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Monday – FUSION: Leo Bondel, Katie Holmes, & Jake Roetcisoender
March 31 @ 12:30 pm - 1:30 pm
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Leo Bondel ( lab)
- Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors
- These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome
Katie Holmes (BaldwinÌý±ô²¹²ú)
- White matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct
- White matter astrocytes take longer to mature than other astrocytes
Jake Roetcisoender ( lab)
- Vascular smooth muscle cells impact nerve development in the kidney
