Congratulations to the Lab of , an MHI member and Assistant Professor of Biomedical Engineering; Member, Cell Biology and Physiology Curriculum, 黑料网 Medicine; Member, Comparative Medicine Institute, NCSU, for publishing vascular malformation-on-chip model for drug screening in Science Advances.
For this manuscript, titled 鈥淢icrophysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation鈥�, , a biomolecular engineering (BME) postdoctoral fellow in the Polacheck Lab, led a highly collaborative effort that involved contributions from nearly every member of the Polacheck Lab, along with in Pediatric Hematology and Oncology at 黑料网, in Applied Math, and at the Eshleman School of Pharmacy. By developing a microfluidic model of vascular malformations, Dr. Aw and colleagues demonstrate novel signaling mechanisms in lesion formation and test potential interventions. The work is featured in the 17 February 2023, Volume 9, Issue 7, of the journal Science Advances and can be now.