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James S. Hagood, MD

Professor

Professor of Pediatrics, Division of Pulmonology, ºÚÁÏÍø
Director, Program for Rare and Interstitial Lung Disease, Children’s Research Institute and Marsico Lung Institute

Research Focus:

In the laboratory, we study the regulation of fibroblast phenotype in the context of pulmonary fibrosis and lung development. The current principal interests of my lab are: regulation of expression of Thy-1, a fibrosis suppressor, by transcriptional silencing and vesicular shedding; roles and regulation of fibroblast differentiation in lung alveolar development; epigenomic alterations in lung development and fibrogenesis; targeted delivery of antifibrotic therapies to the fibrotic lung; the roles of extracellular vesicles in lung fibrosis progression and resolution; and mechanisms of Thy-1 signaling regulating myofibroblastic adhesion, migration, differentiation and survival.

External Links:

Selected Recent Publications:

  1. Song Q, Singh A, McDonough JE, Adams TS, Vos R, De Man R, Myers G, Ceulemans LJ, Vanaudenaerde BM, Wuyts WA, Yan X, Schupp J, Hagood JS, Kaminski N, Bar-Joseph Z. . PLoS Comput Biol. 2024 Dec 19;20(12):e1012632. doi: 10.1371/journal.pcbi.1012632. PMID: 39700255; PMCID: PMC11741621.
  2. Hagood JS. . Am J Respir Cell Mol Biol. 2024 Nov 20. doi: 10.1165/rcmb.2024-0524ED. Epub ahead of print. PMID: 39565183.
  3. Li R, Sone N, Gotoh S, Sun X, Hagood JS. . Pediatr Pulmonol. 2024 Sep;59(9):2349-2359. doi: 10.1002/ppul.26490. PMID: 37204232.
  4. Nevel RJ, Deutsch GH, Craven D, Deterding R, Fishman MP, Wambach JA, Casey A, Krone K, Liptzin DR, O’Connor MG, Kurland G, Taylor JB, Gower WA, Hagood JS, Conrad C, Tam-Williams JB, Fiorino EK, Goldfarb S, Sadreameli SC, Nogee LM, Montgomery G, Hamvas A, Laguna TA, Bansal M, Lew C, Santiago M, Popova A, De A, Chan M, Powers MR, Josephson MB, Camburn D, Voss L, Li Y, Young LR; chILD Registry Collaborative. . Pediatr Pulmonol. 2024 Sep;59(9):2236-2246. doi: 10.1002/ppul.26568. PMID: 37401889. PMCID: PMC10764638.
  5. Jain S, Pei L, Spraggins JM, Angelo M, Carson JP, Gehlenborg N, Ginty F, Gonçalves JP, Hagood JS, Hickey JW, Kelleher NL, Laurent LC, Lin S, Lin Y, Liu H, Naba A, Nakayasu ES, Qian WJ, Radtke A, Robson P, Stockwell BR, Van de Plas R, Vlachos IS, Zhou M; HuBMAP Consortium; Börner K, Snyder MP. . Nat Cell Biol. 2023 Aug;25(8):1089-1100. doi: 10.1038/s41556-023-01194-w. PMID: 37468756. PMCID: PMC10681365.
  6. McKinzie CJ, Gower WA, Hagood JS, Vece TJ. . Pediatr Pulmonol. 2023 Aug;58(8):2396-2398. doi: 10.1002/ppul.26465. PMID: 37161910.
  7. Gutierrez MJ, Nino G, Sun D, Restrepo-Gualteros S, Sadreameli SC, Fiorino EK, Wu E, Vece T, Hagood JS, Maglione PJ, Kurland G, Koumbourlis A, Sullivan KE. . J Allergy Clin Immunol. 2022 Dec;150(6):1314-1324. doi: 10.1016/j.jaci.2022.08.024. PMID: 36244852. PMCID: PMC9826631.
