.0135 TD (Gonorrhea)Tj 1.002 -1.0135 TD [(Yes)-13076.7(62)-336(\(17\))-4052.2(261)-331.2(\(20\))-3303.6(0.81)-334.6(\(0.601.11\))-5365.3(0.94)-334.6(\(0.671.33\))]TJ 7.3837 0 0 6.5625 535.8046 450.5385 Tm (c)Tj 9.845 0 0 9.845 69.6189 436.1952 Tm [(No)-12907.7(301)-337(\(83\))-3303.6(1,031)-329.8(\(80\))]TJ 0 -1.0077 TD [(Missing)-19586.8(1)]TJ -1.002 -1.0135 TD [(Genital)-338.9(herpes)]TJ 1.002 -1.0135 TD [(Yes)-13076.7(31)-336(\(9\))-4552.2(112)-331.2(\(9\))-3803.6(0.93)-334.6(\(0.611.42\))-5365.3(0.89)-334.6(\(0.581.39\))]TJ 7.3837 0 0 6.5625 535.8046 410.6833 Tm (c)Tj 9.845 0 0 9.845 69.6189 396.3401 Tm [(No)-12907.7(332)-337(\(91\))-3303.6(1,180)-329.8(\(91\))]TJ 0 -1.0077 TD [(Missing)-19586.8(1)]TJ -1.002 -1.0135 TD [(Genital)-338.9(warts)]TJ 1.002 -1.0135 TD [(Yes)-13076.7(28)-336(\(8\))-5053.2(85)-330.2(\(7\))-3803.6(1.10)-334.6(\(0.701.73\))-5365.3(1.09)-334.6(\(0.681.74\))]TJ 7.3837 0 0 6.5625 535.8046 370.8282 Tm (c)Tj 9.845 0 0 9.845 69.6189 356.5416 Tm [(No)-12907.7(335)-337(\(92\))-3303.6(1,207)-329.8(\(93\))]TJ T* [(Missing)-19586.8(1)]TJ 8.7511 0 0 8.7511 67.748 328.422 Tm [(Any)-335.6()60.9(prefer)-338.3(not)-332.1(to)-333.3(answer)59.9()-334.3(response)-331.7(was)-335.2(coded)-333.4(as)-334.1(missing.)]TJ 6.5633 0 0 5.8334 67.748 323.3196 Tm (a)Tj 8.7511 0 0 8.7511 70.696 319.4645 Tm [(Includes)-332.1(pelvic)-336.2(inammatory)-330.4(disease,)-336.9(chlamydia,)-334.1(bacterial)-332.3(vaginosis,)-331(trichomonas,)-334(gonorrhea,)-335(genital)-333.8(herpes,)-331.8(and)-334.6(genital)-333.8(warts.)]TJ 6.5633 0 0 5.8334 67.748 314.3621 Tm (b)Tj 8.7511 0 0 8.7511 71.0362 310.507 Tm [(Logistic)-332.4(regression)-333.2(model)-335(adjusted)-332.2(for)-330.5(age)-335.7(\(continuous\),)-332.7(education,)-336.5(body)-332.2(mass)-334.2(index,)-327.1(alcohol,)-337.7(menarche,)-331(parity,)-336.2(DepoProvera)-332.1(use.)]TJ 6.5633 0 0 5.8334 67.748 305.4046 Tm (c)Tj 8.7511 0 0 8.7511 70.696 301.5495 Tm [(Logistic)-267.6(regression)-261.9(model)-270.2(adjusted)-267.5(for)-265.7(age)-264.5(\(continuous\),)-267.9(education,)-265.3(body)-261(mass)-269.4(index,)-268.8(alcohol,)-259.9(menarche,)-272.7(parity,)-265(DepoProvera)-267.3(use,)-264.3(and)]TJ -1.2503 -1.0301 TD [(other)-336(RTIs)-334.2(except)-332.1(PID)-334(and)-334.6(the)-333.3(RTI)-330.5(being)-337.4(evaluated.)]TJ .9134 -1.0236 TD [(CI,)-331.7(condence)-337.4(interval;)-328.7(OR,)-335.4(odds)-330.6(ratio;)-338.8(PID,)-330.2(pelvic)-336.2(inammatory)-330.4(disease;)-338.3(RTI,)-333.2(reproductive)-334(tract)-329.4(infection.)]TJ ET q 360.926 0 0 198.142 59.754 55.502 cm /Im1 Do Q BT /F6 1 Tf 9.845 0 0 9.845 433.1337 230.6267 Tm [(FIG.)