BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Department of Cell Biology and Physiology - ECPv6.11.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:/cellbiophysio X-WR-CALDESC:Events for Department of Cell Biology and Physiology REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20250309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20251102T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20250303T123000 DTEND;TZID=America/New_York:20250303T133000 DTSTAMP:20250511T084332 CREATED:20250106T214648Z LAST-MODIFIED:20250226T191340Z UID:10000441-1741005000-1741008600@www.med.unc.edu SUMMARY:Monday - FUSION: Gabby Bais & Sherry Hsu DESCRIPTION:Gabby Bais (Giudice lab) \n\n\n\nFXR1 may regulate the translation of many cardiomyocyte-specific proteins\nExpression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart\n\n\n\n  \n\n\n  \n\n\n \n\n\nSherry Hsu (Cohen lab) \n\n\n\nTubulin acetylation and polyglutamylation increase early in neuronal differentiation\, exhibit distinct distributions\, and are important for maintaining neuronal morphology\nTubulin acetylation regulates lysosome morphology and its contacts with the endoplasmic reticulum and mitochondria\, highlighting its role in lysosomal function during neuronal differentiation\n\n\n\n  URL:/cellbiophysio/event/monday-fusion-gabby-bais-sherry-hsu/ LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill CATEGORIES:FUSION Seminar Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20250324T123000 DTEND;TZID=America/New_York:20250324T133000 DTSTAMP:20250511T084332 CREATED:20250106T215012Z LAST-MODIFIED:20250327T145529Z UID:10000442-1742819400-1742823000@www.med.unc.edu SUMMARY:Monday - FUSION: Henry Uchenna\, Meghan Anderman\, & Ashlyn Laidman DESCRIPTION:Henry Uchenna (Maddox lab) \n\n\n\nCapping Protein depletion accelerates furrowing and cytokinesis\, likely due to increased F-actin in the contractile ring\nIt also disrupts spindle dynamics\, potentially through effects on the dynein-dynactin complex\n\n\n\n  \n\n\n  \n\n\n \n\n\nMeghan Anderman (McCauley lab) \n\n\n\nUsing human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis\nAssessing the general role of CFTR in GI development and function\n\n\n\n  \n\n\n  \n\n\n \n\n\nAshlyn Laidman (Bressan lab) \n\n\n\nTesting different hypotheses to figure out what cues are directing the stereotyped collective cell migration of the epicardium across the myocardium during development\n\n\n\n  URL:/cellbiophysio/event/monday-fusion-henry-uchenna-meghan-anderman-ashlyn-laidman/ LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill CATEGORIES:FUSION Seminar Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20250331T123000 DTEND;TZID=America/New_York:20250331T133000 DTSTAMP:20250511T084332 CREATED:20250106T192312Z LAST-MODIFIED:20250327T145653Z UID:10000437-1743424200-1743427800@www.med.unc.edu SUMMARY:Monday - FUSION: Leo Bondel\, Katie Holmes\, & Jake Roetcisoender DESCRIPTION:Leo Bondel (Zylka lab) \n\n\n\nOur goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons\, which allow for installation of a Poly(A) signal with cytosine base editors\nThese edits have the potential to restore UBE3A expression\, making this an attractive therapeutic strategy for Angelman Syndrome\n\n\n\n  \n\n\n  \n\n\n \n\n\nKatie Holmes (Baldwin lab) \n\n\n\nWhite matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct\nWhite matter astrocytes take longer to mature than other astrocytes\n\n\n\n  \n\n\n  \n\n\n \n\n\nJake Roetcisoender (O’Brien lab) \n\n\n\nVascular smooth muscle cells impact nerve development in the kidney\n\n\n\n  URL:/cellbiophysio/event/14558/ LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill CATEGORIES:FUSION Seminar Series END:VEVENT END:VCALENDAR