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Congratulations to Jeanne-Marie McPherson (Bob Duronio聽and Dan McKay聽labs), who was awarded an NRSA F31 predoctoral fellowship from the National Institute on Aging of the National Institutes of Health. Jeanne-Marie’s project is titled “Interrogating the roles of canonical versus variant histone H3 in genome function during aging.”     Please also...

Emma Hinkle (Jimena Giudice lab) published an article titled “Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins” in Communications Biology (DOI: 10.1038/s42003-022-03915-7). Image: Cartoon of how mechanosensitive targets might play a role in the MAPK signaling cascade (see article for details; click to enlarge). Please...

Winners of awards at the Genetics Retreat were: Best Talk: Alex Stutzman (Jill Dowen and Dan McKay labs) Best Talk: Rachel DuMez (Rob Dowen聽lab) Best Poster: Sonja Mikhailovic (Jeremy Purvis and Adriana Beltran labs)

Sarah Brotman (Karen Mohlke lab) and Hannah Wiedner (Jimena Giudice lab) were selected as winners of the Terry Magnuson Dissertation Award. This award, named in honor of the founding chair of the Department of Genetics at 黑料网, is given to one or two outstanding students in their final year of...

Congratulations to Nila Pazhayam (Jeff Sekelsky lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institute on Aging of the National Institutes of Health.聽 Nila’s project is titled “Preventing Age-Associated Oocyte Aneuploidy: Mechanisms Behind the Drosophila melanogaster Centromere Effect.”   Please also see our page on Grants...

GMB students Sarah Brotman (Karen Mohlke lab) and Nisitha Sengottuvel (Chad Pecot lab) participated in the Shadow a Scientist program. Shadow A Scientist is a graduate-student run organization that plans and conducts outreach visits for underserved communities in NC. Sarah and Saygin participated in a Q&A session with students from...

Gabby Gentile聽(Jimena Giudice lab) published an article titled “The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis” in FASEB Journal (DOI: 10.1096/fj.202101627RR). GMB students Hannah Wiedner and Emma Hinkle are co-authors. Image: Reduced expression of the muscle differentiation marker MYH3 after siRNA knockdown of SNAP23 (see article for details;...

Elizabeth Abrash (Mauro Calabrese lab) wrote a Preview piece titled “Oncogenic transcription factors and neogenes: New opportunities for cancer immunotherapy?” published in Molecular Cell (DOI: 10.1016/j.molcel.2022.06.006). Image: Outline of the neogene approach, with future directions and challenges(see article for details; click to enlarge). Please see our page on Publications by...

Emma Hinkle and Hannah Wiedner (Jimena Giudice lab) published an article titled “Alternative splicing regulation of membrane trafficking genes during myogenesis” in RNA (DOI: 10.1261/rna.078993.121). GMB student Gabrielle Gentile is a co-author. Image: Predicted motifs regulating alternative splicing of membrane trafficking genes.(see article for details; click to enlarge). Please see...

Kia Perez-Vale (Mark Peifer lab) published an article titled “Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis” in Journal of Cell Biology (DOI:10.1083/jcb.202104087). Image: Mesoderm invagination defects in canoe mutants聽(click to enlarge; see article for details).   Please see Publications by GMB Students page for more.

Nate Diehl聽(Channing Der lab) published an article titled “The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer” in Journal of Biological Chemistry聽(DOI:10.1016/j.jbc.2021.101335). . Image: Inhibition of WEE1 + ERK1/2 arrests growth of PDAC organoids (see article for details; click to enlarge). Please...

Jack Sanford聽(Yanping Zhang lab) published an article titled “MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail” in BMC Molecular and Cell Biology (DOI:10.1186/s12860-021-00385-3). Image: Protein blots showing that DNA damage inhibits MDMX suppression of p53 protein expression聽(see article for...