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[(\))-449.4(Tidal)-442.5(volume)-448.5(breathing)-449.7(of)-452.2(5-)]TJ /F7 1 Tf 14.0432 0 TD (m)Tj /F6 1 Tf .5501 0 TD [(m)-446.5(aerosol,)-449.7(0.44-L)-447.5(inhalation)-453(at)-442.6(0.48)-165.9(Lps)-448.3(cyclic)-451.9(mean)-449.3(ow,)-446.6(35%)-443.3(extrathoracic)]TJ -19.9172 -1.1128 TD [(deposition;)-423.3(\()]TJ /F10 1 Tf 5.6147 0 TD (b)Tj /F6 1 Tf .6007 0 TD [(\))-417.8(Large)-418.5(9.5-)]TJ /F7 1 Tf 5.2354 0 TD (m)Tj /F6 1 Tf .5564 0 TD [(m)-408.6(particle,)-422.2(extremely)-419.5(slow)-413.9(inhalation,)-418(0.80-L)-415.9(inhalation)-415.1(at)-417.3(0.080)-165.4(Lps)-416.7(constant)-421.6(ow,)-415(21%)-411.6(extra-)]TJ -12.0072 -1.1128 TD [(thoracic)-438.9(deposition.)-435.9(ROIs)-428(indicate)-436.3(location)-432.6(of)-433.2(right)-429.8(lung.)-432.9(Images)-434.8(have)-433.5(been)-431.2(gray-scaled)-433.4(to)-433.2(same)-428.2(number)-437.3(of)-433.2(total)-430.4(counts)]TJ T* [(\(Subject)-338.1(41019\).)]TJ ET 310.847 268.951 239.074 .22678 re f 310.847 113.896 239.074 .28348 re f 310.847 249.959 239.074 .22676 re f 310.847 191.339 239.074 .22675 re f 310.847 162.595 239.074 .22682 re f BT /F11 1 Tf 8.9663 0 0 8.9663 331.2566 304.4976 Tm (Table)Tj /F6 1 Tf 3.0603 0 TD (1.)Tj /F11 1 Tf 1.2519 0 TD [(The)-331.9(Regional)-335.1(Deposition)-337.8(of)-336.4(Inhaled)]TJ -5.052 -1.1128 TD [(Particles)-336.2(Using)-331.9(the)-338.4(Extremely)-332.7(Slow)-335.5(Inhalation)]TJ .8789 -1.1065 TD (of)Tj /F6 1 Tf 1.3974 0 TD (9.5)Tj /F11 1 Tf 1.2519 0 TD (-)Tj /F7 1 Tf .3288 0 TD (m)Tj /F11 1 Tf .5564 0 TD [(m)-331.8(Particles)-336.2(\()]TJ /F6 1 Tf 6.3798 0 TD (ESI-9)Tj /F11 1 Tf 2.2826 0 TD [(\))-337.2(and)-331.7(Tidal)-334.7(Volume)]TJ -10.0724 -1.1128 TD [(Breathing)-339.6(of)]TJ /F6 1 Tf 6.7276 0 TD (5)Tj /F11 1 Tf .4995 0 TD (-)Tj /F7 1 Tf .3351 0 TD (m)Tj /F11 1 Tf .5501 0 TD [(m)-338.2(Particles)-329.9(\()]TJ /F6 1 Tf 6.3861 0 TD (TVB-5)Tj /F11 1 Tf 2.7505 0 TD (\))Tj /F9 1 Tf -21.7887 -2.0423 TD [(Percent)-331.1(of)-336.3(total)-336.5(deposition)-1771.7(ESI-9)-1772(\(SD\))-1770.9(TVB-5)-1772.9(\(SD\))]TJ /F6 1 Tf 0 -2.0992 TD (Lungs)Tj 6.7246 0 0 5.9768 335.3952 241.5117 Tm (a)Tj 8.9663 0 0 8.9663 424.233 237.4866 Tm [(75)-2831.7(\(7\))-3054.4(64)-3059.3(\(11\))]TJ -12.6458 -1.1065 TD [(%)-330.4(CAD)]TJ 6.7246 0 0 5.9768 341.4613 231.5338 Tm (b)Tj 8.9663 0 0 8.9663 424.233 227.5653 Tm [(35)-2831.7(\(8\))-3054.4(27)-3059.3(\(11\))]TJ -12.6458 -1.1128 TD [(Large)-330(airways)]TJ 6.7246 0 0 5.9768 367.4267 221.5559 Tm (c)Tj 8.9663 0 0 8.9663 424.233 217.5873 Tm [(15)-2831.7(\(8\))-3553.9(9)-3059.8(\(7\))]TJ -12.6458 -1.1128 TD [(Alveolar)-334.6(deposition)]TJ 6.7246 0 0 5.9768 389.2534 211.5779 Tm (a)Tj 8.9663 0 0 8.9663 424.233 207.6094 Tm [(35)-2831.7(\(3\))-3054.4(54)-3059.3(\(9\))]TJ -12.6458 -1.1128 TD (Extrathoracic)Tj 6.7246 0 0 5.9768 362.8345 201.6566 Tm (a)Tj 8.9663 0 0 8.9663 424.233 197.6315 Tm [(26)-2831.7(\(7\))-3054.4(37)-3059.3(\(11\))]TJ /F9 1 Tf -12.6458 -2.0929 TD [(Percent)-331.1(of)-336.3(deposition)]TJ 0 -1.1128 TD [(in)-335.1(the)-329.5(lungs)-7415.1(ESI-9)-1772(\(SD\))-1770.9(TVB-5)-1772.9(\(SD\))]TJ /F6 1 Tf 0 -2.0929 TD [(large)-330.5(airways)]TJ 6.7246 0 0 5.9768 364.5353 154.0913 Tm (d)Tj 8.9663 0 0 8.9663 424.233 150.1228 Tm [(20)-2831.7(\(10\))-2554.4(13)-3059.3(\(11\))]TJ -12.6458 -1.1128 TD [(In)-334.3(central)-335.6(ROI)]TJ 6.7246 0 0 5.9768 367.54 144.17 Tm (a)Tj 8.9663 0 0 8.9663 424.233 140.1448 Tm [(40)-2831.7(\(5\))-3054.4(31)-3059.3(\(6\))]TJ -12.6458 -1.1065 TD [(Alveolar)-334.6(n.s.)-7035.3(53)-2831.7(\(10\))-2554.4(59)-3059.3(\(14\))]TJ 0 -1.1128 TD (C)Tj /F12 1 Tf .7082 0 TD (=)Tj /F6 1 Tf .4995 0 TD [(P)-330.1(right)-341.3(lung)]TJ 6.7246 0 0 5.9768 369.8645 124.2141 Tm (e)Tj 8.9663 0 0 8.9663 428.7117 120.2456 Tm [(1.9)-2082.2(\(0.3\))-2803.9(1.6)-2309.8(\(0.4\))]TJ 7.9702 0 0 7.9702 318.7841 102.1039 Tm [(Differences)-390.3(between)-385.7(ESI-9)-381.3(and)-386.8(TVB-5)-388.9(are)-389.7(evaluated)-382.5(by)-389.8(paired)]TJ /F9 1 Tf 28.3601 0 TD (t)Tj /F6 1 Tf .3201 0 TD (-)Tj -29.676 -1.1239 TD (test.)Tj 5.9774 0 0 5.3127 318.7841 87.7039 Tm (a)Tj /F9 1 Tf 7.9702 0 0 7.9702 321.7889 84.189 Tm (p)Tj /F12 1 Tf .6615 0 TD (<)Tj /F6 1 Tf .9389 0 TD (0.001,)Tj 5.9774 0 0 5.3127 360.6235 87.7039 Tm (b)Tj /F9 1 Tf 7.9702 0 0 7.9702 363.9117 84.189 Tm (p)Tj /F8 1 Tf .6686 0 TD ()Tj /F6 1 Tf .9318 0 TD (0.004,)Tj 5.9774 0 0 5.3127 402.803 87.7039 Tm (c)Tj /F9 1 Tf 7.9702 0 0 7.9702 405.4109 84.189 Tm (p)Tj /F8 1 Tf .6615 0 TD ()Tj /F6 1 Tf .9389 0 TD (0.009,)Tj 5.9774 0 0 5.3127 444.2455 87.7039 Tm (d)Tj /F9 1 Tf 7.9702 0 0 7.9702 447.8739 84.189 Tm (p)Tj /F8 1 Tf .6615 0 TD ()Tj /F6 1 Tf .9389 0 TD (0.04,)Tj 5.9774 0 0 5.3127 482.74 87.7039 Tm (e)Tj /F9 1 Tf 7.9702 0 0 7.9702 485.518 84.189 Tm (p)Tj /F8 1 Tf .6686 0 TD ()Tj /F6 1 Tf .9318 0 TD [(0.02,)-781.3(n.s.)