neuroscience Archives - Department of Cell Biology and Physiology

A fluorescence microscope image of the coronal section of the hippocampus in the adult mouse brain with NLRP1 expression removed

Trimming neuronal axons involves a distinct pathway and a rare pathogen-sensing immune protein that could have implications for Alzheimer鈥檚 disease. Neurons have the remarkable ability to kill parts of themselves without dying in a phenomenon known as axon pruning. During axon pruning, neurons trim unnecessary axons, long, threadlike projections from nerve cells that transmit electrical …

Structure of mHCAD chemogenetic system in complex with FCH-2296413 (magenta), an inert drug-like compound. Credit: Kang et. al (2024).

Using technology first designed by Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology, researchers at the 黑料网 have engineered a molecular technology that can turn off pain receptors. Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a …

More information on speaker聽 Kristy Welshhans received her Bachelor of Arts degree in biology from Agnes Scott College and her PhD in neurobiology and behavior from Georgia State University. She received a National Institute of Health postdoctoral fellowship for work examining the role of mRNA binding proteins during axon guidance while in the laboratory …

This photo shows p-c-Jun staining in neurons undergoing apoptosis. The green signal indicates p-c-Jun (a marker of apoptotic signaling). The blue signal indicates cell nuclei. The red signal indicates alpha-tubulin, which is a cytoskeletal protein.

Neurons are among the few cells that can halt cell death and recover from apoptosis. Now scientists know why. 鈥淣eurons can reverse their decision to die from a point that鈥檚 considered impossible in most other cells,鈥� said Mohanish Deshmukh, a neuroscientist in the Department of Cell Biology and Physiology. In a recent study published in …

An illustration of the three pillars of health depicting sleep together with diet and exercise upholding human health. This is original art from one of my first lab members Sarah Monroe.

Sleep disturbances during early development alter key synaptic proteins involved in autism spectrum disorder. Anyone who has ever put a toddler to bed knows it鈥檚 a struggle. While sleep might be the bane of a toddler鈥檚 existence it is also an essential component for their brain development. Toddlers need an average of 11-14 hours of …

Led by Greg Scherrer, PharmD, PhD, and Chong Chen, MD, PhD, at the 黑料网, research published in Nature reveals a new pain control pathway from the cortex to the cerebellum crucial to placebo analgesia 鈥� when the expectation of pain relief leads to pain alleviation without a therapeutic intervention, such as with …

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Tag: neuroscience

The unexpected role of a pathogen-sensing immune protein in the brain

Researchers create gene therapy with potential to treat peripheral pain conditions

Fall 2024 Seminar Series – Kristy Welshhans, PhD

Neuronal survival: from the brink of death

Making the connection between sleep and autism

Scientists discover brain circuits for placebo effect pain relief