  8. Vece TJ, Gower WA, Davis SD, Austin A, McKinzie CJ, Hatch JE, Davis M, Hagood JS. . Pediatr Pulmonol. 2022 Nov;57(11):2583-2588. doi: 10.1002/ppul.26083. PMID: 35932221.
  9. Dinnon KH§, Leist SR§, Okuda K§, Dang H§, Fritch EJ§, Gully KL, De la Cruz G, Evangelista MD, Asakura T, Gilmore RC, Hawkins P, Nakano S, West A, Schäfer A, Gralinski LE, Everman JL, Sajuthi SP, Zweigart MR, Dong S, McBride J, Cooley MR, Hines JB, Love MK, Groshong SD, VanSchoiack A, Phelan SJ, Liang Y, Hether T, Leon M, Zumwalt RE, Barton LM, Duval EJ, Mukhopadhyay S, Stroberg E, Borczuk A, Thorne LB, Sakthivel MK, Lee YZ, Hagood JS, Mock JR, Seibold MA, O’Neal WK, Montgomery SA, Boucher RC*, Baric RS*. . Sci Transl Med. 2022 Sep 28;14(664):eabo5070. doi: 10.1126/scitranslmed.abo5070. PMID: 35857635. PMCID: PMC9273046. §These authors contributed equally. *Joint senior authorship.
  10. Hu P, Leyton L, Hagood JS, Barker TH. . Front Cell Dev Biol. 2022 Jun 6;10:928510. doi: 10.3389/fcell.2022.928510. PMID: 35733855; PMCID: PMC9208718.
  11. McKinzie CJ, Hagood JS, Fiorino EK, Fishman MP, Nevel RJ, Gower WA, Vece TJ. . Pediatr Pulmonol. 2022 Jun;57(6):1535-1536. doi: 10.1002/ppul.25883. PMID: 35246971.
  12. Jackson WM, Santos HP Jr, Hartwell HJ, Gower WA, Chhabra D, Hagood JS, Laughon MM, Payton A, Smeester L, Roell K, O’Shea TM, Fry RC. . Pediatr Res. 2022 May;91(6):1428-1435. doi: 10.1038/s41390-021-01868-x. PMID: 34857876. PMCID: PMC9160210.
  13. Duong TE, Wu Y, Sos BC, Dong W, Limaye S, Rivier LH, Myers G, Hagood JS, Zhang K. . Cell Genom. 2022 Mar 9;2(3):100108. doi: 10.1016/j.xgen.2022.100108. PMID: 35434692; PMCID: PMC9012447.
  14. Bradford L, Ross MK, Minso J, Cernelc-Kohan M, Shayan K, Wong SS, Li X, Rivier L, Jegga AG, Deutsch GH, Vece TJ, Loughlin CE, Gower WA, Hurley C, Furman W, Stokes D, Hagood JS. . Pediatr Pulmonol. 2022 Jan;57(1):264-272. doi: 10.1002/ppul.25709. PMID: 34585851.
  15. Martin M, Zhang J, Miao Y, He M, Kang J, Huang HY, Chou CH, Huang TS, Hong HC, Su SH, Wong SS, Harper RL, Wang L, Bhattacharjee R, Huang HD, Chen ZB, Malhotra A, Rabinovitch M, Hagood JS, Shyy JY. . JCI Insight. 2021 Nov 22;6(22):e125635. doi: 10.1172/jci.insight.125635. PMID: 34806652. PMCID: PMC8663776.
  16. Li X, Wong SS, Tan C, Espinoza CR, Hagood JS.. Minerva Med. 2021 Oct;112(5):622-630. doi: 10.23736/S0026-4806.20.06691-4. PMID: 32696636.
  17. Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. . Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101270118. doi: 10.1073/pnas.2101270118. PMID: 34253615. PMCID: PMC8307749.