-336.7(1.)]TJ /F5 1 Tf 4.1174 0 TD [(Ad)20.2(ju)20.9(st)21(ed)-262.3(od)21(ds)]TJ -4.1174 -1.0077 TD [(ra)19.9(ti)20.7(os)-260.9(fo)21(r)-271.6(s)0(i)21(z)0(e)-263.5(o)0(f)-261.1(t)0(h)20.9(e)-272.8(la)19.7(rg)21(es)20(t)]TJ 0 -1.0135 TD [(b)21.2(ro)21(id)15.1(,)-268.3(n)0(u)21.1(m)0(b)19.9(e)0(r)-262.3(o)0(f)-261.1()0(b)21.2(r)0(o)21(i)0(d)20.9(s)0(,)]TJ T* [(an)19.9(d)-271.6(t)0(o)20.9(t)0(a)19.7(l)-271.8(b)21.2(ro)21(id)-261.3(vo)21.1(lu)20.9(me)-263.5(ac)18.7(-)]TJ T* [(co)19.9(rd)21(in)15.1(g)-265.9(t)0(o)-261.3(s)0(e)20(l)0(f)20.9(-)0(r)15.3(e)0(p)19.9(o)0(r)21.1(t)0(e)19.7(d)-271.6(hi)20.9(s-)]TJ 0 -1.0077 TD 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[(in)20.9(de)19.9(x,)-263.5(al)19.7(co)19.9(ho)21.1(l,)-257.9(me)18.7(na)19.9(rc)14.1(he)19.9(,)]TJ 0 -1.0077 TD [(pa)19.9(ri)20.9(ty)15.1(,)-268.3(D)0(e)19.1(p)0(o)21.1(-)0(P)21.2(r)0(o)21(v)0(e)14.1(r)0(a)-256.5(u)0(s)15.5(e)0(,)-258.9(a)0(n)19.9(d)]TJ 0 -1.0135 TD [(al)19.7(l)-271.8(o)0(t)20.9(h)0(e)19.9(r)-271.7(re)19.9(pr)21.1(od)21.1(uc)14.1(ti)20.7(ve)-256.5(tr)15.1(ac)18.7(t)]TJ T* [(in)20.9(fe)19.9(ct)13.9(io)20.9(ns)-260.9(\(R)20.1(TI)19.9(s\))-260.9(ex)19.9(ce)18.7(pt)]TJ T* [(pe)19.9(lv)20.9(ic)-262.5(in)20.9(a)20.1(mm)18.7(at)19.7(or)21(y)-271.6(d)0(i)20.9(s)0(e)14.3(a)0(s)20.1(e)]TJ 0 -1.0077 TD [(an)19.9(d)-271.6(t)0(h)20.9(e)-272.8(RT)18.9(I)-265.9(b)0(e)14.1(i)0(n)20.9(g)-265.9(ev)19.9(al)14(ua)19.9(te)19.7(d.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 297.4109 34.2425 Tm (493)Tj ET endstream endobj 64 0 obj <>stream AdobedC        s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?Nlٳf͛6lٳf͛6lٰ6ieq..f`v")p?27o_4Lj+ #!H)p?27o_4Lj+ #!H)p?27o_4Lj+ #!H)p?27o_4Lj+ 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[(su)21(pp)20.8(or)15.1(te)19.6(d)-312.1(b)0(y)-307.5(o)0(u)20.8(r)-312.1(ob)20.8(se)19.9(rv)15.1(at)19.5(io)20.7(n)-312.1(t)0(h)20.7(a)0(t)-308.8(b)0(o)20.8(t)0(h)-301.8(l)0(o)15(w)0(e)18.8(r)-312.1(ag)19.7(e)-313.3(a)0(t)-308.8()0(r)21(s)0(t)-307.4(s)0(e)19.9(x)]TJ 0 -1.1116 TD [(an)19.7(d)-317.9(h)0(i)14.9(g)0(h)20.8(e)0(r)-308.6(n)0(u)20.8(m)0(b)19.6(e)0(r)19.7(s)-317.7(of)-313.2(se)19.9(x)-317.9(p)0(a)19.7(r)0(t)20.7(n)0(e)13.9(r)0(s)-307.2(w)0(e)18.8(r)0(e)-308.6(a)0(s)19.9(s)0(o)15.3(c)0(i)19.5(a)0(t)19.5(e)0(d)-308.6(w)0(i)19.8(t)0(h)-313.3(i)0(n)20.7(-)]TJ T* [(cr)19.7(ea)18.5(se)19.9(d)-415.8(r)0(e)19.7(p)0(o)20.8(r)0(t)20.7(i)0(n)20.7(g)-410(of)-399.6(in)15(fe)19.7(ct)19.5(io)20.7(n.)-402(Fi)20.9(na)19.7(ll)20.6(y,)-401.9(ou)20.8(r)-410(s)0(a)19.9(m)0(p)19.6(l)0(e)-400.9(i)0(s)-405.3(n)0(o)20.8(t)-410.2(a)]TJ T* [(re)19.7(pr)20.9(es)14.1(en)19.7(ta)19.5(ti)20.6(ve)-274.1(po)20.8(pu)20.8(la)13.8(ti)20.6(on)20.8(-b)20.9(as)19.9(ed)-274.1(sa)14.1(m)15(p)0(l)14.9(e)-284.5(of)-272.9(wo)20(me)18.4(n.)-275.2(Ho)20(we)18.8(ve)19.7(r,)]TJ 0 -1.1174 TD -.0274 Tc [(because)-317.6(it)-322.4(c)4.9(a)-.9(ptures)-322(early)-316.5(broid)-316.5(d).3(evelopment)-316.6(\().3(most)-316.6(of)-322.2(th)6.1(e)-323.4(w)-.6(o-)]TJ 0 -1.1116 TD -.0276 Tc [(men)-247.6(with)-247.6(broids)-247.4(had)-247.6(s).3(mall)-247.7().3(broids\),)-249.9(our)-247.5(sample)-248.7(was)-247.4(a)-248.7(relevant)]TJ T* [(one)-185.3(for)-184.1(investigating)-184.1(t).1(he)-185.3(po)6(s)-5.4(s).4(ible)-179.5(r)-5.5(o)6(le)-185.3(of)-184.1(RTIs)-183.9(in)-184.1(the)-185.3(hypothesized)]TJ 0 -1.1174 TD 0 Tc [(broid)-288.8(pathog)-7.9(enesis)-285.1(involv)-6.9(ing)-285.7(aberra)-10(nt)-284.6(tissue)-284.1(repair)-9(.)]TJ 7.3823 0 0 6.5614 271.729 280.1763 Tm [(21,)-9.4(22)]TJ 9.843 0 0 9.843 72 264.8692 Tm [(Our)-280.6(study)-281.9(has)-286.5(several)-287.6(strengths.)