Monday – FUSION: Leo Bondel, Katie Holmes, & Jake Roetcisoender
G202 MBRB 111 Mason Farm Rd, Chapel HillLeo Bondel (Zylka lab) Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome Katie Holmes聽(Baldwin聽lab) White matter astrocytes maintain … Read more