{"id":2250,"date":"2011-05-10T15:30:00","date_gmt":"2011-05-10T19:30:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/csb\/macinfac\/macinfac-2\/publication\/"},"modified":"2024-09-25T16:35:10","modified_gmt":"2024-09-25T20:35:10","slug":"publication","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/csb\/macinfac\/publication\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

Designer peptide-DNA cytoskeletons regulate the function of synthetic cells.<\/a>
\nDaly ML, Nishi K, Klawa SJ, Hinton KY, Gao Y, Freeman R.
\nNat Chem. 2024 Aug;16(8):1229-1239. doi: 10.1038\/s41557-024-01509-w. Epub 2024 Apr 23.
\nPMID:\u00a038654104\u00a0Free PMC article.<\/strong><\/p>\n

Contribution of Electrostatic CH3-\u03c0 Interactions to Recognition of Histone Asymmetric Dimethylarginine by the SPIN1 Triple Tudor Domain.<\/a>
\nTravis CR, Dumais RG, Treacy JW, Kean KM, Houk KN, Waters ML.
\nJ Am Chem Soc. 2024 Jul 31;146(30):20678-20684. doi: 10.1021\/jacs.4c03463. Epub 2024 Jul 18.
\nPMID:\u00a039023428<\/p>\n

Dynamic Implications of Noncovalent Interactions in Amphiphilic Single-Chain Polymer Nanoparticles.<\/a>
\nDykeman-Bermingham PA, Stingaciu LR, Do C, Knight AS.
\nACS Macro Lett. 2024 Jul 16;13(7):889-895. doi: 10.1021\/acsmacrolett.4c00269. Epub 2024 Jul 3.
\nPMID:\u00a038959296<\/p>\n

Leveraging Triphenylphosphine-Containing Polymers to Explore Design Principles for Protein-Mimetic Catalysts.<\/a>
\nSanders MA, Chittari SS, Foley JR, Swofford WM, Elder BM, Knight AS.
\nJ Am Chem Soc. 2024 Jun 26;146(25):17404-17413. doi: 10.1021\/jacs.4c05040. Epub 2024 Jun 11.
\nPMID:\u00a038863219<\/p>\n

Gut microbial \u03b2-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.<\/a>
\nSimpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, Lu K, Redinbo MR.
\nCell Host Microbe. 2024 Jun 12;32(6):925-944.e10. doi: 10.1016\/j.chom.2024.04.018. Epub 2024 May 15.
\nPMID:\u00a038754417<\/p>\n

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1.<\/a>
\nBonner X, Sondgeroth A, McCue A, Nicely N, Tripathy A, Spielvogel E, Moeser M, Ke R, Leiderman K, Joseph SB, Swanstrom R.
\nmBio. 2024 Apr 10;15(4):e0032124. doi: 10.1128\/mbio.00321-24. Epub 2024 Mar 1.
\nPMID:\u00a038426750\u00a0Free PMC article.<\/strong><\/p>\n

A divergent tumor overexpressed gene domain and oligomerization contribute to SPIRAL2 function in stabilizing microtubule minus ends.<\/a>
\nFan Y, Bilkey N, Bolhuis DL, Slep KC, Dixit R.
\nPlant Cell. 2024 Mar 29;36(4):1056-1071. doi: 10.1093\/plcell\/koad294.
\nPMID:\u00a038011314\u00a0Free PMC article.<\/strong><\/p>\n

Tailoring Hierarchical Structure and Rare Earth Affinity of Compositionally Identical Polymers via Sequence Control.<\/a>
\nDykeman-Bermingham PA, Bogen MP, Chittari SS, Grizzard SF, Knight AS.
\nJ Am Chem Soc. 2024 Mar 27;146(12):8607-8617. doi: 10.1021\/jacs.4c00440. Epub 2024 Mar 12.
\nPMID:\u00a038470430<\/p>\n

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.<\/a>
\nCarlson DL, Kowalewski M, Bodoor K, Lietzan AD, Hughes PF, Gooden D, Loiselle DR, Alcorta D, Dingman Z, Mueller EA, Irnov I, Modla S, Chaya T, Caplan J, Embers M, Miller JC, Jacobs-Wagner C, Redinbo MR, Spector N, Haystead TAJ.
\nCell Chem Biol. 2024 Mar 21;31(3):465-476.e12. doi: 10.1016\/j.chembiol.2023.10.004. Epub 2023 Nov 1.
\nPMID:\u00a037918401<\/p>\n

The Dilute domain in Canoe is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness.<\/a>
\nMcParland ED, Butcher TA, Gurley NJ, Johnson RI, Slep KC, Peifer M.
\nJ Cell Sci. 2024 Mar 15;137(6):jcs261734. doi: 10.1242\/jcs.261734. Epub 2024 Mar 21.
\nPMID:\u00a038323935\u00a0Free PMC article.<\/strong><\/p>\n

Trimethyllysine Reader Proteins Exhibit Widespread Charge-Agnostic Binding via Different Mechanisms to Cationic and Neutral Ligands.<\/a>
\nTravis CR, Kean KM, Albanese KI, Henriksen HC, Treacy JW, Chao EY, Houk KN, Waters ML.
\nJ Am Chem Soc. 2024 Feb 7;146(5):3086-3093. doi: 10.1021\/jacs.3c10031. Epub 2024 Jan 24.
\nPMID:\u00a038266163<\/p>\n

Uncovering supramolecular chirality codes for the design of tunable biomaterials.<\/a>
\nKlawa SJ, Lee M, Riker KD, Jian T, Wang Q, Gao Y, Daly ML, Bhonge S, Childers WS, Omosun TO, Mehta AK, Lynn DG, Freeman R.
\nNat Commun. 2024 Jan 26;15(1):788. doi: 10.1038\/s41467-024-45019-2.
\nPMID:\u00a038278785\u00a0Free PMC article.<\/strong><\/p>\n

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy.<\/a>
\nMcCue AC, Demarest SJ, Froning KJ, Hickey MJ, Antonysamy S, Kuhlman B.
\nMAbs. 2024 Jan-Dec;16(1):2373325. doi: 10.1080\/19420862.2024.2373325. Epub 2024 Jul 4.
\nPMID:\u00a038962811\u00a0Free PMC article.<\/strong><\/p>\n

Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain.<\/a>
\nBolhuis DL, Dixit R, Slep KC.
\nPLoS One. 2023 Dec 29;18(12):e0290024. doi: 10.1371\/journal.pone.0290024. eCollection 2023.
\nPMID:\u00a038157339\u00a0Free PMC article.<\/strong><\/p>\n

In silico evolution of autoinhibitory domains for a PD-L1 antagonist using deep learning models.<\/a>
\nGoudy OJ, Nallathambi A, Kinjo T, Randolph NZ, Kuhlman B.
\nProc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2307371120. doi: 10.1073\/pnas.2307371120. Epub 2023 Nov 30.
\nPMID:\u00a038032933\u00a0Free PMC article.<\/strong><\/p>\n

Stepwise requirements for polymerases \u03b4 and \u03b8 in theta-mediated end joining.<\/a>
\nStroik S, Carvajal-Garcia J, Gupta D, Edwards A, Luthman A, Wyatt DW, Dannenberg RL, Feng W, Kunkel TA, Gupta GP, Hedglin M, Wood R, Doubli\u00e9 S, Rothenberg E, Ramsden DA.
\nNature. 2023 Nov;623(7988):836-841. doi: 10.1038\/s41586-023-06729-7. Epub 2023 Nov 15.
\nPMID:\u00a037968395<\/p>\n

Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.<\/a>
\nShell DJ, Foley CA, Wang Q, Smith CM, Guduru SKR, Zeng H, Dong A, Norris-Drouin JL, Axtman M, Hardy PB, Gupta G, Halabelian L, Frye SV, James LI, Pearce KH.
\nJ Med Chem. 2023 Oct 26;66(20):14133-14149. doi: 10.1021\/acs.jmedchem.3c01192. Epub 2023 Oct 2.
\nPMID:\u00a037782247\u00a0Free PMC article.<\/strong><\/p>\n

Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing.<\/a>
\nLeighton GO, Shang S, Hageman S, Ginder GD, Williams DC Jr.
\nProc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2307287120. doi: 10.1073\/pnas.2307287120. Epub 2023 Aug 8.
\nPMID:\u00a037552759\u00a0Free PMC article.<\/strong><\/p>\n

Trifluoroethanol and the behavior of a tardigrade desiccation-tolerance protein.<\/a>
\nWang S, Eicher J, Pielak GJ.
\nProtein Sci. 2023 Aug;32(8):e4716. doi: 10.1002\/pro.4716.
\nPMID:\u00a037401908\u00a0Free PMC article.<\/strong><\/p>\n

