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X-ORIGINAL-URL:/cellbiophysio
X-WR-CALDESC:Events for Department of Cell Biology and Physiology
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TZID:America/New_York
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TZOFFSETFROM:-0500
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DTSTART:20250309T070000
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DTSTART:20251102T060000
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250217T123000
DTEND;TZID=America/New_York:20250217T133000
DTSTAMP:20250508T180209
CREATED:20250106T185735Z
LAST-MODIFIED:20250217T143358Z
UID:10000434-1739795400-1739799000@www.med.unc.edu
SUMMARY:Monday – FUSION: Kimberly Lukasik & Emily Bulik-Sullivan
DESCRIPTION:Kimberly Lukasik (Gupton lab) \n\n\n\nTRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma\n\n\n\n  \n\n\n  \n\n\n \n\n\nEmily Bulik-Sullivan (Randell lab) \n\n\n\nElucidating the mechanism of ENaC activity reduction by CC-90009\nThis mechanism\, and CC-90009’s capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-kimberly-lukasik-emily-bulik-sullivan/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250303T123000
DTEND;TZID=America/New_York:20250303T133000
DTSTAMP:20250508T180209
CREATED:20250106T214648Z
LAST-MODIFIED:20250226T191340Z
UID:10000441-1741005000-1741008600@www.med.unc.edu
SUMMARY:Monday - FUSION: Gabby Bais & Sherry Hsu
DESCRIPTION:Gabby Bais (Giudice lab) \n\n\n\nFXR1 may regulate the translation of many cardiomyocyte-specific proteins\nExpression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart\n\n\n\n  \n\n\n  \n\n\n \n\n\nSherry Hsu (Cohen lab) \n\n\n\nTubulin acetylation and polyglutamylation increase early in neuronal differentiation\, exhibit distinct distributions\, and are important for maintaining neuronal morphology\nTubulin acetylation regulates lysosome morphology and its contacts with the endoplasmic reticulum and mitochondria\, highlighting its role in lysosomal function during neuronal differentiation\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-gabby-bais-sherry-hsu/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250324T123000
DTEND;TZID=America/New_York:20250324T133000
DTSTAMP:20250508T180209
CREATED:20250106T215012Z
LAST-MODIFIED:20250327T145529Z
UID:10000442-1742819400-1742823000@www.med.unc.edu
SUMMARY:Monday - FUSION: Henry Uchenna\, Meghan Anderman\, & Ashlyn Laidman
DESCRIPTION:Henry Uchenna (Maddox lab) \n\n\n\nCapping Protein depletion accelerates furrowing and cytokinesis\, likely due to increased F-actin in the contractile ring\nIt also disrupts spindle dynamics\, potentially through effects on the dynein-dynactin complex\n\n\n\n  \n\n\n  \n\n\n \n\n\nMeghan Anderman (McCauley lab) \n\n\n\nUsing human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis\nAssessing the general role of CFTR in GI development and function\n\n\n\n  \n\n\n  \n\n\n \n\n\nAshlyn Laidman (Bressan lab) \n\n\n\nTesting different hypotheses to figure out what cues are directing the stereotyped collective cell migration of the epicardium across the myocardium during development\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-henry-uchenna-meghan-anderman-ashlyn-laidman/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250331T123000
DTEND;TZID=America/New_York:20250331T133000
DTSTAMP:20250508T180209
CREATED:20250106T192312Z
LAST-MODIFIED:20250327T145653Z
UID:10000437-1743424200-1743427800@www.med.unc.edu
SUMMARY:Monday - FUSION: Leo Bondel\, Katie Holmes\, & Jake Roetcisoender
DESCRIPTION:Leo Bondel (Zylka lab) \n\n\n\nOur goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons\, which allow for installation of a Poly(A) signal with cytosine base editors\nThese edits have the potential to restore UBE3A expression\, making this an attractive therapeutic strategy for Angelman Syndrome\n\n\n\n  \n\n\n  \n\n\n \n\n\nKatie Holmes (Baldwin lab) \n\n\n\nWhite matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct\nWhite matter astrocytes take longer to mature than other astrocytes\n\n\n\n  \n\n\n  \n\n\n \n\n\nJake Roetcisoender (O’Brien lab) \n\n\n\nVascular smooth muscle cells impact nerve development in the kidney\n\n\n\n 
URL:/cellbiophysio/event/14558/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250407T123000
DTEND;TZID=America/New_York:20250407T133000
DTSTAMP:20250508T180209
CREATED:20250331T205623Z
LAST-MODIFIED:20250401T223410Z
UID:10000443-1744029000-1744032600@www.med.unc.edu
SUMMARY:Spring 2025 Seminar Series – Cocoa T. Dixon\, PhD
DESCRIPTION:Cocoa T. Dixon\, PhD \n\n\n\n\nAssociate Department Head\, Life Sciences \n\n\nWake Technical Community College \n\n\nTalk focus \n\n\nBeyond the lecture hall: shaping a career in community college teaching \n\n\n\n\n\n\n\n\nFaculty host \n\n\nNatasha Snider\, PhD \n\n\n  \n\n\n\n\n\n\n\n\n\n\nMore about the speaker  \nDr. Dixon is a passionate and innovative educator deeply committed to promoting and enhancing student success in higher education. With nearly two decades of teaching and training experience across diverse educational settings\, she has a proven track record in leading curriculum development\, instructional enhancement\, and fostering holistic student success. \nCurrently\, serving as the Associate Department Head of Life Sciences at Wake Technical Community College\, Dr. Dixon oversees a wide range of responsibilities including faculty recruitment\, development\, and performance management. In addition to her administrative responsibilities\, she plays a pivotal role in fostering professional growth across the institution\, driving strategic initiatives that contribute to the holistic development of both students and faculty. \nDr. Dixon holds a Bachelor of Science in Biology from Shaw University\, a Master of Science in Biology from North Carolina Central University\, a post-graduate certificate in Public Health Concepts from the University of North Carolina Chapel Hill\, and a Ph.D. in Educational Leadership\, Policy\, and Human Development from North Carolina State University.