-781.1(not)]TJ -23.516 -1.1239 TD [(signican)11.1(t.)-480.7(C)]TJ /F12 1 Tf 5.9608 0 TD (=)Tj /F6 1 Tf .4979 0 TD [(P)-481.1(i)0(s)-476.7(planar)-476.6(analysis)-472.5(of)-474.3(deposition)-474(in)-477.2(central)-470.7(region)]TJ -6.4587 -1.131 TD [(compared)-320.1(to)-332(the)-330.9(peripheral)-332.3(region.)]TJ .9958 -1.1239 TD [(CAD,)-333(conduc)11.5(ting)-335.8(airway)-320.6(deposition;)-330.7(ROI,)-324.5(region)-330.8(of)-332(interest.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(TARGETTING)-342.7(AEROSOLS)-333.6(TO)-331.2(THE)-335.2(AIRWAYS)]TJ 54.1178 0 TD (5)Tj ET endstream endobj 70 0 obj <>stream AdobedC        s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?c\ef͛6lٳf͏sx%](foa4r9d;VQ:C^ox\K 3D G_+\Ɩ8ٹn;76lٳf͛6zpk/wzW͟k?s&[+spʯcH͛6lٳf͛[)m WrWEl1׶[t_Mө铏5?Ecrg䣤Y]hscv~yueS;bi$][!Y_7\'ʦV]Nlٳf͛6lW6_?Lxp&.?eueg9,o4۸m5+۽Uż2GC5~ zYJQ [sFs,ٳf͛6lٳfiJ0OTEM&J6 oX|2_\jzM֝ui=L6n% WgYM.ٳf͛6lٳf͛6 > )E&*ȆpA9ɨkeV?E!cE7T!io|ת_QdX4bO'͛6lٳf͛1ݱRRS a~-egʽIvd#s$-; :)P#)RN[m>I  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[(7.)-501.9(A)13.5(n)16.3(d)14.9(e)12.8(r)16.8(s)14.3(on)-473.7(M)13.1(,)-479.7(P)17.3(h)0(i)22.8(l)19.9(i)13.2(p)0(s)24.9(o)18.8(n)-485.8(K)15(,)-486.4(S)17.9(v)13(a)0(r)28.1(t)14(e)12.8(n)16.3(g)16.4(r)0(e)29.5(n)-485.8(M)13.1(,)-479.7(an)27.6(d)-487.2(C)18.4(am)29.4(ne)29.1(r)-485.3(P)0(:)]TJ 1.2519 -1.2385 TD [(Hu)29.2(m)18.1(a)0(n)-153.1(d)14.9(e)12.8(p)0(o)29.4(s)14.3(i)13.2(t)14(i)13.2(o)0(n)-152.3(a)18(nd)-156.3(c)15.2(l)13.2(e)19.4(a)0(r)28.1(a)0(n)27.6(c)15.2(e)-168(o)0(f)-154.6(6)18(-)]TJ /F7 1 Tf 15.8466 0 TD (m)Tj /F6 1 Tf .5356 0 TD -.0143 Tc [(m)-183.7(p)2.9(a)-14.3(r)13.8(ticles)-180.7(inha)-14.3(l)16.9(e)-1.5(d)-180.2(w)-14.3(i)15.1(t)-.3(h)]TJ -16.3821 -1.2318 TD 0 Tc [(a)18(n)-264.8(e)12.8(x)14.6(t)14(r)0(e)29.5(m)0(e)24.1(l)19.9(y)-271.5(l)19.9(ow)-252.8()14.9(o)0(w)-252.8(r)16.8(at)25.3(e)19.5(.)-265.5(E)14.9(x)14.6(p.)-254.9(L)14.9(u)17.3(ng)-255.1(R)16.6(e)12.8(s)14.3(.)-265.5(1)18(9)0(9)29.3(5)0(;)27(2)18(1:)27(1)18(8)0(7)29.3()0(1)29.3(9)18(5.)]TJ -1.2519 -1.2385 TD [(8.)-501.9(Anderson)-586(M,)-580.4(Svartengren)-585.4(M,)-580.4(Dahlba)]TJ 18.3303 .0134 TD ()Tj .4352 -.0134 TD [(ck)-584.3(M,)-580.4(Nerbrink)-582.3(O,)]TJ -17.5136 -1.2318 TD [(Philipson)-469.3(K,)-458(and)-466.3(Camner)-462(P:)-462.5(Human)-467.4(tracheobronchial)-466.9(de-)]TJ 0 -1.2385 TD [(position)-469.9(and)-459.6(effect)-466.1(of)-469.3(two)-459.7(cholinergic)-468.5(aerosols.)