黑料网

Noor Singh (Kacy Gordon Lab) published an article聽titled “The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during C.聽elegans聽gonad organogenesis” in Current Biology showing how a highly conserved small GTPase can prevent cell fragmentation during leader cell migration in C. elegans gonad morphogenesis.      

Rachel Dumez-Kornegay & Rob Dowen: Probiotics in kombucha found to mimic fasting and reduce fat stores in C. elegans model   鈥淭hese findings are significant as they are consistent with purported human health benefits of kombucha tea, which include protection against metabolic diseases, improved liver function, and reduced fat accumulation.鈥澛犫��...

Marielle Bond (Doug Phanstiel and Hyejung Won labs) published an article titled 鈥淐hromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features鈥� in Genome Research (doi:10.1101/gr.277397.122). M.L. Bond, E.S. Davis, I.Y. Quiroga, A. Dey, M. Kiran, M.I. Love, H. Won, and D.H. Phanstiel...

Emma Hinkle (Jimena Giudice lab) published an article titled “Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins” in Communications Biology (DOI: 10.1038/s42003-022-03915-7). Image: Cartoon of how mechanosensitive targets might play a role in the MAPK signaling cascade (see article for details; click to enlarge). Please...

Gabby Gentile聽(Jimena Giudice lab) published an article titled “The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis” in FASEB Journal (DOI: 10.1096/fj.202101627RR). GMB students Hannah Wiedner and Emma Hinkle are co-authors. Image: Reduced expression of the muscle differentiation marker MYH3 after siRNA knockdown of SNAP23 (see article for details;...

Elizabeth Abrash (Mauro Calabrese lab) wrote a Preview piece titled “Oncogenic transcription factors and neogenes: New opportunities for cancer immunotherapy?” published in Molecular Cell (DOI: 10.1016/j.molcel.2022.06.006). Image: Outline of the neogene approach, with future directions and challenges(see article for details; click to enlarge). Please see our page on Publications by...

Emma Hinkle and Hannah Wiedner (Jimena Giudice lab) published an article titled “Alternative splicing regulation of membrane trafficking genes during myogenesis” in RNA (DOI: 10.1261/rna.078993.121). GMB student Gabrielle Gentile is a co-author. Image: Predicted motifs regulating alternative splicing of membrane trafficking genes.(see article for details; click to enlarge). Please see...

Emma Hinkle and Hannah Wiedner (Jimena Giudice lab) published an article titled “Alternative splicing regulation of membrane trafficking genes during myogenesis” in RNA (DOI: 10.1261/rna.078993.121). GMB student Gabrielle Gentile is a co-author. Image: Predicted motifs regulating alternative splicing of membrane trafficking genes.(see article for details; click to enlarge). Please see...

Kia Perez-Vale (Mark Peifer lab) published an article titled “Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis” in Journal of Cell Biology (DOI:10.1083/jcb.202104087). Image: Mesoderm invagination defects in canoe mutants聽(click to enlarge; see article for details).   Please see Publications by GMB Students page for more.

Nate Diehl聽(Channing Der lab) published an article titled “The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer” in Journal of Biological Chemistry聽(DOI:10.1016/j.jbc.2021.101335). . Image: Inhibition of WEE1 + ERK1/2 arrests growth of PDAC organoids (see article for details; click to enlarge). Please...

Jack Sanford聽(Yanping Zhang lab) published an article titled “MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail” in BMC Molecular and Cell Biology (DOI:10.1186/s12860-021-00385-3). Image: Protein blots showing that DNA damage inhibits MDMX suppression of p53 protein expression聽(see article for...

Spencer Nystrom聽(Dan McKay lab) published an article titled “Memes: A motif analysis environment in R using tools from the MEME Suite” in PLOS Computational Biology (DOI: 10.1371/journal.pcbi.1008991). Image: Representative plots generated by Memes. (see article for details; click to enlarge). Please see our page on Publications by GMB Students for...