Ian McCabe (Yeh lab) Identifying two clinically relevant populations of CAFs in PDAC: tumor promoting (proCAF) and tumor restrictive (restCAF) These CAF subtypes are distributed spatially and may play distinct functional roles Mark Hazelbaker (Bear lab) The Arp2/3 complex is required for the turnover of clathrin plaques ACK regulates the recruitment of the Arp2/3 complex … Read more
David Rocco (Bergmeier lab) Elucidating a novel pathway for platelet activation Understanding how this pathway contributes to platelet adhesion under arterial shear stress Andrew Kennedy (Thaxton lab) ER sheet dynamics are distended in T cells in solid cancers Balancing ER sheets and tubules may protect T cells from disturbed ER dynamics in solid tumors
Kimberly Lukasik (Gupton lab) TRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma Emily Bulik-Sullivan (Randell lab) Elucidating the mechanism of ENaC activity reduction by CC-90009 This mechanism, and CC-90009鈥檚 capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis
