Marsico Lung Institute /marsicolunginstitute/ Fri, 23 May 2025 20:17:35 +0000 en-US hourly 1 Button Interviewed for Curious by Nature Podcast /marsicolunginstitute/button-interviewed-for-curious-by-nature-podcast/ Fri, 23 May 2025 19:30:10 +0000 /marsicolunginstitute/?p=6680 Brian Button, PhD, was interviewed for a Curious by Nature podcast episode called “Taking Mucus from Disgusting to Fascinating.” You can listen to the podcast at the Curious by Nature website here.

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Brian Button, PhD, was interviewed for a Curious by Nature podcast episode called “Taking Mucus from Disgusting to Fascinating.”

You can listen to the podcast at the Curious by Nature website .

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Schworer Searches for Origins of Asthma /marsicolunginstitute/schworer-searches-for-origins-of-asthma/ Fri, 23 May 2025 18:51:59 +0000 /marsicolunginstitute/?p=6678 Stephen Schworer, MD, PhD, a NC TraCS K Scholar, wants to know how lung tissue becomes asthmatic, in the hope of preventing the disease from developing. Read the full story on the North Carolina Translational and Clinical Sciences Institute website here.

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, a NC TraCS K Scholar, wants to know how lung tissue becomes asthmatic, in the hope of preventing the disease from developing.

Read the full story on the North Carolina Translational and Clinical Sciences Institute website .

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Drummond’s COPD Research Highlighted in Recent Articles /marsicolunginstitute/drummond-consulted-for-article-on-drug-treatment-for-copd/ Fri, 23 May 2025 14:14:13 +0000 /marsicolunginstitute/?p=6670 Research conducted by M. Bradley Drummond, MD, MHS, has been highlighted in a number of recent articles concerning drugs for the treatment of COPD. You can read the articles at the links below: “Dupixent: The First FDA-Approved Biologic Drug to Treat Uncontrolled COPD” can be read on the Verywell Health website here. “Early Studies Suggest … Read more

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Research conducted by M. Bradley Drummond, MD, MHS, has been highlighted in a number of recent articles concerning drugs for the treatment of COPD. You can read the articles at the links below:

“Dupixent: The First FDA-Approved Biologic Drug to Treat Uncontrolled COPD” can be read on the Verywell Health website .

“Early Studies Suggest GLP-1s May Improve COPD Symptoms” can also be read on the Verywell Health website .

“Ensifentrine Monotherapy Improves Dyspnea, Health-Related Quality of Life in COPD” can be read on the HCP Live website .

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Conlon’s Lab Targets Staph Infections /marsicolunginstitute/conlons-lab-targets-staph-infections/ Thu, 01 May 2025 17:56:09 +0000 /marsicolunginstitute/?p=6665 Brian Conlon, PhD, and his lab are researching ways to help antibiotics fight deadly “persister” bacteria. Read the full story here.

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Brian Conlon, PhD, and his lab are researching ways to help antibiotics fight deadly “persister” bacteria.

Read the full story .

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Marsico Lung Institute Publications for March 2025 /marsicolunginstitute/marsico-lung-institute-publications-for-march-2025/ Thu, 03 Apr 2025 19:14:13 +0000 /marsicolunginstitute/?p=6632 Marsico Lung Institute faculty, postdoc, student, and collaborator publications for March 2025 included papers appearing in the American Journal of Respiratory & Critical Care Medicine, Journal of Clinical Microbiology, and Journal of Medical Internet Research. Check out the full list below: Liu CM, Fischer JL, Lee MJ, Mace JC, Kimple AJ, Markarian K, Alt JA, … Read more

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Marsico Lung Institute faculty, postdoc, student, and collaborator publications for March 2025 included papers appearing in the American Journal of Respiratory & Critical Care Medicine, Journal of Clinical Microbiology, and Journal of Medical Internet Research. Check out the full list below:

  1. Liu CM, Fischer JL, Lee MJ, Mace JC, Kimple AJ, Markarian K, Alt JA, Bodner TE, Chowdhury NI, Chung SY, Eshaghian PH, Gao YA, Getz AE, Hwang PH, Khanwalkar A, Lee JT, Li DA, Norris M, Nayak JV, Overdevest JB, Owens C, Patel ZM, Pappas LE, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Turner GA, Wang MB, Taylor-Cousar JL, Saavedra MT, Beswick DM. . Laryngoscope. 2025 Mar 29. doi: 10.1002/lary.32155. Epub ahead of print. PMID: 40156369.
  2. Alam F, Li Y, Vogt MR. J Virol. 2025 Mar 25:e0184624. doi: 10.1128/jvi.01846-24. Epub ahead of print. PMID: 40130875.
  3. Pasnick S, Keller JM, Dela Cruz CS, Gross JE, Carlos Iii WG, Maves R, Jamil S, Collins B, Sundar K. . Am J Respir Crit Care Med. 2025 Mar 25. doi: 10.1164/rccm.202503-0694ST. Epub ahead of print. PMID: 40130871.
  4. Bridges Y, Souza V, Cortes KG, Haendel M, Harris NL, Korn DR, Marinakis NM, Matentzoglu N, McLaughlin JA, Mungall CJ, Odell A, Osumi-Sutherland D, Robinson PN, Smedley D, Jacobsen JOB. . BMC Bioinformatics. 2025 Mar 22;26(1):87. doi: 10.1186/s12859-025-06105-4. PMID: 40121479; PMCID: PMC11929307.
  5. Matentzoglu N, Bello SM, Stefancsik R, Alghamdi SM, Anagnostopoulos AV, Balhoff JP, Balk MA, Bradford YM, Bridges Y, Callahan TJ, Caufield H, Cuzick A, Carmody LC, Caron AR, de Souza V, Engel SR, Fey P, Fisher M, Gehrke S, Grove C, Hansen P, Harris NL, Harris MA, Harris L, Ibrahim A, Jacobsen JOB, Köhler S, McMurry JA, Munoz-Fuentes V, Munoz-Torres MC, Parkinson H, Pendlington ZM, Pilgrim C, Robb SMC, Robinson PN, Seager J, Segerdell E, Smedley D, Sollis E, Toro S, Vasilevsky N, Wood V, Haendel MA, Mungall CJ, McLaughlin JA, Osumi-Sutherland D. T. Genetics. 2025 Mar 17;229(3):iyaf027. doi: 10.1093/genetics/iyaf027. PMID: 40048704; PMCID: PMC11912833.
  6. Konstantinidis I, Papageorgiou SN, Zou RH, Ronit A, Drummond MB, Kunisaki KM, Crothers K, Nouraie SM, Morris A. . AIDS. 2025 Mar 13. doi: 10.1097/QAD.0000000000004179. Epub ahead of print. PMID: 40080108.
  7. Barjaktarevic I, Hixson R, Zhuang Z, Buhr RG, Tejwani V, Barr RG, Bateman LA, Bhatt SP, Bleecker ER, Cooper CB, Curtis JL, Drummond MB, Fortis S, Ghosh AJ, Han M, Hansel NN, Hoffman EA, Ohar J, Martinez FJ, Meyers DA, Paine R 3rd, Pirozzi CS, Sandhaus R, Strange C, Tashkin DP, Wells JM, Woodruff P, Ortega VE. . Ann Am Thorac Soc. 2025 Mar 11. doi: 10.1513/AnnalsATS.202411-1209OC. Epub ahead of print. PMID: 40068143.
  8. Czech MM, Cuellar-Rodriguez J, Kwon-Chung KJ, Stock F, Aneke CI, Olivier KN, Fennelly KP, Gea-Banacloche J, Zerbe CS, Freeman AF, Holland SM, Lionakis MS, Seyedmousavi A. . J Clin Microbiol. 2025 Mar 7:e0155024. doi: 10.1128/jcm.01550-24. Epub ahead of print. PMID: 40052805.
  9. Mandel HL, Shah SN, Bailey LC, Carton T, Chen Y, Esquenazi-Karonika S, Haendel M, Hornig M, Kaushal R, Oliveira CR, Perlowski AA, Pfaff E, Rao S, Razzaghi H, Seibert E, Thomas GL, Weiner MG, Thorpe LE, Divers J; RECOVER EHR Cohort. O. J Med Internet Res. 2025 Mar 5;27:e59217. doi: 10.2196/59217. PMID: 40053748; PMCID: PMC11923460.
  10. Stapleton AL, Kimple A, Goralski JL, Beswick DM, Gupta A, Li DA, Branstetter BF, Nouraie SM, Shaffer AD, Senior B, Zemke AC. . Int Forum Allergy Rhinol. 2025 Mar 2:e23555. doi: 10.1002/alr.23555. Epub ahead of print. PMID: 40024881.
  11. Martin B, DeWitt PE, Russell S, Haendel M, Sanchez-Pinto N, Albers DJ, Jhaveri RR, Moffitt R, Bennett TD; N3C Consortium. . Pediatr Infect Dis J. 2025 Mar 1;44(3):217-227. doi: 10.1097/INF.0000000000004575. PMID: 39951364; PMCID: PMC11812670.
  12. Williams CL, Billings J, McGowan H, McDevitt R, Esther CR Jr, McKinzie CJ, Wilson WS, Kam CW. . Pediatr Pulmonol. 2025 Mar;60(3):e71038. doi: 10.1002/ppul.71038. PMID: 40067072.
  13. Lukasiewicz AJ, Leistra AN, Hoefner L, Monzon E, Gode CJ, Zorn BT, Janssen KH, Yahr TL, Wolfgang MC, Contreras LM. . Front Mol Biosci. 2025 Feb 20;12:1493891. doi: 10.3389/fmolb.2025.1493891. PMID: 40051501; PMCID: PMC11882435.