-473.3(Exp)-462.1(Lung)]TJ 0 -1.2318 TD [(Res.)-335.6(1993;19:653669.)]TJ -1.2519 -1.2385 TD [(9.)-501.9(Anderson)-445.4(M,)-446.5(Svartengren)-444.8(M,)-446.5(and)-439.6(Camner)-441.9(P:)-442.4(Huma)-8.4(n)-438.9(tra-)]TJ 1.2519 -1.2318 TD [(cheobronchial)-421.9(deposition)-422.2(and)-412.8(effect)-419.3(of)-415.7(a)-410.5(histamine)-419.5(aerosol)]TJ 0 -1.2385 TD [(inhaled)-297(by)-295.2(extremely)-297.1(slow)-299(inhalations.)-301.3(J)-293.9(Aerosol)-300.2(Med.)-298.4(1999;)]TJ 0 -1.2318 TD (30:289297.)Tj 27.8972 78.8846 TD [(10.)-497.3(Camner)-361.6(P,)-355.4(Anderson)-358.4(M,)-352.8(Philipson)-362.2(K,)-357.6(Bailey)-353.4(A,)-352.4(Hashish)-364.2(A,)]TJ 1.7473 -1.2318 TD [(Jarvis)-345.8(N,)-340.6(Bailey)-340.1(M,)-339.4(and)-345.8(Svartengren)-344.4(M:)-339.4(human)-349.2(bronchiolar)]TJ 0 -1.2385 TD [(deposition)-295(and)-292.3(rentention)-290.5(of)-288.5(6-,)-293.7(8-,)-287(and)-285.6(10-)]TJ /F7 1 Tf 18.8391 0 TD (m)Tj /F6 1 Tf .549 0 TD [(m)-289.9(particles.)-291.4(Exp)]TJ -19.3881 -1.2318 TD [(Lung)-336.8(Res.)-335.6(1997;23:517535.)]TJ -1.7473 -1.2385 TD [(11.)-497.3(Falk)-297.5(R,)-302.5(Philipson)-302(K,)-297.3(Svartengr)-12(en)-299(M,)-299.2(Jarvis)-299(N,)-300.4(Bailey)-299.9(M,)-299.2(and)]TJ 1.7473 -1.2318 TD [(Camner)-241.1(P:)-234.9(Clearance)-240.2(of)-234.9(particles)-240.2(from)-233.6(small)-237.9(ciliated)-240.4(airways.)]TJ 0 -1.2385 TD [(Exp)-334.9(Lung)-336.8(Res.)-335.6(1997;23:495515.)]TJ -1.7473 -1.2318 TD [(12.)-497.3(Lindstrom)-334.1(M,)-332.7(Camner)-334.8(P,)-328.6(Falk)-331(R,)-335.9(Hjelte)-335.6(L,)-331(Philipson)-335.4(K,)-330.8(and)]TJ 1.7473 -1.2385 TD [(Svartengren)-364.5(M:)-352.8(Long-term)-360(clearance)-357.2(from)-360.8(small)-358.4(airways)-355.7(in)]TJ 0 -1.2318 TD [(patients)-342(with)-335.2(cystic)-333.3(brosis.)-337.6(Exp)-334.9(Respir)-337.6(J.)-338.5(2005;25:317323.)]TJ -1.7473 -1.2385 TD [(13.)-497.3(Bennett)-334.1(WD,)-323.2(Brown)-332.1(JS,)-327.3(Zeman)-326.7(KL,)-322.6(Hu)-332.3(SC,)-322.9(Scheuch)-330.9(G,)-329(and)]TJ 1.7473 -1.2318 TD [(Sommerer)-269.8(K:)-263.8(Targeting)-269.6(delivery)-268.6(of)-268.4(aerosols)-268(to)-268.4(different)-272.9(lung)]TJ 0 -1.2385 TD [(regions.)-337.7(J)-334.1(Aerosol)-340.4(Med.)-331.9(2002;15:179188.)]TJ -1.7473 -1.2318 TD [(14.)-497.3(Lay)-312.3(JC,)-313.4(Clifford)-311.8(BR,)-314.4(Kim)-308.5(SC,)-316.2(and)-312.4(Bennett)-314(WD:)-309.8(Retention)-320.4(of)]TJ 1.7473 -1.2385 TD [(insoluble)-520.6(particles)-521.3(after)-520.2(local)-517.4(intrabronchial)-527.2(deposition)-522.6(in)]TJ 0 -1.2318 TD [(dogs.)