{"id":3825,"date":"2020-09-11T09:25:49","date_gmt":"2020-09-11T13:25:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/corefacilities\/?p=3825"},"modified":"2020-09-11T09:27:21","modified_gmt":"2020-09-11T13:27:21","slug":"cryo-em-core-facility-determines-high-resolution-structure-of-key-dna-sensing-protein","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/corefacilities\/cryo-em-core-facility-determines-high-resolution-structure-of-key-dna-sensing-protein\/","title":{"rendered":"Cryo-EM Core Facility Determines High-Resolution Structure of Key DNA-sensing Protein"},"content":{"rendered":"<p><a href=\"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3822 alignleft\" src=\"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein-300x288.jpg\" alt=\"Cryo-EM Core Facility Determines High-Resolution Structure of Key DNA-sensing Protein\" width=\"300\" height=\"288\" srcset=\"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein-300x288.jpg 300w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein.jpg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, ºÚÁÏÍø-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body\u2019s healthy DNA.<\/p>\n<p>Read more <a href=\"http:\/\/news.unchealthcare.org\/news\/2020\/september\/researchers-reveal-safeguarding-of-a-key-dna-sensor-in-the-innate-immune-system?utm_source=vs-email&amp;utm_medium=email&amp;utm_campaign=37\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, ºÚÁÏÍø-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body\u2019s healthy DNA.<\/p>\n","protected":false},"author":28418,"featured_media":3822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,6],"tags":[18,15,16,17],"class_list":["post-3825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-spotlight","tag-cryoem-core-facility","tag-qi-zhang","tag-robert-mcginty","tag-unc-lineberger-comprehensive-cancer-center","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein-300x288.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2019\/01\/Cryo-EM-Core-Facility-Determines-High-Resolution-Structure-of-Key-DNA-sensing-Protein-150x150.jpg","featured_image_alt":"Cryo-EM Core Facility Determines High-Resolution Structure of Key DNA-sensing Protein","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/corefacilities\/category\/news\/"},{"name":"Spotlight","link":"https:\/\/www.med.unc.edu\/corefacilities\/category\/spotlight\/"}],"tag_details":[{"name":"CryoEM Core Facility","link":"https:\/\/www.med.unc.edu\/corefacilities\/tag\/cryoem-core-facility\/"},{"name":"Qi Zhang","link":"https:\/\/www.med.unc.edu\/corefacilities\/tag\/qi-zhang\/"},{"name":"Robert McGinty","link":"https:\/\/www.med.unc.edu\/corefacilities\/tag\/robert-mcginty\/"},{"name":"ºÚÁÏÍø Lineberger Comprehensive Cancer Center.","link":"https:\/\/www.med.unc.edu\/corefacilities\/tag\/unc-lineberger-comprehensive-cancer-center\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/posts\/3825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/users\/28418"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/comments?post=3825"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/posts\/3825\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/media\/3822"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/media?parent=3825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/categories?post=3825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/tags?post=3825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}