-285.1(We)-282.1(used)-281.8(enrollment)-285.6(data)]TJ -1.0137 -1.1116 TD [(from)-575.8(an)-573.6(ongoing)-578.1(prospective)-574.3(study)-575.7(with)-575.7(a)-578.2(standardized)]TJ 0 -1.1174 TD [(measure)-490.3(of)-491.7(broid)-484.6(status)-491.5(based)-491.5(on)-486(systematic)-493.8(ultrasound)]TJ 0 -1.1116 TD [(screening)-318.6(rather)-320(than)-316.7(broids)-318.5(clinically)-314.7(detected)-324.7(because)-317.4(of)]TJ T* [(symptoms.)-216(The)-213(number,)-219.8(diameter,)-213(and)-217.6(volume)-210.7(of)-215.3(the)-217.7(broids)]TJ 0 -1.1174 TD [(were)-330.1(systematically)-338.3(measured,)-333.5(so)-330.3(we)-332.5(were)-330.1(able)-329.4(to)-330.6(examine)]TJ 0 -1.1116 TD [(associations)-287.2(with)-287.8(these)-284.2(separate)-289.8(characteristics.)-286.2(Twenty-two)]TJ T* [(percent)-472.1(\(22%\))-473(of)-468.7(our)-464(cohort)-474.4(of)-468.7(young)-466.3(African)-471.8(American)]TJ T* [(women)-429.2(had)-430.7(broids)-427.9(at)-423.9(ultrasound)-432.7(screening,)-431.4(a)-422.7(prevalence)]TJ 0 -1.1174 TD [(which)-347.5(falls)-352.3(within)-347.7(the)-350.2(range)-347.6(of)-347.7(prior)-345.4(U.S.)-349.6(studies)-348.6(that)-345.6(con-)]TJ 0 -1.1116 TD [(ducted)-435.3(ultrasound)-432.7(screening.)]TJ 7.3823 0 0 6.5614 178.8094 159.6472 Tm (2,10,29,38)Tj 9.843 0 0 9.843 214.4692 155.2818 Tm [(Our)-430.4(sample)-436.3(size)-432.9(was)]TJ -15.4878 -1.1116 TD [(sufcient)-248.3(to)-238.5(provide)-245.1(good)-240.6(precision)-248.4(for)-239.4(the)-246.5(main)-243.1(hypotheses.)]TJ 0 -1.1174 TD [(We)-293.6(also)-287.7(had)-292.4(extensive)-289.9(data)-289.1(to)-290.3(assess)-296.1(potential)-289.2(confounding,)]TJ 0 -1.1116 TD [(very)-466.3(minimal)-466.7(missing)-463.8(data,)-465.3(and)-465.2(we)-465(conducted)-468.6(sensitivity)]TJ T* [(analyses)-282.7(to)-284.6(evaluate)-284.4(potential)-283.5(bias.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 84.0189 Tm (Conclusions)Tj /F5 1 Tf 9.843 0 0 9.843 72 67.5779 Tm [(Overall,)-337.1(the)-332.9(studies)-337(of)-330.5(RTIs)-334.7(and)-332.8(broids,)-339.2(including)-334(ours,)]TJ -1.0137 -1.1116 TD [(reveal)-263.6(no)-267.1(strong)-259.9(associations.)-267.6(Our)-263.3(study)-264.6(was)-264.3(the)-263.8(rst)-263.3(to)-261.5(look)]TJ 25.504 67.9184 TD [(at)-205.1(the)-200.4(relationship)-205.9(between)-208(RTIs)-202.2(and)-200.3(broid)-202.4(size,)-205.9(number)-204.8(and)]TJ 0 -1.1174 TD [(total)-202.9(volume,)-202.6(but)-199.3(most)-195.6(studies)-204.6(have)-202.6(been)-196.8(limited)-200.7(by)-198(the)-200.4(use)-200.1(of)]TJ 0 -1.1116 TD [(self-reporte)-10.9(d)-260.3(exposure)-258.6(histories)-264.5(of)-261.4(these)-261.2(often)-260.2(asymptoma)-8.9(tic)]TJ T* [(infections.)-345.2(The)-339.7(small)-336.3(study)-339.5(that)-339.9(looked)-342(for)-337.3(pathogens)-340.5(in)-336.4(-)]TJ T* [(broid)-328.1(tissue)-330.2(did)-326(no)-324.7(serological)-332.6(assessment)-326.1(to)-330.6(biochemically)]TJ 0 -1.1174 TD [(measure)-542.1(past)-535.4(exposure)-535(to)-532.2(infection.)]TJ 7.3823 0 0 6.5614 463.8046 674.7021 Tm (10)Tj 9.843 0 0 9.843 476.4471 670.3369 Tm [(Future)-537.6(studies)-538.6(are)]TJ -16.5995 -1.1116 TD [(needed)-367.2(to)-365.2(take)-364(the)-367.5(next)-362.8(step)-368.4(and)-361.6(use)-367.1(serology)-367(to)-359.4(better)-366.3(in-)]TJ T* [(vestig)-7.8(ate)-282.2(associations)-281.5(between)-282.9(RTIs)-282.9(and)-280.9(broids.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 313.0582 626.3431 Tm (Acknowledgments)Tj /F5 1 Tf 9.843 0 0 9.843 323.0361 609.9022 Tm [(This)-362.6(research)-358.8(was)-362.3(supported)-362.3(by)-359.3(the)-355.9(Intramural)-360.3(Resea)-9.8(rch)]TJ -1.0137 -1.1174 TD [(Progra)-7.5(m)-457.3(o)0(f)-457.2(the)-459.6(NIH,)-457.7(National)-461.7(Institute)-460.6(of)-462.9(Environmental)]TJ 0 -1.1116 TD [(Healt)-9(h)-346.7(Sciences)-353.1(\(10-E-N044\).)-351.6(Funding)-347.5(also)-351.1(came)-348.9(from)-351.1(the)]TJ T* [(American)-267.9(Recovery)-266.7(and)-257.9(Reinvestment)-266.8(Act)-258.9(funds)-264.5(designated)]TJ 0 -1.1174 TD [(for)-285.5(National)-283.1(Institute)-282.1(of)-278.6(Health)-286.5(research.)]TJ 1.0137 -1.1116 TD [(The)-241.8(authors)-244.9(thank)-242.9(Drs.)-243.5(Lauren)-246.2(Wilson)-245.1(and)-240.6(Grace)-246(Kissling)]TJ -1.0137 -1.1116 TD [(for)-291.2(review)-292.1(of)-290.1(an)-291.3(earlier)-293.6(draft)-294.7(of)-284.4(the)-292.6(manuscript.)-294.5(Dr.)-288.7(Christie)]TJ 0 -1.1174 TD [(Barke)-8.8(r-Cummings)-383(of)-382.3(Social)-389.2(and)-384.6(Scientic)-387.8(Systems)-384.1(in)-388.2(Re-)]TJ 0 -1.1116 TD [(search)-367(Triangle)-358.1(Park,)-360.1(NC,)-358.9(managed)-363.8(the)-355.9(overall)-361.6(study)-356.8(data.)]TJ T* [(Dr.)-334.8(Ganesa)-333.3(Wegienka)-337.2(is)-330.4(the)-332.9(research)-335.7(collaborator)-333.8(at)-331.8(Henry)]TJ T* [(Ford)-430.4(Health)-424.8(System)-429.2(in)-422.8(Detroit,)-428.2(Tracy)-429.5(Cooper)-423.5(is)-428.3(the)-425.1(head)]TJ 0 -1.1174 TD [(sonographer)-313.7(there,)-310.9(and)-315.5(Karen)-308.2(Bourgeois)-311.5(manages)-317.5(the)-309.9(study)]TJ 0 -1.1116 TD [(staff)-283(there.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 313.0582 456.3778 Tm [(Author)-338.7(Disclosure)-336.7(Statement)]TJ /F5 1 Tf 9.843 0 0 9.843 323.0361 439.9369 Tm [(No)-279.5(competing)-284.4(nancial)-283.1(interests)-288.7(exist.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 313.0582 417.8833 Tm (References)Tj /F5 1 Tf 9.2951 0 0 9.2951 317.707 401.8393 Tm [(1.)-500.4(Stewart)-338.3(EA.)-333.2(Uterine)-341.5(broids.)-334.2(Lancet)-332(2001;357:293298.)]TJ 0 -1.1284 TD [(2.)