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SUMMARY:DOM Medicine Grand Rounds- Dr. Andrea Coviello presents: "Treating Obesity: 3 Things I Want You to Know."
DESCRIPTION:As a board-certified endocrinologist and obesity medicine specialist\, my research focus has been on the neuroendocrine control of reproduction and metabolism and the influence of reproductive hormones on metabolism and cardiovascular disease. This project aligns with my research goals as it focuses on the treatment of obesity and related endocrinology disorders in relation to newer prescribed incretins and I am excited to be part of this team in my role as a co-Investigator. \nMy research has encompassed clinical and genetic epidemiology studies in population-based cohorts such as the Framingham Heart Study (FHS) and NHANES as well as translational clinical research. I am working with the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium as a FHS investigator on the genetic influences of reproductive traits such as menopause as well as circulating gonadal and adrenal sex hormones and their relationships to health and chronic disease. My clinical research has included clinical trials of testosterone therapy in men.  In women\, I have studied the metabolic disorders associated with androgen excess in women with polycystic ovary syndrome (PCOS) as well as the metabolic and cardiovascular sequelae of higher androgens in women of white European ancestry (1RO1HL094755-01A2). I mentor a junior investigator with a BIRCWH K12 (Duke) examining the role of sex steroids in hidradenitis in women with PCOS. \nMy clinical trial work has shifted to focus on industry sponsored trials in obesity\, diabetes\, lipid disorders and fatty liver disease. I have clinical expertise in the treatment of obesity and related endocrinology disorders combined with research expertise in reproductive endocrinology in the effects of sex steroids on health and disease. I am currently developing a clinical trial program in obesity and obesity related disorders in the Department of Medicine’s Clinical Research Unit. As the Director of the ������ Weight Management Program with clinical expertise in the treatment of obesity and related endocrinology disorders I am uniquely qualified to facilitate research\, specifically clinical trials\, with obesity and obesity related metabolic disorders.
URL:/medicine/event/dom-medicine-grand-rounds-dr-andrea-coviello-presents-treating-obesity-3-things-i-want-you-to-know/
LOCATION:Room 4008 Old Clinic Auditorium\, Chapel Hill\, NC\, United States
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20241219T120000
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SUMMARY:DOM Medicine Grand Rounds- Dr. Klara Klein presents: "Rethinking Type 2 Diabetes: From Research to Practice."
DESCRIPTION:I am a MD/PhD trained investigator with an interest in conducting stakeholder-engaged clinical trials to advance the care of people living with diabetes and chronic kidney disease. My research path has spanned experiences in small molecule synthesis and drug development\, molecular biology\, animal models of disease\, and most recently clinical trials. My early focus was on basic research\, but I sought collaborative mentors who were interested in basic mechanisms involved in drug discovery that would ultimately impact human health. My early work resulted in six publications (three first author publications\, including a cover article for Developmental Cell) and was funded by a Ruth L. Kirschstein Individual Predoctoral National Research Service Award (NIH NHLBI F30 HL118932\, PI: Klein\, Mentor: Caron). More importantly\, my basic science training brought unique understanding of the drug development process and influenced my career goal to work in clinical trials\, where I can bring bench research to the bedside.  \nAs an endocrinology fellow\, I transitioned from basic science to diabetes clinical trials. During this transition\, I have continued to publish successfully. I have been fortunate to work with pharmaceutical companies on both large and small clinical trials\, but I have been consistently disappointed in the lack of representation in clinical research and the time it takes for effective therapies to reach patients at need. As a diabetes clinical trialist\, I have become passionate about closing the “research-to-practice-gap” through the conduct of stakeholder-engaged clinical trials. I have also become increasingly interested in leveraging the electronic medical record to expand clinical trial reach and to encourage early use of state-of-the-art therapeutics. While I have gained important experience as an investigator on industry sponsored clinical trials\, I require foundational training in stakeholder engagement\, implementation science\, and informatics in order to independently design\, execute\, and implement stakeholder-engaged clinical trials that are broadly representative of the disease population. \nAs a tenure-track junior faculty member (starting in July 2022) with 75% protected time guaranteed and a start-up package\, I aim to conduct new research with potential to (1) improve reach and representativeness of the clinical trials conducted in the Endocrine Diabetes and Obesity Clinical Research Unit (EnDO CRU) and (2) hasten to acceptance of effective therapeutics. To do so\, I will focus on to elucidating the setting-specific barriers and feasibility of enrolling patients from North Carolina community-based practices and develop a tool to facilitate identification and enrollment of eligible patients across North Carolina. This work has potential to enhance enrollment efficiency\, increase trial participant representativeness\, and deepen community practitioner buy-in\, all essential factors in promoting post-trial adoption of effective therapies. \nI have assembled a mentorship team that consists of leaders in stakeholder engagement and implementation science\, clinical informatics\, and diabetes and kidney disease clinical trials. Dr. Jenny Flythe (stakeholder engagement and implementation science) will serve as my primary mentor. Drs. Emily Pfaff (clinical informatics) and Buse (clinical trials\, diabetes) will serve as co-mentors. Under their guidance\, I will pursue coursework in implementation science that will ultimately help me to engage key stakeholders to design and implement studies that best serve the patient population and the providers who care for them. I will also pursue training in basic informatics to facilitate effective collaboration with data scientists to develop tools aimed at increasing study population diversity and encourage early use of approved therapies. My mentorship team is enthusiastic about my proposed work and has the expertise required to ensure success. Each is deeply committed to training me to become an independent investigator. Completion of these aims and training objectives will cement the pathway toward becoming an independent human subjects researcher capable of developing novel therapeutics that are quickly and broadly distributed to improve both diabetes and advanced kidney disease care. \n 
URL:/medicine/event/dom-medicine-grand-rounds-dr-klara-klein-presents-rethinking-type-2-diabetes-from-research-to-practice/
LOCATION:Room 4008 Old Clinic Auditorium\, Chapel Hill\, NC\, United States
CATEGORIES:Medicine Grand Rounds
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