{"id":498,"date":"2010-07-07T20:25:00","date_gmt":"2010-07-08T00:25:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/core-facilities\/clinicaltranslationalcore\/"},"modified":"2025-03-27T13:13:32","modified_gmt":"2025-03-27T17:13:32","slug":"clinicaltranslationalcore","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/core-facilities\/clinicaltranslationalcore\/","title":{"rendered":"CF Clinical Translational Core"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p class=\"lead\">Director: <a href=\"https:\/\/www.med.unc.edu\/medicine\/pulmonary\/people\/donaldson\/\">Scott H. Donaldson, MD<\/a><\/p>\n<div>\n<h2><strong>MISSION<\/strong><\/h2>\n<p>The development and validation of biomarkers that reflect different aspects of cystic fibrosis are of paramount importance to continued efforts to understand disease biology and the development of new therapeutics. Further, translation of basic research ideas into clinical studies that test their validity and clinical utility is of paramount importance to scientific advances in CF. The CF Clinical Translation Core was established to facilitate these goals.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1310\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2010\/07\/9f8b5c07-f294-4131-af3b-339991cc39da.jpg\" alt=\"Photograph of a 19F-MRI, and 19F-MRI ventilation images from healthy and CF subjects. 19F-MRI\" width=\"500\" height=\"375\" srcset=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2010\/07\/9f8b5c07-f294-4131-af3b-339991cc39da.jpg 400w, https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2010\/07\/9f8b5c07-f294-4131-af3b-339991cc39da-300x225.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"image-inline alignnone\" title=\"Mucociliary Clearance Imaging, via gamma scintigraphy\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Slide2.jpg\" alt=\"Photograph of a patient undergoing muociliary clearance imaging via gamma scintigraphy, accompanied by images resulting from this process, a diagram of a lung, and a graph with Percent Clearance as the Y-axis and Time (Minutes) as the X-axis.\" width=\"960\" height=\"720\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><strong>SERVICES<\/strong><\/h2>\n<ul>\n<li>Biospecimen collection and repository\n<ul>\n<li>Cystic fibrosis (and disease control) sputum samples<\/li>\n<li>Exhaled breath condensate<\/li>\n<li>Excess clinical samples from bronchoscopy<\/li>\n<li>Nasal epithelial samples<\/li>\n<li>Rectal biopsy samples<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>Development of Novel Lung Imaging Outcomes\n<ul>\n<li>Mucociliary clearance, via gamma Scintigraphy<\/li>\n<li>Lung ventilation imaging, via 19F-MRI<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>Regulatory and Biostatistics\n<ul>\n<li>Consultative advice for clinical study design<\/li>\n<li>Guidance through required regulatory step before study initiation<\/li>\n<li>Design of databases<\/li>\n<li>Statistical analysis plans, power calculations, and data analysis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><strong>PERSONNEL<\/strong><\/h2>\n<ul>\n<li>Scott H. Donaldson, MD \u2013 (Pulmonary, Core Director)<\/li>\n<li>William Bennett, PhD (Mucociliary Clearance)<\/li>\n<li>Yueh Lee, MD, PhD (Radiology)<\/li>\n<li>Jennifer Goralski, MD (Pulmonary)<\/li>\n<li>Agathe Ceppe (Biostatistics)<\/li>\n<li>Evan Dellon, MD (Gastroenterology)<\/li>\n<li>Margaret Powell\u00a0(Research Assistant)<\/li>\n<\/ul>\n<h2><strong>SUPPORT<\/strong><\/h2>\n<p>Work in this core is funded by the NIH\/NIDDK (Grant # P30 DK065988)<\/p>\n<h2><strong><span style=\"text-decoration: underline\">Contact Information<\/span><\/strong><\/h2>\n<p>Scott H. Donaldson, MD<br \/>\nProfessor of Medicine<br \/>\n2204 Marsico Hall, CB#7248<br \/>\nThe University of North Carolina at Chapel Hill<br \/>\nChapel Hill, NC 27599<br \/>\nPhone: 984-974-9198<br \/>\nFax: 984-974-2968<\/p>\n<p><a class=\"email-link\" title=\"\" href=\"mailto:scott_donaldson@med.unc.edu\" target=\"_self\" rel=\"noopener\">scott_donaldson@med.unc.edu<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Director: Scott H. Donaldson, MD MISSION The development and validation of biomarkers that reflect different aspects of cystic fibrosis are of paramount importance to continued efforts to understand disease biology and the development of new therapeutics. Further, translation of basic research ideas into clinical studies that test their validity and clinical utility is of paramount &hellip; <a href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/core-facilities\/clinicaltranslationalcore\/\" aria-label=\"Read more about CF Clinical Translational Core\">Read more<\/a><\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":62,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-498","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CF Clinical Translational Core | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/core-facilities\/clinicaltranslationalcore\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CF Clinical Translational Core | Marsico Lung Institute\" \/>\n<meta property=\"og:description\" content=\"Director: Scott H. 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