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Department of Genetics faculty, postdocs, students and collaborators published nineteen papers during May 16-29, 2021.<\/p>\nDepartment of Genetics faculty, postdocs, students and collaborators published nineteen papers during May 16-29, 2021.<\/p>\n
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Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.\u00a0<\/a><\/p>\n Liang D<\/strong>, Elwell AL, Ayg\u00fcn N<\/strong>, Krupa O<\/strong>, Wolter JM, Kyere FA, Lafferty MJ<\/strong>, Cheek KE, Courtney KP, Yusupova M, Garrett ME, Ashley-Koch A, Crawford GE, Love MI<\/strong>, de la Torre-Ubieta L, Geschwind DH, Stein JL<\/strong>.<\/p>\n Nat Neurosci. 2021 May 20. doi: 10.1038\/s41593-021-00858-w. Online ahead of print.<\/p>\n PMID:\u00a034017130<\/p>\n <\/p>\n Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.\u00a0<\/a><\/p>\n Mullins N, Forstner AJ, O’Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, B\u00f8rte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH, Abramova L, Adorjan K, Agerbo E, Al Eissa M, Albani D, Alliey-Rodriguez N, Anjorin A, Antilla V, Antoniou A, Awasthi S, Baek JH, B\u00e6kvad-Hansen M, Bass N, Bauer M, Beins EC, Bergen SE, Birner A, B\u00f8cker Pedersen C, B\u00f8en E, Boks MP, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cairns M, Casas M, Cervantes P, Clarke TK, Cruceanu C, Cuellar-Barboza A, Cunningham J, Curtis D, Czerski PM, Dale AM, Dalkner N, David FS, Degenhardt F, Djurovic S, Dobbyn AL, Douzenis A, Elvs\u00e5shagen T, Escott-Price V, Ferrier IN, Fiorentino A, Foroud TM, Forty L, Frank J, Frei O, Freimer NB, Fris\u00e9n L, Gade K, Garnham J, Gelernter J, Gi\u00f8rtz Pedersen M, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha K, Haraldsson M, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hoffmann P, Holmans PA, Huckins L, Jamain S, Johnson JS, Kalman JL, Kamatani Y, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koromina M, Kranz TM, Kranzler HR, Kubo M, Kupka R, Kushner SA, Lavebratt C, Lawrence J, Leber M, Lee HJ, Lee PH, Levy SE, Lewis C, Liao C, Lucae S, Lundberg M, MacIntyre DJ, Magnusson SH, Maier W, Maihofer A, Malaspina D, Maratou E, Martinsson L, Mattheisen M, McCarroll SA, McGregor NW, McGuffin P, McKay JD, Medeiros H, Medland SE, Millischer V, Montgomery GW, Moran JL, Morris DW, M\u00fchleisen TW, O’Brien N, O’Donovan C, Olde Loohuis LM, Oruc L, Papiol S, Pardi\u00f1as AF, Perry A, Pfennig A, Porichi E, Potash JB, Quested D, Raj T, Rapaport MH, DePaulo JR, Regeer EJ, Rice JP, Rivas F, Rivera M, Roth J, Roussos P, Ruderfer DM, S\u00e1nchez-Mora C, Schulte EC, Senner F, Sharp S, Shilling PD, Sigurdsson E, Sirignano L, Slaney C, Smeland OB, Smith DJ, Sobell JL, S\u00f8holm Hansen C, Soler Artigas M, Spijker AT, Stein DJ, Strauss JS, \u015awi\u0105tkowska B, Terao C, Thorgeirsson TE, Toma C, Tooney P, Tsermpini EE, Vawter MP, Vedder H, Walters JTR, Witt SH, Xi S, Xu W, Yang JMK, Young AH, Young H, Zandi PP, Zhou H, Zillich L; HUNT All-In Psychiatry, Adolfsson R, Agartz I, Alda M, Alfredsson L, Babadjanova G, Backlund L, Baune BT, Bellivier F, Bengesser S, Berrettini WH, Blackwood DHR, Boehnke M, B\u00f8rglum AD, Breen G, Carr VJ, Catts S, Corvin A, Craddock N, Dannlowski U, Dikeos D, Esko T, Etain B, Ferentinos P, Frye M, Fullerton JM, Gawlik M, Gershon ES, Goes FS, Green MJ, Grigoroiu-Serbanescu M, Hauser J, Henskens F, Hillert J, Hong KS, Hougaard DM, Hultman CM, Hveem K, Iwata N, Jablensky