-335(J)-334.1(Appl)-340.5(Physiol.)-336.7(1995;79:19211929.)]TJ -1.7473 -1.2385 TD [(15.)-497.3(Pitcairn)-257.6(GR,)-245.4(and)-252.1(Newman)-254.8(SP:)-250.5(Tissue)-248.1(attenuation)-255.7(correct)-10.9(ions)]TJ 1.7473 -1.2318 TD [(in)-338.7(gamma)-333.3(scintigraphy.)-339.1(J)-334.1(Aerosol)-340.4(Med.)-331.9(1997;10:187198.)]TJ -1.7473 -1.2385 TD [(16.)-497.3(Lippmann)-337.4(M,)-339.4(Yeates)-333.3(DB,)-337.6(and)-332.4(Albert)-341.8(RE:)-334.5(Deposition,)-340.9(reten-)]TJ 1.7473 -1.2385 TD [(tion)-506.7(and)-506.5(clearance)-511.2(of)-502.7(inhaled)-504.6(particles.)-512.4(Br)-503.9(J)-501.5(Indust)-514.1(Med.)]TJ 0 -1.2318 TD (1980;37:337362.)Tj -1.7473 -1.2385 TD [(17.)-497.3(Stahlhofen)-458.2(W,)-450.5(Gebhart)-457.9(J,)-452.3(and)-452.9(Heyder)-450.1(J:)-452.3(Experimental)-460.9(de-)]TJ 1.7473 -1.2318 TD [(termination)-471.2(of)-462.6(the)-465.7(regional)-463.7(deposition)-469.1(of)-462.6(aerosol)-463.1(particles)]TJ 0 -1.2385 TD [(in)-459.2(the)-465.7(human)-456.3(respiratory)-467.6(tract.)-461.9(Am)-457.2(Ind)-466(Hyg)-457.4(Ass)-460(J.)-459(1980;)]TJ 0 -1.2318 TD (41:385398.)Tj -1.7473 -1.2385 TD [(18.)-497.3(Bennett)-374.2(WD,)-370(Scheuch)-377.7(G,)-369.1(and)-365.9(Zeman)-373.5(KL:)-369.5(Bronchial)-372.8(airway)]TJ 1.7473 -1.2318 TD [(deposition)-281.6(and)-272.2(retention)-273.3(of)-275.1(particles)-273.6(in)-278.4(inhaled)-270.3(boli:)-277.5(effect)-272(of)]TJ 0 -1.2385 TD [(anatomic)-337(dead)-334.6(space.)-335.3(J)-334.1(Appl)-340.5(Physiol.)-336.7(1998;85:685694.)]TJ -1.7473 -1.2318 TD [(19.)-497.3(Knudson)-429.4(RJ,)-429(Burrows)-427.3(B,)-424.7(and)-426.2(Lebowitz)-431.4(MD:)-426.4(The)-424.7(maximal)]TJ 1.7473 -1.2385 TD [(expiratory)-510.9(ow-volume)-505.8(curve:)-505.1(its)-500.7(use)-504.7(in)-506(the)-505.8(detection)-504(of)]TJ 0 -1.2318 TD [(ventilatory)-502.9(abnormalities)-499.9(in)-492.6(a)-490.8(population)-498.7(study.)-496.6(Am)-497.3(Rev)]TJ 0 -1.2385 TD [(Respir)-337.6(Dis.)-338.3(1976;114:871879.)]TJ -1.7473 -1.2318 TD [(20.)-497.3(Usmani)-375.3(OS,)-377.1(Biddiscombe)-375.7(MF,)-369.9(Nightingale)-380.5(JA,)-371.9(Underwood)]TJ 1.7473 -1.2385 TD [(SR.)-358.2(and)-352.5(Barnes)-355.5(PJ:)-354.7(Effects)-362.7(of)-355.5(bronchodilator)-361.6(particle)-354.9(size)-356.8(in)]TJ 0 -1.2318 TD [(asthmatic)-642.1(patients)-643.3(using)-645.5(monodisperse)-641.9(aerosols.)