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Kale Hartmann (Jeff Sekelsky lab) published an article titled “Centromere-proximal meiotic crossovers in Drosophila melanogaster are suppressed by both highly repetitive heterochromatin and proximity to the centromere” in Genetics (DOI: 10.1534/genetics.119.302509).The article was chosen for Highlights by the editors.聽 Image:Relationship of genome features (gene and TE density) to crossover density...

David Lee (Mauro Calabrese lab) published a paper titled “A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin“ in Nucleic Acids Research (DOI:10.1093/nar/gkz432). GMB students Rachel Cherney and Megan Schertzer are co-authors. Image: The TETRIS reporter demonstrates that Xist-2kb represses luciferase at the post-transcriptional level;...

Claire Trincot (Kathleen Caron lab) published a paper titled “Adrenomedullin induces cardiac lymphangiogenesis after myocardial infarction and regulates cardiac edema via connexin 43“ in Circulation Research (DOI:10.1161/CIRCRESAHA.118.313835). Image: Immunohistochemistry of cardiac sections in infarcted adult Adm+/+ and Admhi/hi mice; see article for details. See also the commentary on this article:...

Kale Hartmann and Talia Hatkevich (Jeff Sekelsky lab) published an article titled “Meiotic MCM proteins promote and inhibit crossovers during meiotic recombination.” in Genetics (DOI: 10.1534/genetics.119.302221). Image:Schematic of meiotic MCM protein structures; see article for details. Please see our page on Publications by GMB Students for more.

Katie Headley (Nate Hathaway lab) published a paper titled “Chemical screen for epigenetic barriers to single allele activation of Oct4“ in Stem Cell Research (DOI: 10.1016/j.scr.2019.101470). Image: Results of a small molecule screen for chemical facilitators of CiA:Oct4 activation; see article for details. Please see our page on Publications by...

Salma Azam (Chad Pecot lab) published an article titled “Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis” in Oncogene. (DOI: 10.1038/s41388-019-0786-6)聽 Image:Perturbation of the Quaking/miR-200 pathway inhibits endothelial sprouting; click to enlarge; see article for details. Please see our page on Publications...

Chris Uyehara (Dan McKay lab) published a paper titled “Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila” in Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.1900343116). Image: Expression of the broad gene without and with expression of an ecdysone receptor;...

Casey Schmidt (Greg Matera lab) published an article titled “Molecular determinants of metazoan tricRNA biogenesis” in Nucleic Acids Research. (DOI: 110.1093/nar/gkz311)聽 Image: tRNA splicing pathways; click to enlarge; see article for details. Please see our page on Publications by GMB Students for more.

Tim Dinh (Praveen Sethupathy lab) published an article titled “MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma” in Cellular and Molecular Gastroenterology and Hepatology. Image: miR-375 is a candidate master regulator of cancer pathways in FLC; click to enlarge; see article for details.) Please see our page on Publications...

Kristi Schaefer (recent graduate of Mark Peifer lab) published a review article titled “Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates” in Developmental Cell (DOI:10.1016/j.devcell.2019.01.025). Image: textbook model of Wnt signalling; click to enlarge; see article for details.) Please see our page on Publications by GMB Students for more.

Robin Armstrong and Taylor Penke (Bob Duronio lab) published a paper titled “Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila“ in Genome Research (DOI: 10.1101/gr.239913.118). Image: Replication timing in a 5 Mb region of pericentric heterochromatin in wild-type and Histone H3K9R mutants; see article...

Matt Tegowski (Al Baldwin lab) published a paper titled “Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2s“ in Journal of Biological Chemistry (DOI: 10.1074/jbc.RA118.003719). Image: Model describing mechanism of thioridazine effects on triple-negative breast cancer cell lines; see article...