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Button & Livraghi-Butrico Study Reveals Possible Effects of Air Quality Changes Associated with Global Warming on Human Airways /marsicolunginstitute/button-livraghi-butrico-study-reveals-possible-effects-of-air-quality-changes-associated-with-global-warming-on-human-airways/ Thu, 20 Mar 2025 19:04:55 +0000 /marsicolunginstitute/?p=6555 A study now published in Nature Communications Earth & Environment reveals how global warming could exacerbate lung diseases by dehydrating and inflaming human airways. Marsico Lung Institute members Brian Button, PhD, and Alessandra Livraghi-Butrico, PhD, are senior author and co-author, respectively. Read the full story at the Health Newsroom here and at Newswise.com … Read more

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A study now published in Nature Communications Earth & Environment reveals how global warming could exacerbate lung diseases by dehydrating and inflaming human airways. Marsico Lung Institute members Brian Button, PhD, and Alessandra Livraghi-Butrico, PhD, are senior author and co-author, respectively.

Read the full story at the Health Newsroom and at Newswise.com .

The study paper in Nature Communications Earth & Environment is available .

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Marsico Lung Institute Publications for February 2025 /marsicolunginstitute/marsico-lung-institute-publications-for-february-2025/ Tue, 04 Mar 2025 14:59:01 +0000 /marsicolunginstitute/?p=6493 Marsico Lung Institute faculty, postdoc, student, and collaborator publications for February 2025 included papers appearing in Nature Materials, European Respiratory Journal, and Clinical Infectious Diseases. Check out the full list below: Wang ZJ, Li W, Li X, Nakajima T, Rubinstein M, Gong JP. Rapid self-strengthening in double-network hydrogels triggered by bond scission. Nat Mater. 2025 … Read more

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Marsico Lung Institute faculty, postdoc, student, and collaborator publications for February 2025 included papers appearing in Nature Materials, European Respiratory Journal, and Clinical Infectious Diseases. Check out the full list below:

  1. Wang ZJ, Li W, Li X, Nakajima T, Rubinstein M, Gong JP. . Nat Mater. 2025 Feb 26. doi: 10.1038/s41563-025-02137-6. Epub ahead of print. PMID: 40011594.
  2. Armaignac DL, Heavner SF, Rausen M, Zhang XT, Al-Hakim T, Strekalova YL, Shah N, Remy KE, Manion S, Haendel M, Kramer AA, Scruth EA, Rincon TA, Park S, Evans LE, Ozrazgat-Baslanti T, Herasevich V, Laudanski K, Murphy DJ, Engel HJ, Sikora A, Khanna AK, Zimmerman JJ, Reuter-Rice K, Cobb JP, Clermont G. . Crit Care Med. 2025 Feb 21. doi: 10.1097/CCM.0000000000006578. Epub ahead of print. PMID: 39982146.
  3. Dagher I, Kimple AJ, Ferkol TW, Sagel SD, Dell SD, Milla CE, Li L, Lin FC, Sullivan KM, Zariwala MA, Knowles MR, Rosenfeld M, Leigh MW, Davis SD; Genetic Disorders of Mucociliary Clearance Consortium. . OTO Open. 2025 Feb 21;9(1):e70079. doi: 10.1002/oto2.70079. PMID: 39989621; PMCID: PMC11843728.
  4. Saferali A, Wienecke AN, Xu Z, Liu T, Sheynkman GM, Hersh CP, Cho MH, Silverman EK, Zhou X, Wilson CL, Schnapp LM, Randell SH, Ramos SBV, Laederach A, Vollmers C, Castaldi PJ. . Eur Respir J. 2025 Feb 20:2401407. doi: 10.1183/13993003.01407-2024. Epub ahead of print. PMID: 39978861.
  5. Fazelpour F, Hill LC, Markovetz MR, Hill DB. . Annu Rev Anal Chem (Palo Alto Calif). 2025 Feb 14. doi: 10.1146/annurev-anchem-061622-015821. Epub ahead of print. PMID: 39952642.
  6. Shook JC, Genito CJ, Darwitz BP, Tyson KJ, Velez AZ, Bridwell SK, Parsons JB, Rowe SE, Marshall CW, Conlon BP, Thurlow LR. . Sci Adv. 2025 Feb 14;11(7):eads1591. doi: 10.1126/sciadv.ads1591. PMID: 39937900; PMCID: PMC11817934.
  7. Shapiro AJ, Wu EY, Morris-Rosendahl DJ, Olivier KN, Dell SD, Sagel SD, Dutmer CM, Mosquera RA, Rose M, O’Connor MG, Ma CA, Uzel G, Vece TJ, Zariwala MA, Knowles MR, Leigh MW, Davis SD, Ferkol TW. . J Pediatr. 2025 Feb 6:114499. doi: 10.1016/j.jpeds.2025.114499. Epub ahead of print. PMID: 39922272.
  8. Mandel H, Yoo YJ, Allen AJ, Abedian S, Verzani Z, Karlson EW, Kleinman LC, Mudumbi PC, Oliveira CR, Muszynski JA, Gross RS, Carton TW, Kim C, Taylor E, Park H, Divers J, Kelly JD, Arnold J, Geary CR, Zang C, Tantisira KG, Rhee KE, Koropsak M, Mohandas S, Vasey A, Mohammad Mosa AS, Haendel M, Chute CG, Murphy SN, O’Brien L, Szmuszkovicz J, Guthe N, Santana JL, De A, Bogie AL, Halabi KC, Mohanraj L, Kinser PA, Packard SE, Tuttle KR, Hirabayashi K, Kaushal R, Pfaff E, Weiner MG, Thorpe LE, Moffitt RA. . Clin Infect Dis. 2025 Feb 5:ciaf046. doi: 10.1093/cid/ciaf046. Epub ahead of print. PMID: 39907495.
  9. Dobson DA, Perryman A, McNell E, Kim HH, Porter NA, Rebuli ME, Jaspers I. . Am J Physiol Lung Cell Mol Physiol. 2025 Feb 1;328(2):L207-L214. doi: 10.1152/ajplung.00332.2024. PMID: 39716873.