-640.7(J)-642.1(Appl)]TJ 0 -1.2385 TD [(Physiol.)-336.7(2003;95:21062112)-7(.)]TJ -1.7473 -1.2318 TD [(21.)-497.3(Weda)-434(M,)-426.4(Zanen)-435.5(P,)-429(deBoer)-431.4(AH,)-427.5(Barends)-434.4(DM,)-426.4(and)-432.9(Frijlink)]TJ 1.7473 -1.2385 TD [(HW:)-251.1(The)-243.9(therapeutic)-260.9(index)-249.6(of)-248.3(locally)-246.8(acting)-248.2(inhaled)-250.2(drugs)-248.4(as)]TJ 0 -1.2318 TD [(a)-310.1(function)-316.6(of)-308.6(their)-315.2(ne)-310.9(particle)-308(mass)-310.2(and)-312.4(particle)-314.7(size)-310(distri-)]TJ 0 -1.2385 TD [(butiona)-191.5(literature)-192.7(review.)-187.4(Curr)-191.8(Drug)-183.8(Deliv.)-193.1(2008;5:142147.)]TJ -1.7473 -1.2318 TD [(22.)-497.3(Clark)-285.4(AR,)-289(Chambers)-290.7(CB,)-285.8(Muir)-287.8(D,)-285.5(Newhouse)-294.7(MT,)-284.4(Paboojian)]TJ 1.7473 -1.2385 TD [(S,)-254.3(and)-245.4(Schuler)-258.8(C:)-247.1(The)-250.6(effect)-258.6(of)-248.3(biphasic)-251(inhalation)-257.7(proles)-253.6(on)]TJ 0 -1.2318 TD [(the)-405.4(deposition)-408.8(and)-406.1(clearance)-404.1(of)-409(coarse)-406.3(\(6.5)]TJ /F7 1 Tf 19.3278 0 TD (m)Tj /F6 1 Tf .549 0 TD [(m\))-403.1(bolus)-408.7(aero-)]TJ -19.8768 -1.2385 TD [(sols.)-338.8(J)-334.1(Aerosol)-333.7(Med.)-338.6(2007;20:7582.)]TJ -1.7473 -1.2318 TD [(23.)-497.3(Smith)-690.4(JRH,)-684.9(Bailey)-681.5(MR,)-684.3(Etherington)-693.7(G,)-677.1(Shutt)-690.4(AL,)-685.7(and)]TJ 1.7473 -1.2385 TD [(Youngman)-337.6(MJ:)-325.4(Effect)-336.8(of)-328.7(particle)-334.8(size)-330.1(on)-333.1(slow)-332.4(particle)-328.1(clear-)]TJ 0 -1.2318 TD [(ance)-245.7(from)-240.3(the)-238.1(bronchial)-244(tree.)-242.6(Exp)-241.2(Lung)-236.4(Res.)-241.9(2008;34:287312.)]TJ 8.9663 0 0 8.9663 460.2329 225.2975 Tm [(Received)-282.4(June)-283.3(17,)-280.2(2008)]TJ -2.6619 -1.2203 TD [(in)-278.8(nal)-281.3(form,)-282.6(March)-279.9(23,)-280.2(2010)]TJ 6.6264 -2.8011 TD [(Reviewed)-335.3(by:)]TJ -.4995 -1.2203 TD [(Kurt)-334.1(Nikander)]TJ -.5944 -1.2266 TD [(Paula)-334.1(Anderson)]TJ -.1328 -1.2203 TD [(Myrna)-329.3(Dolovich)]TJ -5.0773 -2.8011 TD [(Address)-339.4(correspondence)-340.1(to:)]TJ /F9 1 Tf 2.8263 -1.2203 TD [(Kirby)-332.4(L.)-336.1(Zeman,)-335.4(Ph.D.)]TJ -5.0204 -1.2203 TD [(Center)-333.7(for)-337(Environmental)-337.5(Medicine)]TJ 3.7368 -1.2266 TD [(Asthma)-339.3(and)-332(Lung)-335.2(Biology)]TJ -3.3195 -1.2203 TD [(104)-333.6(Mason)-331.3(Farm)-334.6(Road,)-334(CB)-336(#7310)]TJ 4.5904 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