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The Marsico Lung Institute (MLI)/黑料网 Cystic Fibrosis Center (CF Center) has a rich tradition of collaboration. It exhibits a wide scope but 鈥渢hin鈥� coverage of the scientific areas relevant to CF. In brief, we typically have recruited only one or two experts in a given field, but have attempted to use our large numbers of investigators to cover a wide spectrum of scientific disciplines required to tackle CF research in a collaborative and efficient fashion.

There are many key areas of CF research that require such collaborative interactions (see Table 1). The Hooker 黑料网 Proteomics gift ($25 M) has spurred an extra CF Center collaborative effort at 黑料网, termed the . The VLP has allowed us to bring a unique group of physicists, applied mathematicians, and physical chemists into the world of CF research. One measure of the outcome of the collaborative efforts at 黑料网 is the large number of multi-authored publications that can be observed in the overall 黑料网 bibliography. Another measure of our collaborative efforts is the number of NIH multi investigator grants awarded to the 黑料网 CF Center, including a Program Project based in the CF Center [Pulmonary Epithelia in Health and Disease (HL34322)], a PPG shared between the 黑料网 MLI and the Gene Therapy Center [Gene Therapy of Airways and Hematopoietic Diseases (HL51818, HL66973)], a Molecular Therapeutics Translational Core Grant (DK65988), a multi-investigator systems biology grant for the Virtual Lung Group (HL077546), collaborative R01s on gene modifiers between 黑料网 and Case Western (HL68890) and 黑料网 and Columbia University (DK66368), and on CFTR biogenesis between 黑料网 and Scripps (DK051870), and, finally, a SCCOR focused on comparing host defense in CF vs. COPD subjects (HL084934).

An important facilitator of CF translational research at 黑料网 is the Clinical and Translational Science Award. The CTSA provides not only the clinical translational facilities for CF translational research at 黑料网, but also >$2,000,000/year in Pilot Grant and Core Facility support. The CF Center Director is one of four co-PIs for the 黑料网 CTSA.

In sum, collaborative efforts are certainly not unique to the 黑料网 CF Center. However, we believe the 黑料网 CF Center has recruited an extraordinarily broad scope of talented basic scientists from all basic science departments with research interests consistently focused on CF, who interrelate seamlessly with high-quality clinical translational researchers from both the and .

Director: Richard C. Boucher, MD

Co-Director: Michael R. Knowles, MD

Internal Advisory Board: T Magnuson, RJ Samulski