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Congratulations to Matt Niederhuber (Dan McKay lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.聽 Matt’s project is titled, “Temporal Control of Enhancer Decommissioning.” Please also see our page on Grants to GMB Students.

Michelle Hoffner (Shehzad Sheikh lab) and Dean Nehama (Barbara Savoldo lab) were inducted into the Frank Porter Graham Graduate and Professional Student Honor Society. This award recognizes “outstanding service provided to the University and community by graduate and professional students.” Please also see our page on Awards to GMB Students.

Kelsey Gray (Greg Matera lab) published a paper titled “Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron“ in Molecular Biology of the Cell (DOI: 10.1091/mbc.E17-11-0627). Image: Proposed model of SMN as a substrate of SCFSlmb E3 ubiquitin ligase; see article for details. Please see...

Blake Albright (Aravind Asokan lab) published an article titled “Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier” in Molecular Therapy (DOI: 10.1016/j.ymthe.2017.10.017). Image: Mapping a minimal AAVrh.10 footprint for crossing the blood-brain barrier; see article for details.   Please see our page on Publications by GMB...

Morgan Brady (Jeff Sekelsky lab) published an article titled “Loss of Drosophila Mei-41/ATR Alters Meiotic Crossover Patterning” in Genetics (DOI: 10.1534/genetics.117.300634). Image: Changes in crossover interference in ATR mutants; see article for details. Please see our page on Publications by GMB Students for more.

Tamara Roman (Karen Mohlke lab) published a review titled “Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease” in Current Opinion in Genetics and Development聽(DOI: 10.1016/j.gde.2018.02.004). Image: Chromatin regulatory annotations predict rs10872142 is located within an enhancer; see article for details....

Luke Laudermilk (Samir Kelada lab) published a paper titled “Differential regulation of Zfp30 expression in murine airway epithelia through altered binding of ZFP148 to rs51434084” in G3: Genes|Genomes|Genetics (DOI: 10.1534/g3.117.300507). Image: Differential ZFP148 binding demonstrated by electrophoretic mobility supershift assay super-shifting (click to enlarge); see article for details. Please see...

Adele Musicant (Tony Amelio lab) was awarded an NRSA F31 fellowship from the National Institute of Dental and Craniofacial Research. Adele’s project is titled, “The Role of CRTC1/MAML2-Mediated Interactions with CREB and MYC in Defining the Cellular Heterogeneity of Salivary Tumors. Please also see our page on Grants to GMB...

Katy Koreski (Bob Duronio lab) published a paper titled “Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP“ in Genes and Development (DOI: 10.1101/gad.300855.117). Image (click to enlarge): Polytene chromosomes from Drosophila virilis showing localization of CLAMP and Gaga factor (see article for details). Please see our page...

Mike Conlin (Dale Ramsden lab) published a paper titled “DNA ligase IV guides end-processing xhoice during nonhomologous end joining” in Cell Reports (DOI: 10.1016/j.celrep.2017.08.091). Image: Alignment of DNA Ligase IV to Lig I crystal structure, showing Lig IV region deleted by CRISPR/Cas9 (see article for details). Please see our page...

Taylor Penke (Bob Duronio lab) published a paper titled “Functional redundancy of variant and canonical histone H3 lysine 9 modification in Drosophila“ in Genetics (DOI: 10.1534/genetics.117.300480). Image: Heterochromatin marks in polytene chromosomes from wild-type and Histone H3.3 mutants (null and K9R missense (see article for details). Please see our page...

Charlie Hodgens (Joe Keiber lab) published a paper titled “indCAPS: A tool for designing screening primers for CRISPR/Cas9 mutagenesis events” in PLOS One (DOI: 10.1371/journal.pone.0188406). Image: A. thaliana seedlings imaged at 2.5 weeks of growth, showing phenotypes of CRISPR mutations in the cytokine gene AHK3 designed using the indCAPS tool....