My research background is in Neurobiology and I have used genetic, cellular, and molecular biology techniques to study aspects of normal development, as well as disease. During my doctoral training I was involved in two major projects aimed at better understanding genetic risk factors for schizophrenia, including retinoic acid signaling, and 22q11.2 deletion syndrome. I mapped CNS sites of retinoic acid signaling, and 22q11.2 gene expression, in the developing and adult brain. Using mice as a model system, I showed that adult brain cells respond to retinoic acid\u00a0in vivo<\/i>, including neural stem cells. Subsequently, I continued to evaluate the hypothesis that so-called \u201cdevelopmental\u201d signaling molecules are re-activated both during adulthood, to mediate cellular plasticity, as well as during pathogenic states, such as cancer. As a postdoctoral research associate at Duke University, I investigated the role of Fgf and Wnt signaling during cerebellar development, as well as in medulloblastoma, a malignant cerebellar tumor that primarily affects children. Thus, I have broad training in pre-clinical neurogenetics.<\/p>\n
More recently, I have been involved in the development and application of genetic tests for clinical purposes, such as diagnostics, treatment monitoring, and pharmacogenomics. I have significant industry experience signing out high-throughput sequencing results, and am currently serving as a molecular analyst for the NCGENES exome sequencing clinical trial. My research in the Berg lab is aimed at examining the diagnostic and research utility of whole exome sequencing in a clinically diverse set of patients. In those patients for whom we are not able to provide a diagnosis using current disease gene lists, I manually curate the exome data in search of novel causal variants. I am currently focused on analyzing exome data from cardio-genetic and neuro-genetic patients, and have identified candidate disease variants in a subset of severely affected cardiac patients. As the clinical use of genome-scale sequencing technologies escalates, adjudication of resulting variants will continue to be a central issue. Accordingly, my research efforts are focused on validating novel genomic variants using biological and bio-informatics-based approaches, in order to inform the development of analytical frameworks for variant interpretation.<\/p>\n","protected":false},"excerpt":{"rendered":"
My research background is in Neurobiology and I have used genetic, cellular, and molecular biology techniques to study aspects of normal development, as well as disease. During my doctoral training I was involved in two major projects aimed at better understanding genetic risk factors for schizophrenia, including retinoic acid signaling, and 22q11.2 deletion syndrome. I … Read more<\/a><\/p>\n","protected":false},"featured_media":2216,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-3410","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Gloria Haskell, Ph.D."],"_upd_reverse_display_name":["Haskell, Gloria"],"_upd_last_name":["Haskell"],"_upd_first_name":["Gloria"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":[],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"gloria_haskell@med.unc.edu"}]],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/directory\/3410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/directory\/3410\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/media\/2216"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/genetics\/berglab\/wp-json\/wp\/v2\/media?parent=3410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}