1.0Gene Therapy Center/genetherapyAmanda Dobbins/genetherapy/author/adobbins/rich600338<blockquote class="wp-embedded-content" data-secret="oOoliemmSu"><a href="/genetherapy/research-laboratories/li-lab/chengwen-li/">Chengwen Li</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="/genetherapy/research-laboratories/li-lab/chengwen-li/embed/#?secret=oOoliemmSu" width="600" height="338" title="“Chengwen Li” — Gene Therapy Center" data-secret="oOoliemmSu" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript"> /* <![CDATA[ */ /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); /* ]]> */ </script>   Research Interests AAV vectors have been successfully applied in clinical trials in patients with eye and liver diseases. Several challenges limit AAV application including the capsid specific CTL response, AAV neutralizing antibody presence in human population, late innate immune response after AAV transduction and low transduction efficiency of AAV vector in humans. In light … Read more