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins.<\/a>
\nCummins MC, Tripathy A, Sondek J, Kuhlman B.
\nProtein Sci. 2023 Aug;32(8):e4713. doi: 10.1002\/pro.4713.
\nPMID:\u00a037368504\u00a0Free PMC article.<\/strong><\/p>\n

Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly.<\/a>
\nRyniawec JM, Buster DW, Slevin LK, Boese CJ, Amoiroglou A, Dean SM, Slep KC, Rogers GC.
\nMol Biol Cell. 2023 Jul 1;34(8):ar80. doi: 10.1091\/mbc.E22-12-0572. Epub 2023 May 10.
\nPMID:\u00a037163316\u00a0Free PMC article.<\/strong><\/p>\n

MBD2a-NuRD binds to the methylated \u03b3-globin gene promoter and uniquely forms a complex required for silencing of HbF expression.<\/a>
\nShang S, Li X, Azzo A, Truong T, Dozmorov M, Lyons C, Manna AK, Williams DC Jr, Ginder GD.
\nProc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2302254120. doi: 10.1073\/pnas.2302254120. Epub 2023 Jun 12.
\nPMID:\u00a037307480\u00a0Free PMC article.<\/strong><\/p>\n

Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles.<\/a>
\nStingley KJ, Carpenter BA, Kean KM, Waters ML.
\nChem Sci. 2023 Apr 3;14(18):4935-4944. doi: 10.1039\/d3sc00231d. eCollection 2023 May 10.
\nPMID:\u00a037181761\u00a0Free PMC article.<\/strong><\/p>\n

Microbial \u03b2-glucuronidases drive human periodontal disease etiology.<\/a>
\nLietzan AD, Simpson JB, Walton WG, Jariwala PB, Xu Y, Boynton MH, Liu J, Redinbo MR.
\nSci Adv. 2023 May 5;9(18):eadg3390. doi: 10.1126\/sciadv.adg3390. Epub 2023 May 5.
\nPMID:\u00a037146137\u00a0Free PMC article.<\/strong><\/p>\n

Versatile Triphenylphosphine-Containing Polymeric Catalysts and Elucidation of Structure-Function Relationships.<\/a>
\nSanders MA, Chittari SS, Sherman N, Foley JR, Knight AS.
\nJ Am Chem Soc. 2023 May 3;145(17):9686-9692. doi: 10.1021\/jacs.3c01092. Epub 2023 Apr 20.
\nPMID:\u00a037079910<\/p>\n

SARS-CoV-2 evolved variants optimize binding to cellular glycocalyx.<\/a>
\nKim SH, Kearns FL, Rosenfeld MA, Votapka L, Casalino L, Papanikolas M, Amaro RE, Freeman R.
\nCell Rep Phys Sci. 2023 Apr 19;4(4):101346. doi: 10.1016\/j.xcrp.2023.101346. Epub 2023 Apr 7.
\nPMID:\u00a037077408\u00a0Free PMC article.<\/strong><\/p>\n

Structure-first identification of RNA elements that regulate dengue virus genome architecture and replication.<\/a>
\nBoerneke MA, Gokhale NS, Horner SM, Weeks KM.
\nProc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2217053120. doi: 10.1073\/pnas.2217053120. Epub 2023 Apr 3.
\nPMID:\u00a037011200\u00a0Free PMC article.<\/strong><\/p>\n

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.<\/a>
\nFoley MH, Walker ME, Stewart AK, O’Flaherty S, Gentry EC, Patel S, Beaty VV, Allen G, Pan M, Simpson JB, Perkins C, Vanhoy ME, Dougherty MK, McGill SK, Gulati AS, Dorrestein PC, Baker ES, Redinbo MR, Barrangou R, Theriot CM.
\nNat Microbiol. 2023 Apr;8(4):611-628. doi: 10.1038\/s41564-023-01337-7. Epub 2023 Mar 13.
\nPMID:\u00a036914755\u00a0Free PMC article.<\/strong><\/p>\n

Designer installation of a substrate recruitment domain to tailor enzyme specificity.<\/a>
\nPark R, Ongpipattanakul C, Nair SK, Bowers AA, Kuhlman B.
\nNat Chem Biol. 2023 Apr;19(4):460-467. doi: 10.1038\/s41589-022-01206-0. Epub 2022 Dec 12.
\nPMID:\u00a036509904\u00a0Free PMC article.<\/strong><\/p>\n