URL:/cellbiophysio/event/spring-2025-seminar-series-cocoa-t-dixon-phd/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:Invited speaker seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250414T123000
DTEND;TZID=America/New_York:20250414T133000
DTSTAMP:20250508T180209
CREATED:20250331T210605Z
LAST-MODIFIED:20250401T223458Z
UID:10000444-1744633800-1744637400@www.med.unc.edu
SUMMARY:Spring 2025 Seminar Series – Sergiu Pasca\, MD
DESCRIPTION:Sergiu Pasca\, MD \n\n\n\n\nKenneth T. Norris\, Jr. Professor\, Psychiatry & Behavioral Sciences \n\n\nStanford University \n\n\nResearch focus \n\n\nUnderstanding human brain assembly and the molecular mechanisms that lead to neuropsychiatric disease using neural organoids \n\n\n\n\n\n\n\n\nFaculty host \n\n\nGrégory Scherrer\, PharmD\, PhD \n\n\n  \n\n\n\n\n\n\n\n\n\n\nMore about the speaker  \nTrained as a physician in Romania\, Dr. Sergiu Pasca\, came for postdoctoral training at Stanford in 2009 where he developed some of the initial in vitro models of disease by deriving neurons from skin cells taken from patients with genetic brain disorders. His lab has afterwards introduced the use of instructive signals for reproducibly deriving self-organizing 3D cellular structures known as regionalized neural organoids or spheroids. To gain access to complex cellular interactions in the human brain\, his research group also pioneered a modular system to study human neural circuits in preparations named assembloids.
URL:/cellbiophysio/event/spring-2025-seminar-series-sergiu-pasca-md/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:Invited speaker seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250421T123000
DTEND;TZID=America/New_York:20250421T133000
DTSTAMP:20250508T180209
CREATED:20250106T193034Z
LAST-MODIFIED:20250415T183138Z
UID:10000438-1745238600-1745242200@www.med.unc.edu
SUMMARY:Monday - FUSION: Jack Bennett\, Lauren Griffith\, & Shenice Harrison
DESCRIPTION:Jack Bennett (Cook lab) \n\n\n\nIntracellular pH can be manipulated by inhibiting ion transporters\, and these changes can be measured by flow cytometry\npH manipulations may alter cell cycle progression\, arresting cells in the G1 phase of the cell cycle\n\n\n\n  \n\n\n  \n\n\n \n\n\nLauren Griffith (Williams lab) \n\n\n\nExplore how integrin-β1 and its adaptor protein Talin loss-of function affects oriented cell divisions and telophase correction in fixed tissue and live imaging\nExplore how integrin-β1 and its adaptor protein Talin loss-of function impacts basal cell delamination\n\n\n\n  \n\n\n  \n\n\n \n\n\nShenice Harrison (Edwards lab) \n\n\n\nImpaired myristoylation disrupts sarcomere organization and reduces sarcomere length in embryonic cardiomyocytes\nOptimizing a metabolic labeling strategy to identify the myristoylated cardiac proteins required for proper sarcomere assembly\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-katie-holmes-lauren-griffith-shenice-harrison/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250428T123000
DTEND;TZID=America/New_York:20250428T133000
DTSTAMP:20250508T180209
CREATED:20250106T210736Z
LAST-MODIFIED:20250424T133653Z
UID:10000439-1745843400-1745847000@www.med.unc.edu
SUMMARY:Monday – FUSION: Michelle LaBella & Mady Chlebowski
DESCRIPTION:Michelle LaBella (Yeh lab) \n\n\n\nTNIK is required to restrain tumor invasion in PDAC\n\nClear difference in mechanism when compared to colorectal/lung cancer\n\n\nTNIK is a newly identified regulator of PLAT\, tPA expression and ECM modulation through fibrin degradation\nNew mechanism for PDAC invasion and metastasis\, may be what restrains classical tumors\n\n\n\n  \n\n\n  \n\n\n \n\n\nMady Chlebowski (Shiau & Chen labs) \n\n\n\nDistinct neuroimmune and other cell-cell interactions may serve as early signatures of neurodegeneration prior to overt morphological cell death\nThis holds promise for early detection or intervention of neurodegenerative diseases\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-michelle-labella-mady-chlebowski/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250505T123000
DTEND;TZID=America/New_York:20250505T133000
DTSTAMP:20250508T180209
CREATED:20250106T211516Z
LAST-MODIFIED:20250501T165046Z
UID:10000440-1746448200-1746451800@www.med.unc.edu
SUMMARY:Monday: FUSION - Anna Beeson & Vickie Williams
DESCRIPTION:Anna Beeson (Caron lab) \n\n\n\nAdrenomedullin robustly increases both mouse fertility and pinopode formation\nAlternative model systems are allowing us to interrogate pinopode formation in novel ways\n\n\n\n  \n\n\n  \n\n\n \n\n\nVickie Williams (Cohen lab) \n\n\n\nDimerization fluorescent proteins are a useful tool that can show increased ER-LD contacts under conditions of lipid droplet biogenesis\nDimerization-dependent fluorescent proteins can modulate LD size when used to induce ER-LD contact sites\n\n\n\n 
URL:/cellbiophysio/event/monday-fusion-anna-beeson-vickie-williams/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
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