{"id":12522,"date":"2023-04-14T08:26:25","date_gmt":"2023-04-14T12:26:25","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=12522"},"modified":"2023-04-14T08:27:17","modified_gmt":"2023-04-14T12:27:17","slug":"hyejung-won-phd-receives-simons-foundation-award","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/hyejung-won-phd-receives-simons-foundation-award\/","title":{"rendered":"Hyejung Won, PhD Receives Simons Foundation Award"},"content":{"rendered":"<figure id=\"attachment_6212\" class=\"thumbnail wp-caption alignright\" style=\"width: 260px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6212 \" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/08\/hyejung-won.jpg\" alt=\"Hyejung Won\" width=\"250\" height=\"333\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/08\/hyejung-won.jpg 188w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/08\/hyejung-won-150x199.jpg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><figcaption class=\"caption wp-caption-text\">Dr. Hyejung Won (Assistant Professor, Genetics)<\/figcaption><\/figure>\n<p class=\"lead\">Dr. Hyejung Won (Assistant Professor, Genetics) received a three-year grant from the Simons Foundation Autism Research Initiative 2022 Program:\u00a0 Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies.<\/p>\n<p>Dr.\u00a0Won\u2019s project is titled \u201cReciprocal impacts of rate\u00a0and\u00a0common polygenic risk architecture for autism into biological measures\u201d.\u00a0\u00a0<em>Project abstract:<\/em>\u00a0 Genetic architecture of autism spectrum disorder (ASD) shows that both rare\u00a0and\u00a0common variation contributes to the significant proportion of heritability. While these two sets of variation in the opposite allelic spectrum have been traditionally studied in separation, the fact that rare variants with a large effect size do not have a perfect penetrance raises the idea that rare variant effects need to be understood in the polygenic background. However, the interplay between common\u00a0and\u00a0rare variation in ASD has not been systematically interrogated. Here, we propose a novel experimental paradigm in which we can systematically investigate the convergent effects of rare\u00a0and\u00a0common non-coding variants (Aim 1), together with impact of rare variants on regulatory function of common variants (Aim 2: rare to common) as well as the functional impact of rare variants under polygenic background (Aim 3: common to rare) within human neuronal context. To test the rare variant impact on regulatory architecture of common variation, we will introduce ASD-associated GWAS variants into human neurons with rare ASD gene perturbations\u00a0and\u00a0measure their allelic regulatory activity using massively parallel reporter assays (MPRA). To test the impact of polygenic architecture on rare variant function, we will introduce rare ASD risk genes into human neurons with extreme polygenic risk scores (PRS). The observed interplay between common\u00a0and\u00a0rare variants will shape our view of how variants across allelic spectrum can be studied in a unified framework than separate entities.<\/p>\n<p>Simons Foundation Award announcement <a href=\"https:\/\/www.sfari.org\/2023\/03\/23\/2022-genomics-of-asd-pathways-to-genetic-therapies-awardees-announced\/\">can be found here.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Hyejung Won (Assistant Professor, Genetics) received a three-year grant from the Simons Foundation Autism Research Initiative 2022 Program:\u00a0 Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies.<\/p>\n","protected":false},"author":28418,"featured_media":6212,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[42],"class_list":["post-12522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-won","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hyejung Won, PhD Receives Simons Foundation Award | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/hyejung-won-phd-receives-simons-foundation-award\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hyejung Won, PhD Receives Simons Foundation Award | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Dr. Hyejung Won (Assistant Professor, Genetics) received a three-year grant from the Simons Foundation Autism Research Initiative 2022 Program:\u00a0 Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/hyejung-won-phd-receives-simons-foundation-award\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-14T12:26:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-14T12:27:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/08\/hyejung-won.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"188\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jonathon Cornett\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jonathon Cornett\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/hyejung-won-phd-receives-simons-foundation-award\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/hyejung-won-phd-receives-simons-foundation-award\/\"},\"author\":{\"name\":\"Jonathon 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