De novo<\/em>\u00a0design of stable proteins that efficaciously inhibit oncogenic G proteins.<\/a>
\nCummins MC, Tripathy A, Sondek J, Kuhlman B.
\nbioRxiv [Preprint]. 2023 Mar 28:2023.03.28.534629. doi: 10.1101\/2023.03.28.534629.
\nUpdate in:Protein Sci. 2023 Aug;32(8):e4713. doi: 10.1002\/pro.4713.<\/a>
\nPMID:\u00a037034763\u00a0Free PMC article.<\/strong>\u00a0Preprint.<\/p>\n

Investigating Fundamental Principles of Nonequilibrium Assembly Using Temperature-Sensitive Copolymers.<\/a>
\nChittari SS, Obermeyer AC, Knight AS.
\nJ Am Chem Soc. 2023 Mar 22;145(11):6554-6561. doi: 10.1021\/jacs.3c00883. Epub 2023 Mar 13.
\nPMID:\u00a036913711<\/p>\n

32.<\/p>\n

Macromolecular Crowding by Polyethylene Glycol Reduces Protein Breathing.<\/a>
\nChu IT, Hutcheson BO, Malsch HR, Pielak GJ.
\nJ Phys Chem Lett. 2023 Mar 16;14(10):2599-2605. doi: 10.1021\/acs.jpclett.3c00271. Epub 2023 Mar 7.
\nPMID:\u00a036881386<\/p>\n

Chiral-phonon-activated spin Seebeck effect.<\/a>
\nKim K, Vetter E, Yan L, Yang C, Wang Z, Sun R, Yang Y, Comstock AH, Li X, Zhou J, Zhang L, You W, Sun D, Liu J.
\nNat Mater. 2023 Mar;22(3):322-328. doi: 10.1038\/s41563-023-01473-9. Epub 2023 Feb 13.
\nPMID:\u00a036781951<\/p>\n

Disordered proteins mitigate the temperature dependence of site-specific binding free energies.<\/a>
\nThole JF, Waudby CA, Pielak GJ.
\nJ Biol Chem. 2023 Mar;299(3):102984. doi: 10.1016\/j.jbc.2023.102984. Epub 2023 Feb 3.
\nPMID:\u00a036739945\u00a0Free PMC article.<\/strong><\/p>\n

Design of a protease-activated PD-L1 inhibitor.<\/a>
\nGoudy OJ, Peng A, Tripathy A, Kuhlman B.
\nProtein Sci. 2023 Mar;32(3):e4578. doi: 10.1002\/pro.4578.
\nPMID:\u00a036705186\u00a0Free PMC article.<\/strong><\/p>\n

Curvature sensing as an emergent property of multiscale assembly of septins.<\/a>
\nShi W, Cannon KS, Curtis BN, Edelmaier C, Gladfelter AS, Nazockdast E.
\nProc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2208253120. doi: 10.1073\/pnas.2208253120. Epub 2023 Jan 30.
\nPMID:\u00a036716363\u00a0Free PMC article.<\/strong><\/p>\n

Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones.<\/a>
\nGuffy SL, Pulavarti SVSRK, Harrison J, Fleming D, Szyperski T, Kuhlman B.
\nBiochemistry. 2023 Feb 7;62(3):770-781. doi: 10.1021\/acs.biochem.2c00595. Epub 2023 Jan 12.
\nPMID:\u00a036634348\u00a0Free PMC article.<\/strong><\/p>\n

Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response.<\/a>
\nSimpson JB, Sekela JJ, Carry BS, Beaty V, Patel S, Redinbo MR.
\nGut Microbes. 2023 Jan-Dec;15(1):2203963. doi: 10.1080\/19490976.2023.2203963.
\nPMID:\u00a037122075\u00a0Free PMC article.<\/strong><\/p>\n

Evaluation of acyllysine isostere interactions with the aromatic pocket of the AF9 YEATS domain.<\/a>
\nTravis CR, Francis DY, Williams DC Jr, Waters ML.
\nProtein Sci. 2023 Jan;32(1):e4533. doi: 10.1002\/pro.4533.
\nPMID:\u00a036482045\u00a0Free PMC article.<\/strong><\/p>\n

Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.<\/a>
\nShell DJ, Rectenwald JM, Buttery PH, Johnson RL, Foley CA, Guduru SKR, Uguen M, Rubiano JS, Zhang X, Li F, Norris-Drouin JL, Axtman M, Brian Hardy P, Vedadi M, Frye SV, James LI, Pearce KH.
\nSLAS Discov. 2022 Dec;27(8):428-439. doi: 10.1016\/j.slasd.2022.10.003. Epub 2022 Oct 19.
\nPMID:\u00a036272689<\/p>\n

High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression.<\/a>
\nVeggiani G, Villase\u00f1or R, Martyn GD, Tang JQ, Krone MW, Gu J, Chen C, Waters ML, Pearce KH, Baubec T, Sidhu SS.
\nNat Commun. 2022 Nov 15;13(1):6975. doi: 10.1038\/s41467-022-34269-7.
\nPMID:\u00a036379931\u00a0Free PMC article.<\/strong><\/p>\n

Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome.<\/a>
\nConway JM, Walton WG, Salas-Gonz\u00e1lez I, Law TF, Lindberg CA, Crook LE, Kosina SM, Fitzpatrick CR, Lietzan AD, Northen TR, Jones CD, Finkel OM, Redinbo MR, Dangl JL.
\nNat Microbiol. 2022 Nov;7(11):1817-1833. doi: 10.1038\/s41564-022-01244-3. Epub 2022 Oct 20.
\nPMID:\u00a036266335\u00a0Free PMC article.<\/strong><\/p>\n

Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3.<\/a>
\nLeighton GO, Irvin EM, Kaur P, Liu M, You C, Bhattaram D, Piehler J, Riehn R, Wang H, Pan H, Williams DC Jr.
\nJ Biol Chem. 2022 Oct;298(10):102428. doi: 10.1016\/j.jbc.2022.102428. Epub 2022 Aug 28.
\nPMID:\u00a036037972\u00a0Free PMC article.<\/strong><\/p>\n

RNA-Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction.<\/a>
\nArney JW, Weeks KM.
\nBiochemistry. 2022 Aug 2;61(15):1625-1632. doi: 10.1021\/acs.biochem.2c00177. Epub 2022 Jul 8.
\nPMID:\u00a035802500\u00a0Free PMC article.<\/strong><\/p>\n

AlphaFold accurately predicts distinct conformations based on the oligomeric state of a de novo designed protein.<\/a>
\nCummins MC, Jacobs TM, Teets FD, DiMaio F, Tripathy A, Kuhlman B.
\nProtein Sci. 2022 Jul;31(7):e4368. doi: 10.1002\/pro.4368.
\nPMID:\u00a035762713\u00a0Free PMC article.<\/strong><\/p>\n

A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines.<\/a>
\nPhan TTN, Hvasta MG, Kudlacek ST, Thiono DJ, Tripathy A, Nicely NI, de Silva AM, Kuhlman B.
\nJ Biol Chem. 2022 Jul;298(7):102079. doi: 10.1016\/j.jbc.2022.102079. Epub 2022 May 26.
\nPMID:\u00a035643320\u00a0Free PMC article.<\/strong><\/p>\n

SHAPE-enabled fragment-based ligand discovery for RNA.<\/a>
\nZeller MJ, Favorov O, Li K, Nuthanakanti A, Hussein D, Michaud A, Lafontaine DA, Busan S, Serganov A, Aub\u00e9 J, Weeks KM.
\nProc Natl Acad Sci U S A. 2022 May 17;119(20):e2122660119. doi: 10.1073\/pnas.2122660119. Epub 2022 May 13.
\nPMID:\u00a035561226\u00a0Free PMC article.<\/strong><\/p>\n

Reprogramming CBX8-PRC1 function with a positive allosteric modulator.<\/a>
\nSuh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O.
\nCell Chem Biol. 2022 Apr 21;29(4):555-571.e11. doi: 10.1016\/j.chembiol.2021.10.003. Epub 2021 Oct 28.
\nPMID:\u00a034715055\u00a0Free PMC article.<\/strong><\/p>\n

Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons.<\/a>
\nSun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LI, Wang Y.
\nAdv Sci (Weinh). 2022 Apr;9(10):e2104317. doi: 10.1002\/advs.202104317. Epub 2022 Feb 4.
\nPMID:\u00a035119221\u00a0Free PMC article.<\/strong><\/p>\n

