黑料网

B. Positions and Honors

1991 Thomas Davis Fellowship Award, NC Chapter of American Lung Association

1991-1995 Research Assistant Professor of Pediatrics, University of North Carolina at Chapel Hill

1995-2001 Assistant Professor of Pediatrics, University of North Carolina at Chapel Hill

1991-present Investigator, University of North Carolina Center for Environmental Medicine,

Asthma and Lung Biology (CEMALB)

1998-2005 Director, 黑料网 Pediatric Pulmonology Fellowship Training Program

1999 Society for Pediatric Research

2000 Jefferson-Pilot Fellowship Award, University of North Carolina at Chapel Hill

2000 NIH Study Section (Lung Biology and Pathology) ad hoc reviewer

2001-2007 Associate Professor of Pediatrics, University of North Carolina at Chapel Hill

2002-2009 Chief, Pediatric Pulmonology Division, University of North Carolina at Chapel Hill

2002-2007 黑料网 Hospitals Graduate Medical Education Committee

2003-2007 黑料网 K30 Clinical Research Curriculum Award Internal Advisory Committee

2005-present Best Doctors in America^脱

2007-present Professor of Pediatrics, University of North Carolina at Chapel Hill

2008 NC Children’s Hospital James Emonson Faculty Honour

2007-2009 NIEHS Institutional Review Board

2009 NIH Special Emphasis Panel ZRG1DIGB50R (NARCH program)

2009 NIH Study Section (Lung Cellular Molecular Immunobiology) ad hoc reviewer

2010 NIH Special Emphasis Panel ZRG1 CVRS-H (11) – (Respiratory Sciences Small Business Activities)

2011-present Vice Chair for Faculty Development, 黑料网 Department of Pediatrics

2012-present 黑料网 Biomedical Institutional Review Board Scientific Review Subcommittee

2013 NIH Study Section (Lung Cellular Molecular Immunobiology) ad hoc reviewer

2013-present Deputy Editor, Pediatric Pulmonology

C. Selected peer-reviewed publications (15 recent)

1. 1. Noah TL, Zhang H, Zhou H, Glista-Baker E, Muller L, Bauer RN, Meyer M, Murphy PC, Jones S, Letang B, Robinette C, Herbst M, Jaspers I. Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers. PLOS ONE 2014 EMID:a68cc3feb754479a. (in press)
2. Muller L, Chehrazi CVE, Henderson MW, Noah TL, Jaspers I. Diesel exhaust particles modify Natural Killer cell function and cytokine release. Particle and Fiber Toxicology 2013;10:16 doi:10.1186/1743-8977-10-16.
3. Jones S, Zhou H, Herbst M, Ortiz-Pujols S, Maile R, Joyner, Jr BL, Zhang H, Kesic M, Jaspers I, Short KA, Meyer M, Peden DB*, Cairns BA*, Noah TL*. Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study. PLOS ONE 2013. May 17;8(5):e64250. doi: 10.1371/journal.pone.0064250.* = co-senior authors.
4. Paich H, Sheridan P, Handy J, Hudgens M, Noah T, Weir S, Beck M. Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus. Obesity (Silver Spring). 2013 Mar 20. [Epub ahead of print] PMID: 23512822
5. Meyer M, Kesic M, Clark J, Ho E, Diaz-Sanchez, Noah TL, Jaspers I. Nutritional activation of Nrf2 enhances secretory leukoprotease inhibitor in the nasal mucosa. Respiratory Medicine 2013 Mar;107(3):472-5. Epub 2012 Nov 26. PMID: 23195333
6. Joyner BL, Harris BD, Coverstone AM, Jones SW, Abode KA, Kocis KC, Cairns BA, Noah TL. DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries. J Burn Care Res 2012 2012 Nov 6. [Epub ahead of print] PMID: 23128126
7. Kansagra S, D鈥機ruz O, Noah TL, Vaughn BV. Sleep-Disordered Breathing in Beckwith-Wiedemann Syndrome: Three Patients. Am J Med Genetics 2012 Nov;158A(11):2956-8. Epub 2012 Sep 14. PMID:22987607
8. Noah TL, Zhou H, Zhang H, Horvath K, Robinette C, Kesic M, Meyer M, Diaz-Sanchez D, Jaspers I. Diesel exhaust exposure and nasal response to attenuated influenza virus in normal and allergic volunteers. Am J Resp Crit Care Med 2012;185:179-185.
9. Horvath KM, Brighton LE, Herbst M, Noah TL, Jasper I. Live Attenuated Influenza Virus (LAIV) Induces Different Mucosal T Cell Function In Nonsmokers And Smokers. Clin Immunol 2012 Mar;142(3):232-6.
10. Joyner BL, Harris BD, Coverstone AM, Jones SW, Abode KA, Kocis KC, Cairns BA, Noah TL. DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries. J Burn Care Res 2012 (in press).
11. Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon A., Holland L, Weir S, Noah TL, Beck MA. Obesity is associated with impaired immune response to influenza vaccination in humans. 2011 Int J Obesity (Lond) Oct 25. doi: 10.1038/ijo.2011.208.
12. Harris WT, Muhlebach MS, Oster RA, Knowles MR, Clancy JP, Noah TL. Plasma TGF-尾1 in pediatric cystic fibrosis: potential biomarker of lung disease and response to therapy. Pediatr Pulmonol 2010 Epub ahead of print DOI 10.1002/ppul.21430.
13. 14. Noah TL, Zhou H, Monaco J, Horvath K, Herbst M, Jaspers I. Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus. Environ Health Perspect. 2011 Oct 4. [Epub ahead of print] PMID: 20920950
14. Jaspers I, Horvath KM, Zheng W, Brighton LE, Carson JL, Noah TL. Reduced expression of IRF7 in nasal epitheial cells from smokers after infection with influenza. Am J Resp Cell Mol Biol 2009 (PMID: 19880818).
15. Horvath KM, Herbst M, Zhou H, Zhang H, Noah TL, Jaspers I. Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus. Resp Res 2011;12:102.

