The labs of Mark Zylka, Ben Major, both in the Dept. of Cell Biology and Physiology, and Mike Emanuele identified a link between the E3 ubiquitin ligase Ube3a, the proteasome, and Wnt signaling. This collaboration harnessed the Zylka labs expertise at studying an autism-linked Ube3a mutation, the Major labs expertise with proteomics and Wnt signaling, and the Emanuele鈥檚 lab expertise at identifying ubiquitinated substrates.