  18. Tamburro RF, Cooke KR, Davies SM, Goldfarb S, Hagood JS, Srinivasan A, Steiner ME, Stokes D, DiFronzo N, El-Kassar N, Shelburne N, Natarajan A; Pulmonary Complications of Pediatric Hematopoietic Stem Cell Transplantation Workshop Participants. . Ann Am Thorac Soc. 2021 Mar;18(3):381-394. doi: 10.1513/AnnalsATS.202001-006OT. PMID: 33058742. PMCID: PMC7919149.
  19. Maldonado H, Hagood JS. . J Mol Med (Berl). 2021 Feb;99(2):213-224. doi: 10.1007/s00109-020-02026-2. PMID: 33392631.
  20. Vece TJ, Wambach JA, Hagood JS. . Pediatr Pulmonol. 2020 Jul;55(7):1828-1837. doi: 10.1002/ppul.24809. PMID: 32533908.
  21. Gower WA, Hagood JS. . Pediatr Pulmonol. 2020 Jun;55(6):1303-1304. doi: 10.1002/ppul.24797. PMID: 32364314.
  22. Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR. . Ann Am Thorac Soc. 2020 Jun;17(6):724-72. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152. PMCID: PMC7258416.
  23. Worthington EN, Hagood JS. . Int J Mol Sci. 2020 Mar 27;21(7). doi: 10.3390/ijms21072318. PMID: 32230828. PMCID: PMC7177288.
  24. Zemans RL, Hagood JS. . Nat Immunol. 2020 Feb;21(2):112-114. doi: 10.1038/s41590-019-0585-9. PMID: 31959978.
  25. Ding J, Ahangari F, Espinoza CR, Chhabra D, Nicola T, Yan X, Lal CV, Hagood JS, Kaminski N, Bar-Joseph Z, Ambalavanan N. . Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L556-L568. doi: 10.1152/ajplung.00554.2018. PMID: 31432713; PMCID: PMC6879899.
  26. Tan C, Jiang M, Wong SS, Espinoza CR, Kim C, Li X, Connors E, Hagood JS. . JCI Insight. 2019 Nov 1;4(21). doi: 10.1172/jci.insight.131152. PMID: 31672942. PMCID: PMC6948761.
  27. Negreros M, Hagood JS, Espinoza CR, Balderas-Martínez YI, Selman M, Pardo A. . PLoS One. 2019 Oct 11;14(10):e0223512. doi: 10.1371/journal.pone.0223512. PMID: 31603936; PMCID: PMC6788707.
  28. Hagood JS. . Front Cell Dev Biol. 2019 Feb 25;7:26. doi: 10.3389/fcell.2019.00026. PMID: 30859102; PMCID: PMC6397883.
  29. Shentu TP, Hagood JS. . Am J Respir Cell Mol Biol. 2019 Mar;60(3):251-252. doi: 10.1165/rcmb.2018-0345ED. PMID: 30372117.
  30. Fiore VF, Wong SS, Tran C, Tan C, Xu W, Sulchek T, White ES, Hagood JS, Barker TH. . JCI Insight. 2018 Oct 18;3(20). doi: 10.1172/jci.insight.97597. PMID: 30333317; PMCID: PMC6237458.
  31. Duong TE, Hagood JS. . Curr Pathobiol Rep. 2018 Mar;6(1):79-96. doi: 10.1007/s40139-018-0155-0. PMID: 30271681; PMCID: PMC6159951.
  32. Ding J, Hagood JS, Ambalavanan N, Kaminski N, Bar-Joseph Z.. PLoS Comput Biol. 2018 Mar 14;14(3):e1006019. doi: 10.1371/journal.pcbi.1006019. PMID: 29538379; PMCID: PMC5868853.
  33. Shentu TP, Huang TS, Cernelc-Kohan M, Chan J, Wong SS, Espinoza CR, Tan C, Gramaglia I, van der Heyde H, Chien S, Hagood JS. . Sci Rep. 2017 Dec 22;7(1):18052. doi: 10.1038/s41598-017-18288-9. PMID: 29273797; PMCID: PMC5741716.
  34. Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood JS, Durden DL. . PLoS One. 2017 Aug 17;12(8):e0182851. doi: 10.1371/journal.pone.0182851. PMID: 28817691; PMCID: PMC5560537.