-500.4(Baird)-285.9(D,)-288.5(Dunson)-282.1(DB,)-287.3(Hill)-287.1(MC,)-285(Cousins)-284(D,)-288.5(Schectman)-288.4(JM.)]TJ 1.2503 -1.1223 TD [(High)-367.5(cumulative)-365.7(incidence)-370.7(of)-362.5(uterine)-364.4(leiomyoma)-367.6(in)-365.7(black)]TJ 0 -1.1284 TD [(and)-346.2(white)-346.9(women:)-341.1(Ultrasound)-349.1(evidence.)-346.8(Am)-343(J)-346.9(Obstet)-346.2(Gy-)]TJ 0 -1.1223 TD [(necol)-337.9(2003;188:100107.)]TJ -1.2503 -1.1284 TD [(3.)-500.4(Pritts)-387.7(EA,)-382(Parker)-388.9(WH,)-384.4(Olive)-383.5(DL.)-388.1(Fibroids)-382.5(and)-388.9(infertility:)]TJ 1.2503 -1.1223 TD [(An)-300.7(updated)-295.5(systematic)-302.9(review)-299.3(of)-295.4(the)-296.8(evidence.)-304.2(Fertil)-295.2(Steril)]TJ 0 -1.1284 TD (2009;91:12151223.)Tj -1.2503 -1.1223 TD [(4.)-500.4(Lippman)-280.6(SA,)-273.2(Warner)-274.4(M,)-273.9(Samuels)-278.8(S,)-271.5(Olive)-279.8(D,)-270.2(Vercellini)-284(P,)]TJ 1.2503 -1.1284 TD [(Eskenazi)-404.6(B.)-401.5(Uterine)-396.4(broids)-401.2(and)-401.1(gynecologic)-397.3(pain)-400.7(symp-)]TJ 0 -1.1223 TD [(toms)-511(in)-505.9(a)-510.6(population-based)-514.8(study.)-505.6(Fertil)-514.8(Steril)-508.7(2003;80:)]TJ 0 -1.1284 TD (14881494.)Tj -1.2503 -1.1223 TD [(5.)-500.4(Wegienka)-584.8(G,)-581.2(Baird)-584.8(DD,)-582.9(Hertz-Picciotto)-586.4(I,)-575.9(et)-583.3(al.)-583.4(Self-)]TJ 1.2503 -1.1284 TD [(reported)-416.2(heavy)-405.6(bleeding)-417.1(associated)-411.8(with)-409.6(uterine)-413.2(leiomyo-)]TJ 0 -1.1223 TD [(mata.)-337.4(Obstet)-334(Gynecol)-339.8(2003;101:431437.)]TJ -1.2503 -1.1284 TD [(6.)-500.4(Cardozo)-321.5(ER,)-312(Clark)-316.4(AD,)-320.7(Banks)-313.8(NK,)-314.6(Henne)-315.7(MB,)-321.6(Stegmann)]TJ 1.2503 -1.1223 TD [(BJ,)-388.5(Segars)-391.8(JH.)-385.3(The)-384.7(estimated)-395.1(annual)-386.9(cost)-387.6(of)-386.9(uterine)-388.7(leio-)]TJ 0 -1.1284 TD [(myomata)-624(in)-621.8(the)-620.1(United)-621.5(States.)-620.1(Am)-617.5(J)-621.4(Obstet)-620.6(Gynecol)]TJ 0 -1.1223 TD (2012;206:211.e211219.)Tj -1.2503 -1.1284 TD [(7.)-500.4(Marsh)-377.7(EE,)-382.3(Bulun)-370.9(SE.)-377.2(Steroid)-381.3(hormones)-378.4(and)-376.7(leiomyomas.)]TJ 1.2503 -1.1223 TD [(Obstet)-340.1(Gynecol)-333.7(Clin)-333.6(North)-333.4(Am)-336.9(2006;33:5967.)]TJ -1.2503 -1.1284 TD [(8.)-500.4(Wright)-274.8(KN,)-271.9(Laufer)-272(MR.)-272.8(Leiomyomas)-271.7(in)-274.2(adolescents.)-271.8(Fertil)]TJ 1.2503 -1.1223 TD [(Steril)-337.9(2011;95:2434.e1517.)]TJ -1.2503 -1.1284 TD [(9.)-500.4(Cramer)-292.7(SF,)-280.6(Patel)-291.4(A.)-282.4(The)-287.1(frequency)-286.9(of)-283.2(uterine)-291.2(leiomyomas.)]TJ 1.2503 -1.1223 TD [(Am)-336.9(J)-334.7(Clin)-333.6(Pathol)-336.2(1990;94:435438.)]TJ -1.7505 -1.1284 TD [(10.)-500.5(Laughlin)-372.1(SK,)-364.7(Schroeder)-369.1(JC,)-364.1(Baird)-365.2(DD.)-369.5(New)-367.6(directions)-369.4(in)]TJ 1.7505 -1.1284 TD [(the)-424.9(epidemiology)-422.8(of)-423.5(uterine)-425.3(broids.)-425.7(Semin)-421.6(Reprod)-420.8(Med)]TJ 0 -1.1223 TD (2010;28:204217.)Tj -1.7505 -1.1284 TD [(11.)-500.5(Wise)-574.9(LA,)-565(Palmer)-568.5(JR,)-571.5(Harlow)-571.1(BL,)-568.2(et)-565.1(al.)