 

D. Research Support (past 3 years)

Completed Research support

FAMRI 082376 Jaspers (PI) 7/1/2009-6/30/2012

SHS and Influenza-induced immune responses

The purpose of this grant is to investigate the effects of passive tobacco smoke on nasal immune responses.

Role: Co-Investigator

Ongoing Research support

US EPA CR83346301 Peden (PI) 07/01/2007 – 01/31/2015

Human Health Effects of Environmental Pollutants

This is a cooperative agreement between the US EPA and 黑料网 to provide scientific and medical expertise relevant to EPA鈥檚 human research studies on pollutant effects.

Role: Co-Investigator

NIH R01 AI078090 Beck (PI) 12/1/2008-11/30/2011 (renewed 2012)

Risk of Influenza in a vaccinated obese population

The purpose of this project is to assess the impact of obesity on immune responses to influenza vaccine. No overlap with current proposal which studies children only.

Role: Co-Investigator

 

NIH R01 HL095163 Noah, Jaspers (PI’s) 7/1/2009-6/30/2014

Cigarette Smoke and Susceptibility to Influenza Infections

The purpose of this project is to investigate the effects of tobacco smoke exposure on epithelial antiviral and inflammatory pathways.

Role: PI (multiple)

NIH R01 ES013611 Jaspers, Noah (PI’s) 7/1/2010-6/30/2015

Diesel-Induced Alterations of Influenza Infectivity

The purpose of this project is to investigate the effects of diesel exhaust particle exposure on epithelial antiviral and inflammatory pathways in the setting of influenza.

Role: PI (multiple)

NIH 3R01ES013611-07S1 Jaspers (PI) 11/1/2012-6/30/2015

Diesel-induced Alterations of Influenza Infectivity (ViCTER)

Using a transdisciplinary research team, this ViCTER program based on R01 ES013611 aims to develop novel translational research tools to investigate mechanisms by which exposure to pollutant affects respiratory innate immune responses.

Role: Co-I

FAMRI CIA 12 #123009 Jaspers (PI) 7/1/13-6/30/16

Cigarette Smoke, Viral infections and NK Cells

Purpose: to increase the mechanistic understanding of the effects of CS exposure on nasal mucosal immune responses, focusing on the potential roles of epithelial cells and NK cells, and explore potential therapeutic interventions.

Role: Co-I

NIH 2 T32 HL007106-36 Doerschuk (PI) 4/1/2012-3/31/201

Multidisciplinary Research Training in Pulmonary Diseases

This Training Program supports six postdoctoral trainees with M.D., M.D./Ph.D. or Ph.D. degrees to pursue research training in Respiratory Medicine, emphasizing a joint training program for Medicine and Pediatric trainees. The Program provides multidisciplinary training in basic, translation and clinical research within the pulmonary divisions of the Departments of Medicine and Pediatrics and the three centers devoted to understanding lung health and disease.

Role: Co-I