Mapping the Morphological Landscape of Oligomeric Di-block Peptide-Polymer Amphiphiles.<\/a>
\nAllen BP, Wright ZM, Taylor HF, Oweida TJ, Kader-Pinky S, Patteson EF, Bucci KM, Cox CA, Senthilvel AS, Yingling YG, Knight AS.
\nAngew Chem Int Ed Engl. 2022 Mar 28;61(14):e202115547. doi: 10.1002\/anie.202115547. Epub 2022 Jan 27.
\nPMID:\u00a035037351\u00a0Free PMC article.<\/strong><\/p>\n

Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery.<\/a>
\nZeller MJ, Nuthanakanti A, Li K, Aub\u00e9 J, Serganov A, Weeks KM.
\nACS Chem Biol. 2022 Feb 18;17(2):438-448. doi: 10.1021\/acschembio.1c00880. Epub 2022 Jan 21.
\nPMID:\u00a035060698\u00a0Free PMC article.<\/strong><\/p>\n

Comparative Analysis of Sulfonium-\u03c0, Ammonium-\u03c0, and Sulfur-\u03c0 Interactions and Relevance to SAM-Dependent Methyltransferases.<\/a>
\nAlbanese KI, Leaver-Fay A, Treacy JW, Park R, Houk KN, Kuhlman B, Waters ML.
\nJ Am Chem Soc. 2022 Feb 16;144(6):2535-2545. doi: 10.1021\/jacs.1c09902. Epub 2022 Feb 2.
\nPMID:\u00a035108000\u00a0Free PMC article.<\/strong><\/p>\n

Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding.<\/a>
\nKean KM, Baril SA, Lamb KN, Dishman SN, Treacy JW, Houk KN, Brustad EM, James LI, Waters ML.
\nJ Med Chem. 2022 Feb 10;65(3):2646-2655. doi: 10.1021\/acs.jmedchem.1c02049. Epub 2022 Jan 11.
\nPMID:\u00a035014255\u00a0Free PMC article.<\/strong><\/p>\n

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.<\/a>
\nWelsh KA, Bolhuis DL, Nederstigt AE, Boyer J, Temple BRS, Bonacci T, Gu L, Ordureau A, Harper JW, Steimel JP, Zhang Q, Emanuele MJ, Harrison JS, Brown NG.
\nEMBO J. 2022 Feb 1;41(3):e108823. doi: 10.15252\/embj.2021108823. Epub 2021 Dec 23.
\nPMID:\u00a034942047\u00a0Free PMC article.<\/strong><\/p>\n

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins.<\/a>
\nLamb KN, Dishman SN, Waybright JM, Engelberg IA, Rectenwald JM, Norris-Drouin JL, Cholensky SH, Pearce KH, James LI, Frye SV.
\nACS Omega. 2021 Dec 22;7(1):716-732. doi: 10.1021\/acsomega.1c05381. eCollection 2022 Jan 11.
\nPMID:\u00a035036738\u00a0Free PMC article.<\/strong><\/p>\n

Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.<\/a>
\nZhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G.
\nNat Commun. 2022 Jan 10;13(1):136. doi: 10.1038\/s41467-021-27762-y.
\nPMID:\u00a035013263\u00a0Free PMC article.<\/strong><\/p>\n

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.<\/a>
\nSimpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR.
\nGut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080\/19490976.2022.2107289.
\nPMID:\u00a035953888\u00a0Free PMC article.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Designer peptide-DNA cytoskeletons regulate the function of synthetic cells. Daly ML, Nishi K, Klawa SJ, Hinton KY, Gao Y, Freeman R. Nat Chem. 2024 Aug;16(8):1229-1239. doi: 10.1038\/s41557-024-01509-w. Epub 2024 Apr 23. PMID:\u00a038654104\u00a0Free PMC article. Contribution of Electrostatic CH3-\u03c0 Interactions to Recognition of Histone Asymmetric Dimethylarginine by the SPIN1 Triple Tudor Domain. Travis CR, Dumais RG, … Read more<\/a><\/p>\n","protected":false},"author":79258,"featured_media":0,"parent":0,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2250","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/pages\/2250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/users\/79258"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/comments?post=2250"}],"version-history":[{"count":15,"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/pages\/2250\/revisions"}],"predecessor-version":[{"id":5591,"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/pages\/2250\/revisions\/5591"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/csb\/macinfac\/wp-json\/wp\/v2\/media?parent=2250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}