-571.2(Reproductive)]TJ 1.7505 -1.1223 TD [(factors,)-433.5(hormonal)-433.6(contraception,)-440.2(and)-431.6(risk)-428.4(of)-429.6(uterine)-437.5(leio-)]TJ 0 -1.1284 TD [(myomata)-709.4(in)-707.2(African-American)-711.2(women:)-707.1(A)-709.2(prospective)]TJ 0 -1.1223 TD [(study.)-334.8(Am)-336.9(J)-334.7(Epidemiol)-334.6(2004;159:113123.)]TJ -1.7505 -1.1284 TD [(12.)-500.5(Ma)14.5(rs)22.7(ha)19.9(ll)-401.7(LM)23(,)-408.7(S)0(p)21.2(i)0(e)20.5(g)0(e)13.8(l)12.6(m)12.5(a)0(n)-400.9(D)0(,)-398.2(G)0(o)22.5(l)0(d)18.6(m)12.5(an)-400.9(M)12.8(B)0(,)-401.4(e)0(t)-394.3(a)0(l)14.4(.)-402.6(A)-410.4(p)0(r)21.8(o)0(-)]TJ 1.7505 -1.1223 TD [(sp)18.9(ec)15.7(t)12.6(i)0(v)18.6(e)-272.7(st)19.5(ud)18(y)-274.6(o)0(f)-264.9(r)0(e)23.7(p)0(r)15.7(o)0(d)18(u)0(c)19.9(t)12.6(iv)18.6(e)-272.7(f)0(a)17.6(c)0(t)20.5(o)0(r)15.7(s)-273.7(a)14(n)0(d)-268.6(o)0(r)21.8(a)0(l)-266.2(c)14(on)18(tr)16.3(a)14(c)0(e)15.7(p)0(t)18.6(i)12.6(ve)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (494)Tj 47.327 0 TD [(MOORE)-330.9(ET)-338.7(AL.)]TJ ET endstream endobj 73 0 obj <>stream /GS1 gs BT /F5 1 Tf 9.2951 0 0 9.2951 76.0252 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(use)-442.9(in)-438.9(relati)-9.9(on)-439.4(to)-432.8(the)-443.2(risk)-440.6(of)-441.8(uterine)-443.6(leiomy)-9.6(omata.)-441.3(Ferti)-9(l)]TJ 0 -1.1223 TD [(Ster)-9.4(il)-334.6(1998;7)-6.4(0:432)-6.4(439.)]TJ -1.7505 -1.1284 TD [(13.)-500.5(Edwards)-540.8(DV.)-540.2(Association)-538.7(of)-539.3(age)-539.5(at)-540.6(menarche)-538.3(with)-537.7(in-)]TJ 1.7505 -1.1223 TD [(creasing)-490.4(number)-494.9(of)-484.4(broids)-492.7(in)-487.6(a)-486.2(cohort)-488.7(of)-490.5(women)-487.9(who)]TJ 0 -1.1283 TD [(underwent)-360.7(standardized)-360.4(ultrasound)-353.6(assessment.)-363.4(Am)-355.2(J)-353(Epi-)]TJ 0 -1.1223 TD [(demiol)-339(2013;178:426433.)]TJ -1.7505 -1.1284 TD [(14.)-500.5(Marshall)-460.5(LM,)-459(Spiegelman)-460.6(D,)-459.2(Manson)-454.8(JE,)-458.8(et)-455.3(al.)-461.4(Risk)-455.2(of)]TJ 1.7505 -1.1223 TD [(uterine)-382.6(leiomyomata)-389.8(among)-382.7(premenopausal)-385.1(women)-384.2(in)-377.9(re-)]TJ 0 -1.1284 TD [(lation)-436.4(to)-432.8(body)-433.6(size)-440.6(and)-431.6(cigarette)-439.6(smoking.)-432.3(Epidemiology)]TJ 0 -1.1223 TD (1998;9:511517.)Tj -1.7505 -1.1284 TD [(15.)-500.5(Wise)-452.9(LA,)-449.1(Palmer)-452.6(JR,)-449.5(Harlow)-449.1(BL,)-452.3(et)-449.2(al.)-449.2(Risk)-449.1(of)-447.9(uterine)]TJ 1.7505 -1.1223 TD [(leiomyomata)-444.7(in)-438.9(relation)-437.1(to)-438.9(tobacco,)-446.2(alcohol)-441.3(and)-437.7(caffeine)]TJ 0 -1.1284 TD [(consumption)-473(in)-469.3(the)-473.7(Black)-470.8(Womens)-474.1(Health)-467.1(Study.)-472.8(Hum)]TJ T* [(Reprod)-335.4(2004;19:17461754.)]TJ -1.7505 -1.1223 TD [(16.)-500.5(Lumbiganon)-250.5(P,)-247.1(Rugpao)-253.8(S,)-247.1(Phandhu-fung)-245.3(S,)-253.2(Laopaiboon)-249.1(M,)]TJ 1.7505 -1.1284 TD [(Vudhikamraksa)-528.9(N,)-526.3(Werawatakul)-525.7(Y.)