黑料网

The research team in the Dayton Lab is investigating the comprehensive landscape of contrast-enhanced ultrasound, for both imaging and therapeutic applications. By combining ultrasound waves with acoustically responsive particles, such as microbubbles or phase-shift nanoemulsions, they are developing new high-contrast, high-detail vascular imaging methods which can be used to assess angiogenesis, brain cancer biomarkers and brain perfusion. Additionally, through careful control of ultrasound parameters, they use ultrasound to induce biologic effects to enhance non-invasive delivery of compounds into the brain, and directly stimulate neuronal action. As a consortium member, the Dayton Lab is investigating the non-invasive delivery of molecular, gene and cell-based therapies to the brain using focused ultrasound.聽

Dr. Dotti鈥檚 laboratory research involves developing chimeric antigen receptor (CAR) based strategies to target solid tumors, including pediatric neuroblastoma. A significant focus of the Dotti Lab鈥檚 research is the development of strategies of T cell engineering aimed at overcoming immune suppressive mechanisms of the tumor microenvironment. This includes ongoing clinical trials exploring CAR-T cell efficacy in the brain at 黑料网. Current preclinical investigations include the use of focused ultrasound to drive tumor changes to improve T-cell efficacy in glioblastoma. 聽

Dr. Favorov鈥檚 research is structured around neural bases of perception, with special emphasis on the relationship between patterns of neuroelectrical activity in the somatosensory cerebral cortex and tactile and pain perception, including the physiological mechanisms responsible for the generation of neuroelectrical activity in the cerebral cortex and cortical information processing. In order to understand the functional significance of the experimentally observed cortical activity patterns, his group has developed computational algorithms that analyze how the cerebral cortex is able to recognize higher-order regularities in observed phenomena and how these patterns are used in perceptual and decision-making tasks. Dr. Favorov also studies the neural effects of electrical deep brain stimulation, such as used to treat Parkinson鈥檚 patients, and transcranial focused ultrasound stimulation. 聽

The vision of the Frohlich Lab is that understanding cortical state dynamics will enable the development of novel non-invasive brain stimulation paradigms that directly target pathological network dynamics. Such a rational design of neurotherapeutics will open the door for individualized, highly effective brain stimulation in psychiatry. In addition to Dr. Frohlich鈥檚 research program, he directs the that offers numerous clinical trials of novel experimental treatments for depression and mental illness.聽

Adam Hantman, PhD

By combining anatomy, physiology, and specific (genetic and temporal) manipulations, the Hantman Lab uses a dynamical systems approach to identify and understand the neural elements responsible for skillful motor control. Currently, they are exploring the role of the cortico-cerebellar loop in a learned behavior task in the rodent with functional ultrasound imaging and focused ultrasound neuromodulation.聽

Dominique Higgins, MD, PhD

Dr. Higgins is the Director of Adult Neurosurgical Oncology, and specializes in malignant and benign brain tumors. His research is focused on improving local delivery of novel therapeutics to brain tumors using focused ultrasound, and targeting metabolism to better diagnose and treat these tumors. The Higgins Lab has developed pre-clinical models of glioblastoma, and is studying dietary strategies that enhance targeted programmed cell death by ferroptosis, molecular imaging strategies to track tumor progression, and local delivery of ferroptosis-inducing therapies.聽

Due to their expansive utility, stem cell-based therapies hold the potential to redefine therapeutic approaches and provide cures for many terminal diseases. In the Hingtgen lab, they seek to harness the potential of stem cells to develop new and better methods for treating terminal cancers, including brain, breast, lung, and others. Using an integrative approach, they design and create targeted therapeutic proteins which are then used to 鈥渁rm鈥� different stem cell types with the anti-cancer molecules to improve both drug delivery and cancer cell killing potential of stem cell-based therapies. By bringing together the tools and techniques of molecular biology, viral vectors, targeted therapeutics, stem cell biology, and molecular imaging with highly translatable animal models, the Hingtgen Lab aims to ultimately bring successful cell-based treatments for multiple tumor types into the clinics.聽

Vibhor Krishna, MD

In addition to leading 黑料网鈥檚 clinical focused ultrasound program, functional neurosurgeon Dr. Vibhor Krishna鈥檚 laboratory research centers on optimizing less- and non-invasive neurosurgery by pairing advanced functional imaging with neurosurgical or neuromodulatory interventions. The Krishna Lab performs cutting-edge translational research to improve patient care and advance our understanding of brain structure and function.

Soma Sengupta, MD, PhD & Daniel Pomeranz Krummel, PhD

The joint laboratory of Soma Sengupta and Daniel Pomeranz Krummel at the 黑料网 focuses on study of the importance of membrane transport proteins to maintain the brain tumor microenvironment and advancing therapeutic approaches to modulate this environment. Sengupta is a clinician-trialist with a research background in clinically important membrane transport proteins. She is a clinical trialist, a board-certified neuro-oncologist, Chief of Neuro-Oncology, and a Vice-Chair of Research whose clinical practice is primarily focused on adult brain tumor patients. Pomeranz Krummel is a biochemist with a long-standing interest in gene expression mechanisms as well as translational neuro-oncology. Their research effort has included collaborative studies in the focused ultrasound space and application of various bioengineering technologies.

Dr. Lee is the Vice Chair of Translational Radiology in the Department of Radiology and a clinical Neuroradiologist. In the pre-clinical realm, he is an expert on advanced imaging approaches in multiple species and different scale models using all medical imaging modalities, including MRI, ultrasound, and CT. His research interests include advanced imaging approaches to the brain and other organs in multiple species. 聽

Weili Lin, MD, PhD

The laboratory of Dr. Lin鈥檚 research interests are two-fold: Investigating magnetic resonance (MR) as a means to learn about structural and functional brain maturation, and using PET and MR imaging to research cerebral ischemia, both pre-clinically and clinically. As the Director of the Biomedical Research Imaging Center, which houses 黑料网鈥檚 two clinical MR-guided FUS systems, Dr. Lin supports numerous investigators conducting translational brain research.聽

Dr. Mihalik鈥檚 primary research looks at the intersection of head trauma biomechanics with clinical outcomes in civilian athletes and military warfighters, by investigating the effectiveness of innovative concussion assessment, management, and rehabilitation technologies with neuroimaging and neurophysiology. He is the Director of the Matthew Gfeller Center, a leading research center dedicated to studying traumatic brain injuries (TBI) in athletes, service members, and first responders. Its interdisciplinary team conducts cutting-edge research on brain health, neuroimaging, and rehabilitation while developing innovative clinical approaches to improve outcomes for those affected by concussion and neurotrauma. The center also leads initiatives like the THRIVE Program, providing specialized care and support for Veterans and first responders with TBI and post-traumatic stress.

Dr. Philpot aims to understand the molecular, cellular, and circuit-level basis for the pathophysiology underlying monogenic neurodevelopmental disorders. This philosophy guides the research of the Philpot lab, whose research team uses this information to identify and validate novel therapeutics for monogenic diseases such as Angelman, Pitt-Hopkins, and Dup15q syndromes. As part of CCUBIT, the Philpot lab is working to improve brain-wide delivery of corrective viral vector therapies for treating CNS disorders using FUS-mediated blood-brain barrier disruption.聽

The Pinton Lab focuses on advancing ultrasound imaging technologies with groundbreaking methods for enhanced resolution and functional imaging in both the brain and abdomen. The lab鈥檚 research is centered on developing innovative imaging techniques, such as super-resolution vascular imaging, functional imaging, and shock wave imaging, while also creating models to simulate nonlinear wave propagation in the human body, including acoustical and shear shocks. The Pinton Lab鈥檚 expertise in super-resolution imaging, functional imaging, and transcranial wave propagation is applied across a variety of clinical and pre-clinical applications, including machine learning-based beamforming.聽

Kimberly Ritola, PhD

With her extensive background in genetics and viral design, Dr. Ritola leads the viral vector core, with a focus on optimization and development of viral vectors for the broader neuroscience community. The Core works directly with investigators in CCUBIT and across campus to provide custom viral vectors tailored for neuroscience experiments, and is instrumental in efficient design and synthesis of viral vectors for gene delivery experiments utilizing focused ultrasound to open the blood-brain barrier.聽

Ian Shih, PhD

Dr. Ian Shih is a Professor and Vice Chair for Research in Neurology at 黑料网. As Director of the Center for Animal MRI and Associate Director of the Biomedical Research Imaging Center, he supports a wide range of interdisciplinary imaging projects across the university. His research focuses on developing functional MRI (fMRI) techniques and integrating advanced neuromodulation and recording tools to study brain circuits and network dynamics in animal models such as stroke and Parkinson鈥檚 disease. He is also exploring the use of ultrasound imaging and modulation for MRI-related applications.聽

Dr. Zylka is the Director of the 黑料网 Neuroscience Center, with a research focus of understanding genetic and environmental risk factors for autism, and molecular mechanisms underlying pain sensation. The Zylka lab is exploring the use of CRISPR/Cas and viral vector delivery to the central nervous system for the treatment of Angelman Syndrome, a single-gene neurodevelopmental disorder.聽