AV, Jones I, Jones LA, Kahn RS, Kelsoe JR, Kirov G, Land\u00e9n M, Leboyer M, Lewis CM, Li QS, Lissowska J, Lochner C, Loughland C, Martin NG, Mathews CA, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Michie P, Milani L, Mitchell PB, Morken G, Mors O, Mortensen PB, Mowry B, M\u00fcller-Myhsok B, Myers RM, Neale BM, Nievergelt CM, Nordentoft M, N\u00f6then MM, O’Donovan MC, Oedegaard KJ, Olsson T, Owen MJ, Paciga SA, Pantelis C, Pato C, Pato MT, Patrinos GP, Perlis RH, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, Ribas\u00e9s M, Rietschel M, Ripke S, Rouleau GA, Saito T, Schall U, Schalling M, Schofield PR, Schulze TG, Scott LJ, Scott RJ, Serretti A, Shannon Weickert C, Smoller JW, Stefansson H, Stefansson K, Stordal E, Streit F, Sullivan PF<\/strong>, Turecki G, Vaaler AE, Vieta E, Vincent JB, Waldman ID, Weickert TW, Werge T, Wray NR, Zwart JA, Biernacka JM, Nurnberger JI, Cichon S, Edenberg HJ, Stahl EA, McQuillin A, Di Florio A, Ophoff RA, Andreassen OA.<\/p>\n Nat Genet. 2021 May 17. doi: 10.1038\/s41588-021-00857-4. Online ahead of print.<\/p>\n PMID:\u00a034002096<\/p>\n <\/p>\n Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits.\u00a0<\/a><\/p>\n Zhao B, Shan Y, Yang Y, Yu Z, Li T, Wang X, Luo T, Zhu Z, Sullivan P<\/strong>, Zhao H, Li Y,<\/strong> Zhu H.<\/p>\n Nat Commun. 2021 May 17;12(1):2878. doi: 10.1038\/s41467-021-23130-y.<\/p>\n PMID:\u00a034001886<\/p>\n <\/p>\n Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2021 update: a policy statement of the American College of Medical Genetics and Genomics (ACMG).\u00a0<\/a><\/p>\n Miller DT, Lee K<\/strong>, Gordon AS, Amendola LM, Adelman K, Bale SJ, Chung WK, Gollob MH, Harrison SM, Herman GE, Hershberger RE, Klein TE, McKelvey K, Richards CS, Vlangos CN, Stewart DR, Watson MS, Martin CL; ACMG Secondary Findings Working Group.<\/p>\n Genet Med. 2021 May 20. doi: 10.1038\/s41436-021-01171-4. Online ahead of print.<\/p>\n PMID:\u00a034012069<\/p>\n <\/p>\n ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG).\u00a0<\/a><\/p>\n Miller DT, Lee K<\/strong>, Chung WK, Gordon AS, Herman GE, Klein TE, Stewart DR, Amendola LM, Adelman K, Bale SJ, Gollob MH, Harrison SM, Hershberger RE, McKelvey K, Richards CS, Vlangos CN, Watson MS, Martin CL; ACMG Secondary Findings Working Group.<\/p>\n Genet Med. 2021 May 20. doi: 10.1038\/s41436-021-01172-3. Online ahead of print.<\/p>\n PMID:\u00a034012068<\/p>\n <\/p>\n A vertebrate adaptive radiation is assembled from an ancient and disjunct spatiotemporal landscape.\u00a0<\/a><\/p>\n Richards EJ, McGirr JA, Wang JR<\/strong>, St John ME, Poelstra JW, Solano MJ, O’Connell DC, Turner BJ, Martin CH.<\/p>\n Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2011811118. doi: 10.1073\/pnas.2011811118.<\/p>\n PMID:\u00a033990463<\/p>\n <\/p>\n Genetic effects on liver chromatin accessibility identify disease regulatory variants.\u00a0<\/a><\/p>\n Currin KW<\/strong>, Erdos MR, Narisu N, Rai V, Vadlamudi S, Perrin HJ<\/strong>, Idol JR, Yan T, Albanus RD, Broadaway KA,<\/strong> Etheridge AS, Bonnycastle LL, Orchard P, Didion JP, Chaudhry AS; NISC Comparative Sequencing Program, Innocenti F, Schuetz EG, Scott LJ, Parker SCJ, Collins FS, Mohlke KL<\/strong>.<\/p>\n Am J Hum Genet. 2021 May 20:S0002-9297(21)00185-3. doi: 10.1016\/j.ajhg.2021.05.001. Online ahead of print.<\/p>\n PMID:\u00a034038741<\/p>\n <\/p>\n Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure.\u00a0<\/a><\/p>\n Baranowski BJ, Allen MD, Nyarko JN, Rector RS, Padilla J, Mousseau DD, Rau CD<\/strong>, Wang Y, Laughlin MH, Emter CA, MacPherson RE, Olver TD.<\/p>\n JCI Insight. 2021 May 24;6(10):143141. doi: 10.1172\/jci.insight.143141.<\/p>\n PMID:\u00a034027891<\/p>\n <\/p>\n Segmentor: a tool for manual refinement of 3D microscopy annotations.\u00a0<\/a><\/p>\n Borland D, McCormick CM, Patel NK, Krupa O, Mory JT, Beltran AA, Farah TM, Escobar-Tomlienovich CF, Olson SS,<\/strong> Kim M, Wu G, Stein JL<\/strong>.<\/p>\n BMC Bioinformatics. 2021 May 22;22(1):260. doi: 10.1186\/s12859-021-04202-8.<\/p>\n PMID:\u00a034022787<\/p>\n <\/p>\n Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.\u00a0<\/a><\/p>\n Malawsky DS, Weir SJ, Ocasio JK, Babcock B, Dismuke T, Cleveland AH, Donson AM, Vibhakar R, Wilhelmsen K<\/strong>, Gershon TR.<\/p>\n Commun Biol. 2021 May 21;4(1):616. doi: 10.1038\/s42003-021-02099-w.<\/p>\n PMID:\u00a034021242<\/p>\n <\/p>\n Influenza Virus and SARS-CoV-2 Vaccines.\u00a0<\/a><\/p>\n Sandor AM<\/strong>, Sturdivant MS, Ting JPY.<\/strong><\/p>\n J Immunol. 2021 Jun 1;206(11):2509-2520. doi: 10.4049\/jimmunol.2001287. Epub 2021 May 21.<\/p>\n PMID:\u00a034021048<\/p>\n <\/p>\n Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.\u00a0<\/a><\/p>\n Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, Hardy D, Snouwaert JN, Koller BH<\/strong>, Serra V, Bruhns P, Grouard-Vogel G, Reber LL.<\/p>\n Nat Commun. 2021 May 11;12(1):2574. doi: 10.1038\/s41467-021-22834-5.<\/p>\n PMID:\u00a033976140<\/p>\n <\/p>\n Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.\u00a0<\/a><\/p>\n Morton LM, Karyadi DM, Stewart C, Bogdanova TI, Dawson ET, Steinberg MK, Dai J, Hartley SW, Schonfeld SJ, Sampson JN, Maruvka YE, Kapoor V, Ramsden DA, Carvajal-Garcia J,<\/strong> Perou CM, Parker JS<\/strong>, Krznaric M, Yeager M, Boland JF, Hutchinson A, Hicks BD, Dagnall CL, Gastier-Foster JM, Bowen J, Lee O, Machiela MJ, Cahoon EK, Brenner AV, Mabuchi K, Drozdovitch V, Masiuk S, Chepurny M, Zurnadzhy LY, Hatch M, Berrington de Gonzalez A, Thomas GA, Tronko MD, Getz G, Chanock SJ.<\/p>\n Science. 2021 May 14;372(6543):eabg2538. doi: 10.1126\/science.abg2538. Epub 2021 Apr 22.<\/p>\n PMID:\u00a033888599<\/p>\n <\/p>\n Transcriptomic analyses of gastrulation-stage C57BL\/6J and C57BL\/6NHsd mouse embryos with differential susceptibility to alcohol.\u00a0<\/a><\/p>\n Boschen KE, Ptacek TS, Berginski ME, Simon JM<\/strong>, Parnell SE.<\/p>\n Dis Model Mech. 2021 May 27:dmm.049012. doi: 10.1242\/dmm.049012. Online ahead of print.<\/p>\n PMID:\u00a034042959<\/p>\n <\/p>\n Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL.\u00a0<\/a><\/p>\n Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J<\/strong>, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG.<\/p>\n Blood. 2021 Jan 28;137(4):471-484. doi: 10.1182\/blood.2020006287.<\/p>\n PMID:\u00a032881995<\/p>\n <\/p>\n WEVar: a novel statistical learning framework for predicting noncoding regulatory variants.\u00a0<\/a><\/p>\n Wang Y, Jiang Y<\/strong>, Yao B, Huang K, Liu Y<\/strong>, Wang Y, Qin X, Saykin AJ, Chen L.<\/p>\n Brief Bioinform. 2021 May 22:bbab189. doi: 10.1093\/bib\/bbab189. Online ahead of print.<\/p>\n PMID:\u00a034021560<\/p>\n <\/p>\n Permutation-based identification of important biomarkers for complex diseases via machine learning models.\u00a0<\/a><\/p>\n Mi X, Zou B, Zou F<\/strong>, Hu J.<\/p>\n Nat Commun. 2021 May 21;12(1):3008. doi: 10.1038\/s41467-021-22756-2.<\/p>\n PMID:\u00a034021151<\/p>\n <\/p>\n