-526.3(Protective)-529.9(effect)-523.8(of)]TJ 0 -1.1223 TD [(depot-medroxyprogesterone)-549.9(acetate)-551.5(on)-543.1(surgically)-546.3(treated)]TJ 0 -1.1284 TD [(uterine)-333.9(leiomyomas:)-329.8(a)-333.7(multicentre)-331(casecontrol)-336.2(study.)-328.7(Br)]TJ 0 -1.1223 TD [(J)-334.7(Obstet)-334(Gynaecol)-338(1996;103:909914.)]TJ -1.7505 -1.1284 TD [(17.)-500.5(Nagata)-478(C,)-474.6(Nakamura)-474.7(K,)-477.5(Oba)-469.8(S,)-472.8(Hayashi)-479.2(M,)-475.2(Takeda)-472.8(N,)]TJ 1.7505 -1.1223 TD [(Yasuda)-308.8(K.)-306.8(Association)-307(of)-307.6(intakes)-306.3(of)-307.6(fat,)-305.3(dietary)-309.5(bre,)-302.8(soya)]TJ 0 -1.1284 TD [(isoavones)-449.6(and)-443.8(alcohol)-441.3(with)-446.2(uterine)-443.6(broids)-443.9(in)-445(Japanese)]TJ 0 -1.1223 TD [(women.)-335.5(Br)-336.7(J)-334.7(Nutr)-333.3(2009;101:14271431.)]TJ -1.7505 -1.1284 TD [(18.)-500.5(Witherspoon)-474(JT,)-471(Butler)-468.5(VW.)-475.9(The)-470.1(etiology)-467.2(of)-472.2(uterine)-474.1(-)]TJ 1.7505 -1.1223 TD [(broids)-355.5(with)-354.8(special)-359.3(reference)-358.7(to)-353.5(the)-351.7(frequency)-360.1(of)-356.4(their)-353.8(oc-)]TJ 0 -1.1284 TD [(currence)-327.6(in)-323(the)-321.2(Negro:)-325.6(A)-325(hypothesis.)-326.1(Surg)-323(Gynecol)-321.5(Obstet)]TJ 0 -1.1223 TD (1934;58:4.)Tj -1.7505 -1.1284 TD [(19.)-500.5(Centers)-673.8(for)-669.9(Disease)-677.7(Control)-665.7(and)-669.5(Prevention.)-672.7(Sexually)]TJ 1.7505 -1.1223 TD [(transmitted)-496.7(disease)-493.1(surveillance)-494(2012.)-494.7(Atlanta:)-490.7(U.S.)-492.8(De-)]TJ 0 -1.1284 TD [(partment)-248.2(of)-246.6(Health)-247.6(and)-248.6(Human)-250(Services,)-249.4(2013.)-244.6(Available)-245.6(at)]TJ 0 -1.1223 TD -.0322 Tc (www.cdc.gov/st)Tj 6.0382 0 TD -.0329 Tc (d/stats12/Surv)Tj 5.2697 0 TD -.0326 Tc [(2012.pdf)-254.6(Accessed)-258.4(J)-1.4(uly)-258.4(3)3.9(0,)-258.3(2014.)]TJ -13.0585 -1.1284 TD 0 Tc [(20.)-500.5(Centers)-564(for)-566.2(Disease)-567.9(Control)-562(and)-559.7(Prevention.)-562.9(Incidence,)]TJ 1.7505 -1.1223 TD [(prevalence,)-414.7(and)-413.3(cost)-412(of)-411.3(sexually)-410.1(transmitted)-417.4(infections)-412.1(in)]TJ 0 -1.1284 TD [(the)-333.4(United)-334.9(States.)-339.6(Atlanta:)-332.1(U.S.)-334.3(Department)-339.7(of)-332(Health)-339.1(and)]TJ 0 -1.1223 TD [(Human)-243.9(Services,)-243.3(2013.)-238.5(Available)-245.6(at)-241.8(www.cdc.gov/std/st)12.8(at)20.5(s/)]TJ 0 -1.1284 TD [(STI)-7.5(-Estim)-8.7(ates-Fact-)-11.6(She)-7.5(et-Feb-2)-10.4(013.pdf)-320.4(Accesse)-11.5(d)-317.3(June)-321.1(20,)]TJ 0 -1.1223 TD [(20)-6.4(13.)]TJ -1.7505 -1.1284 TD [(21.)-500.5(Leppert)-354.6(PC,)-355.7(Catherino)-357.2(WH,)-353.9(Segars)-355.2(JH.)-348.7(A)-355.5(new)-353.9(hypothesis)]TJ 1.7505 -1.1223 TD [(about)-370.3(the)-370(origin)-368(of)-368.6(uterine)-376.6(broids)-364.6(based)-374.2(on)-366.2(gene)-374.9(expres-)]TJ 0 -1.1284 TD [(sion)-596.8(proling)-590.8(with)-592.6(microarrays.)-592.7(Am)-593.1(J)-590.9(Obstet)-596.2(Gynecol)]TJ 0 -1.1223 TD (2006;195:415420.)Tj -1.7505 -1.1284 TD [(22.)-500.5(Wegienka)-414(G.)