  35. Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood JS. . Lab Invest. 2017 Mar;97(3):256-267. doi: 10.1038/labinvest.2016.145. PMID: 28165468; PMCID: PMC5663248.
  36. Kleyman M, Sefer E, Nicola T, Espinoza C, Chhabra D, Hagood JS, Kaminski N, Ambalavanan N, Bar-Joseph Z. . Elife. 2017 Jan 26;6. doi: 10.7554/eLife.18541. PMID: 28124972; PMCID: PMC5319842.
  37. Glasser SW, Hagood JS, Wong S, Taype CA, Madala SK, Hardie WD. . Am J Pathol. 2016 May;186(5):1066-77. doi: 10.1016/j.ajpath.2016.01.018. Review. PMID: 27021937; PMCID: PMC4861766.
  38. Checa M, Hagood JS, Velazquez-Cruz R, Ruiz V, García-De-Alba C, Rangel-Escareño C, Urrea F, Becerril C, Montaño M, García-Trejo S, Cisneros Lira  J, Aquino-Gálvez A, Pardo A, Selman M. . PLoS One. 2016 Mar 2;11(3):e0150383. doi: 10.1371/journal.pone.0150383. PMID: 26934369; PMCID: PMC4775036.
  39. Fiore VF, Strane PW, Bryksin AV, White ES, Hagood JS, Barker TH. . J Cell Biol. 2015 Oct 12;211(1):173-90. doi: 10.1083/jcb.201505007. PMID: 26459603; PMCID: PMC4602038.
  40. Fan LL, Dishop MK, Galambos C, Askin FB, White FV, Langston C, Liptzin DR, Kroehl ME, Deutsch GH, Young LR, Kurland G, Hagood J, Dell S, Trapnell BC, Deterding RR; Children’s Interstitial and Diffuse Lung Disease Research Network (chILDRN). . Ann Am Thorac Soc. 2015 Oct;12(10):1498-505. doi: 10.1513/AnnalsATS.201501-064OC. PMID: 26291470; PMCID: PMC4627419.
  41. Leyton L, Hagood JS. . Adv Neurobiol. 2014;8:3-20. Review. PMID: 25300130.
  42. Sanders YY, Hagood JS, Liu H, Zhang W, Ambalavanan N, Thannickal VJ. . Eur Respir J. 2014 May;43(5):1448-58. doi: 10.1183/09031936.00095113. PMID: 24603818.
  43. Harris WT, Kelly DR, Zhou Y, Wang D, MacEwen M, Hagood JS, Clancy JP, Ambalavanan N, Sorscher EJ. . PLoS One. 2013 Aug 12;8(8):e70196. doi: 10.1371/journal.pone.0070196. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/d0132de3-56ca-4258-9119-bdab0ceb2cff. Macewen, Mark [corrected to MacEwen, Mark]. PMID: 23950911; PMCID: PMC3741283.
  44. Kurland G, Deterding RR, Hagood JS, Young LR, Brody AS, Castile RG, Dell S, Fan LL, Hamvas A, Hilman BC, Langston C, Nogee LM, Redding GJ; American Thoracic Society Committee on Childhood Interstitial Lung Disease (chILD) and the chILD Research Network. . Am J Respir Crit Care Med. 2013 Aug 1;188(3):376-94. doi: 10.1164/rccm.201305-0923ST. Review. PMID: 23905526; PMCID: PMC3778735.
  45. Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood JS. . Pediatr Pulmonol. 2014 Apr;49(4):400-9. doi: 10.1002/ppul.22805. PMID: 23798474; PMCID: PMC4145861.
  46. Bradley JE, Chan JM, Hagood JS. . Lab Invest. 2013 Mar;93(3):365-74. doi: 10.1038/labinvest.2012.178. PMID: 23358110; PMCID: PMC5662197.

For further publications, please see .

Headshot of James Hagood