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Pedro Pozo (Jean Cook lab) published an聽 review article titled, “Cdt1 variants reveal unanticipated aspects of interactions with Cyclin/CDK and MCM important for normal genome replication” in Molcular Biology of the Cell (DOI: 10.1091/mbc.E18-04-0242).聽 Image: Flow cytometry profiles of cells with Ctd1 mutations; see paper for details.   Please see...

Robin Armstrong and Taylor Penke (Bob Duronio lab) published a paper titled “Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila“ in Genome Research (DOI: 10.1101/gr.239913.118). Image: Replication timing in a 5 Mb region of pericentric heterochromatin in wild-type and Histone H3K9R mutants; see article...

Rowan Beck (Praveen Sethupathy and Mirek Styblo labs) published an article titled, “Circulating miRNAs Associated with Arsenic Exposure” in Environmental Science and Technology (DOI: 10.1021/acs.est.8b06457).聽 Image: Outline of experimental strategy. See paper for details.   Please see our page on Publications by GMB Students for more.

Matt Tegowski (Al Baldwin lab) published a paper titled “Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2s“ in Journal of Biological Chemistry (DOI: 10.1074/jbc.RA118.003719). Image: Model describing mechanism of thioridazine effects on triple-negative breast cancer cell lines; see article...

Lauren Donoghue (Samir Kelada lab) received the Jo Rae Wright Young Investigator of the Year Award at the FASEB Lung Epithelium in Health and Disease聽conference.聽This award is聽given to one trainee in recognition of outstanding work described in an oral presentation. Lauren’s presentation was entitled “Genetic Analysis of Secreted Airway Mucins...

Carrie Wilczewski (Frank Conlon lab) published a paper titled “CHD4 and the NuRD complex directly control cardiac sarcomere formation“ in Proceedings of the National Academy of Sciences of the USA (DOI: 10.1073/pnas.1722219115). Image: Scanning electron micrographs of Chd4螖flox/螖flox and control hearts; see article for details. Please see our page on...

Anna Chiarella (Nate Hathaway lab) published a paper titled “Cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications“ in Biochemistry (DOI: 10.1021/acs.biochem.8b00075). Image: 16-fold increase in efficiency of sonication when nanodroplets are used; see article for details. Please see our page on...

Ricky Antonia (Al Baldwin lab) published a paper titled “IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells“ in Science Signaling (DOI: 10.1126/scisignal.aan5850). Image: IKK regulates basal AMPK Thr172 phosphorylation in cell lines; see article for details. Please see our page on Publications by...

Lauren Donoghue (Samir Kelada lab) was awarded an NRSA F31 fellowship from the National Heart, Lung, and Blood Institute.Lauren’s project is titled, “Genetic and Longitudinal Analysis of Airway Remodeling.” Please also see our page on Grants to GMB Students.

Kristi Schaefer (Mark Peifer lab) published an article titled “Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo” in PLOS Genetics (DOI:10.1371/journal.pgen.1007339). Image: Accumulation of Arm, axin, and Wg in聽Drosophila embryos; click to enlarge; see article for...

Congratulations to Nicole Arruda (Jill Dowen lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.聽 Nicole’s project is titled, “Cis-Regulatory Elements Connect Gene Expression and Genome Organization.” Please also see our page on Grants to GMB Students.

Congratulations to Allyson Roberts (Bob Goldstein lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.聽 Allyson’s project is titled, “Investigating the relationship between cell fate specification and shape change during development.” Please also see our page on Grants to GMB Students.