-410.4(Are)-411.1(uterine)-407(leiomyoma)-410.3(a)-413(consequence)-412.1(of)-405.2(a)]TJ 1.7505 -1.1223 TD [(chronically)-832.1(inammatory)-830.5(immune)-833.1(system?)-830(Med)-827.3(Hy-)]TJ 0 -1.1284 TD [(potheses)-336.6(2012;79:226231.)]TJ -1.7505 -1.1223 TD [(23.)-500.5(Faerstein)-511.1(E,)-502.2(Szklo)-507.4(M,)-505.7(Rosenshein)-506.3(NB.)-506.9(Risk)-504(factors)-512.7(for)]TJ 1.7505 -1.1284 TD [(uterine)-272.9(leiomyoma:)-275.7(A)-270.1(practice-based)-273.8(case-control)-277.3(study.)-273.8(II.)]TJ T* [(Atherogenic)-462.2(risk)-458.9(factors)-457.8(and)-456(potential)-458.8(sources)-461.3(of)-453.9(uterine)]TJ 0 -1.1223 TD [(irritation.)-336.9(Am)-336.9(J)-334.7(Epidemiol)-334.6(2001;153:1119.)]TJ -1.7505 -1.1284 TD [(24.)-500.5(Moore)-384.7(KR,)-384.9(Smith)-386.3(JS,)-380.5(Laughlin-Tommaso)-392.1(SK,)-383(Baird)-383.5(DD.)]TJ 1.7505 -1.1223 TD [(Cervical)-251.5(neoplasia-related)-248.7(factors)-244.4(and)-242.5(decreased)-249.4(prevalence)]TJ 0 -1.1284 TD [(of)-466.1(uterine)-461.9(broids)-468.3(among)-461.9(a)-461.8(cohort)-464.3(of)-466.1(African)-466.4(American)]TJ 0 -1.1223 TD [(women.)-335.5(Fertil)-337.9(Steril)-331.8(2014;101:208214.)]TJ -1.7505 -1.1284 TD [(25.)-500.5(Dueholm)-359.5(M,)-353.2(Lundorf)-355.2(E,)-355.9(Hansen)-357.6(ES,)-358.9(Ledertoug)-354.9(S,)-356.9(Olesen)]TJ 1.7505 -1.1223 TD [(F.)-405.7(Accuracy)-406.1(of)-405.2(magnetic)-408.7(resonance)-409.9(imaging)-406.2(and)-401.1(transva-)]TJ 0 -1.1284 TD [(ginal)-705.2(ultrasonography)-702.4(in)-701.1(the)-699.4(diagnosis,)-704.1(mapping,)-699.6(and)]TJ 0 -1.1223 TD [(measurement)-500.3(of)-496.6(uterine)-492.4(myomas.)-497.4(Am)-495.5(J)-493.3(Obstet)-492.6(Gynecol)]TJ 0 -1.1284 TD (2002;186:409415.)Tj -1.7505 -1.1223 TD [(26.)-500.5(Mo)18.8(s)12.9(h)0(e)19.9(s)0(h)-286.1(M)0(,)-286.1(P)0(e)17(d)0(d)24.1(a)0(d)19.9(a)-297.1(SD)19.6(,)-292.8(C)0(o)19.3(o)0(p)18(e)14(r)-301.3(T)0(,)-282.7(B)0(a)21.2(i)0(r)16.3(d)-292.9(D.)-288.5(In)21.8(t)12.6(r)0(a)17.6(o)0(b)24.1(s)0(e)20.8(r)0(v)15.7(e)14(r)]TJ 1.7505 -1.1284 TD [(va)19.9(ri)22.4(ab)19.9(il)19.2(i)12.6(t)0(y)-219.3(i)0(n)-219.3()0(b)21.2(r)0(o)21.8(i)0(d)-219.3(s)0(i)19.5(z)0(e)-222.2(m)12.5(ea)21.8(su)18.9(re)23.7(me)20.3(nt)18.6(s)12.9(:)-231.3(Es)17(t)12.6(i)12.6(m)0(a)20.3(t)0(e)20.5(d)-231.9(e)14(f)0(f)19.5(e)0(c)15.7(t)12.6(s)-231(o)0(n)]TJ 0 -1.1223 TD [(as)20.8(se)14.7(s)12.9(s)12.9(i)0(n)18.6(g)-372.2(b)21.2(ro)21.8(i)12.6(d)-372.2(gr)21.8(ow)22.5(th)18.6(.)-372.1(J)-371.3(Ul)23.1(tr)16.3(a)14(s)0(o)18.9(u)0(n)24.1(d)-372.2(Me)20.6(d)-372.2(2)0(0)24.1(1)0(4)18(;)12.6(33)18(:)12.6(1)0(2)24.1(1)0(7)18()]TJ 0 -1.1284 TD [(12)18(24)24.1(.)]TJ 25.263 67.5246 TD [(27.)-500.5(Bradshaw)-407.7(CS,)-404.5(Morton)-404.4(AN,)-400(Hocking)-408.8(J,)-401.9(et)-406.5(al.)-400.4(High)-404.1(recur-)]TJ 1.7505 -1.1223 TD [(rence)-485.3(rates)-485.7(of)-484.4(bacterial)-488.4(vaginosis)-490.5(over)-482.8(the)-485.9(course)-486.5(of)-484.4(12)]TJ 0 -1.1284 TD 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