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Schworer Receives AAAAI Foundation Faculty Development Award /marsicolunginstitute/schworer-receives-aaaai-foundation-faculty-development-award/ Thu, 27 Feb 2025 19:43:51 +0000 /marsicolunginstitute/?p=6475 Stephen Schworer, MD, PhD, Assistant Professor of Medicine in the Division of Rheumatology, Allergy, and Immunology, was recently awarded the American Academy of Allergy, Asthma & Immunology (AAAAI) Foundation Faculty Development Award for his project, “T2-skewed basal cells promote small airway mucus plugging in asthma.” Read the full story here.

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Stephen Schworer, MD, PhD, Assistant Professor of Medicine in the Division of Rheumatology, Allergy, and Immunology, was recently awarded the American Academy of Allergy, Asthma & Immunology (AAAAI) Foundation Faculty Development Award for his project, “T2-skewed basal cells promote small airway mucus plugging in asthma.”

Read the full story here.

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Conlon’s Research on Staphylococcus aureus Spotlighted in Various News Articles /marsicolunginstitute/conlons-research-on-staphylococcus-aureus-spotlighted-in-various-news-articles/ Mon, 24 Feb 2025 18:11:25 +0000 /marsicolunginstitute/?p=6471 Research led by Brian P. Conlon, PhD, has established a link between diabetes and antibiotic-resistant Staphylococcus aureus. This work has been spotlighted in various recent news articles, including: High Blood Glucose in Diabetes Promotes Rapid Development of Antibiotic-Resistant Staphylococcus Aureus (Pharmacy Times) Diabetes Linked to Antimicrobial Resistance, New Study Finds (Dailyhunt) Does Diabetes Drive Antibiotic … Read more

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Research led by Brian P. Conlon, PhD, has established a link between diabetes and antibiotic-resistant Staphylococcus aureus. This work has been spotlighted in various recent news articles, including:

(Pharmacy Times)

(Dailyhunt)

(LabRoots)

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Marsico Lung Institute Publications for January 2025 /marsicolunginstitute/marsico-lung-institute-publications-for-january-2025/ Fri, 14 Feb 2025 18:30:13 +0000 /marsicolunginstitute/?p=6467 Marsico Lung Institute faculty, postdoc, student, and collaborator publications for January 2025 included papers appearing in The Lancet: Respiratory Medicine, The American Journal of Respiratory and Critical Care Medicine, and Nucleic Acids Research. Check out the full list below: Farzal Z, Sullivan KM, Zariwala MA, Thorp BD, Senior BA, Ebert CS Jr, Davis S, Leigh … Read more

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Marsico Lung Institute faculty, postdoc, student, and collaborator publications for January 2025 included papers appearing in The Lancet: Respiratory Medicine, The American Journal of Respiratory and Critical Care Medicine, and Nucleic Acids Research. Check out the full list below:

  1. Farzal Z, Sullivan KM, Zariwala MA, Thorp BD, Senior BA, Ebert CS Jr, Davis S, Leigh MW, Knowles MR, Kimple AJ. . OTO Open. 2025 Jan 31;9(1):e70084. doi: 10.1002/oto2.70084. PMID: 39896853; PMCID: PMC11783683.
  2. Sims AC, Schäfer A, Okuda K, Leist SR, Kocher JF, Cockrell AS, Hawkins PE, Furusho M, Jensen KL, Kyle JE, Burnum-Johnson KE, Stratton KG, Lamar NC, Niccora CD, Weitz KK, Smith RD, Metz TO, Waters KM, Boucher RC, Montgomery SA, Baric RS, Sheahan TP. . mSphere. 2025 Jan 30:e0095124. doi: 10.1128/msphere.00951-24. Epub ahead of print. PMID: 39882872.
  3. Hickman E, Carberry V, Carberry C, Cooper B, Mordant AL, Mills A, Sokolsky M, Herring LE, Alexis NE, Rebuli ME, Jaspers I, Sheats K, Rager JE. . PLoS One. 2025 Jan 24;20(1):e0315743. doi: 10.1371/journal.pone.0315743. PMID: 39854355; PMCID: PMC11760557.
  4. Bayless R, Saini Y. Am J Respir Cell Mol Biol. 2025 Jan 21. doi: 10.1165/rcmb.2024-0575ED. Epub ahead of print. PMID: 39836037.
  5. Smyth TR, Brocke S, Kim YH, Christianson C, Kovalcik KD, Pancras JP, Hays MD, Wu W, An Z, Jaspers I. . Chem Res Toxicol. 2025 Jan 20;38(1):73-90. doi: 10.1021/acs.chemrestox.4c00291. PMID: 39704336.
  6. Bhatia A, Preiss AJ, Xiao X, Brannock MD, Alexander GC, Chew RF, Davis H, Fitzgerald M, Hill E, Kelly EP, Mehta HB, Madlock-Brown C, Wilkins KJ, Chute CG, Haendel M, Moffitt R, Pfaff ER; N3C Consortium. . PLoS Med. 2025 Jan 17;22(1):e1004493. doi: 10.1371/journal.pmed.1004493. PMID: 39823513. PMCID: PMC11790232
  7. Stevens EL, Chiel LE, Collins MS, Rama JA, Esther CR Jr, Richard K, Nelson BA, Weiss P, Nuncio B, Turner DA, Boyer D. . ATS Sch. 2025 Jan 15. doi: 10.34197/ats-scholar.2024-0105BR. Epub ahead of print. PMID: 39904503.
  8. DeMeis JD, Roberts JT, Delcher HA, Godang NL, Coley AB, Brown CL, Shaw MH, Naaz S, Dahal A, Alqudah SY, Nguyen KN, Nguyen AD, Paudel SS, Shell JE, Patil SS, Dang H, O’Neal WK, Knowles MR, Houserova D, Gillespie MN, Borchert GM. . Nucleic Acids Res. 2025 Jan 11;53(2):gkae1180. doi: 10.1093/nar/gkae1180. PMID: 39658038. PMCID: PMC11754661.
  9. Mwase C, Schworer SA, Gilmore RC, Khan F, Dy ABC, Haber AL, Boucher RC Jr, Randell SH, Mackman N, Park JA. . Am J Respir Cell Mol Biol. 2025 Jan 7. doi: 10.1165/rcmb.2024-0130OC. Epub ahead of print. PMID: 39773168.
  10. Faino AV, Gordon WW, Buckingham K, Stilp AM, Pace RG, Raraigh KS, Collaco JM, Zhou YH, Dang H, O’Neal W, Knowles MK, Cutting GR, Rosenfeld M, Bamshad MJ, Gibson RL, Blue EE; Cystic Fibrosis Genome Project. . Ann Am Thorac Soc. 2025 Jan 2. doi: 10.1513/AnnalsATS.202408-868OC. Epub ahead of print. PMID: 39746161.
  11. Goralski JL, Talati AN, Hardisty EE, Vora NL. . Obstet Gynecol. 2025 Jan 1;145(1):47-54. doi: 10.1097/AOG.0000000000005732. PMID: 39666984; PMCID: PMC11630662.
  12. Jain R, Goralski JL. . J Cyst Fibros. 2025 Jan;24(1):3-4. doi: 10.1016/j.jcf.2024.12.003. PMID: 39794183.
  13. Singh D, Brightling CE, Rabe KF, Han MK, Christenson SA, Drummond MB, Papi A, Pavord ID, Molfino NA, Almqvist G, Kotalik A, Hellqvist Å, Gołąbek M, Sindhwani NS, Ponnarambil SS; COURSE study investigators. . Lancet Respir Med. 2025 Jan;13(1):47-58. doi: 10.1016/S2213-2600(24)00324-2. PMID: 39653044.
  14. Soerianto W, Jaspers I. . Pediatr Pulmonol. 2025 Jan;60(1):e27448. doi: 10.1002/ppul.27448. PMID: 39714069.
  15. Despotes KA, Ceppe AS, Goralski JL, Donaldson SH. . Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251317200. doi: 10.1177/17534666251317200. PMID: 39891563; PMCID: PMC11786282.

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