A team of researchers led by Kathleen Caron investigating new therapeutic approaches for treating debilitating migraines in women is the first in the School of Medicine to receive a prestigious Sprint for Women鈥檚 Health Award.
The (ARPA-H) award funds research that addresses critical unmet challenges in women鈥檚 health, champions transformative innovations, and tackles health conditions that uniquely or disproportionately affect women. A team of researchers led by , the Chair of the Department of Cell Biology and Physiology, will receive $3 million in funding over two years through the Sprint for Women鈥檚 Health spark track for early-stage research investigating 鈥淔emale Lymphatic GPCR Therapeutics for Migraine Treatment鈥� (FLyGT).
The team brings together an interdisciplinary approach to illuminate the genetic and pharmacological differences in meningeal lymphatics between the sexes. With co-investigators , , and , the FLyGT team will use forward genetic screens and innovative drug target discovery to define new avenues for migraine treatment. Clinical studies facilitated by cutting-edge brain imaging with and Yen-Yu Ian Shih聽will evaluate whether some types of anti-migraine medications might be beneficial in maintaining lymphatic function during migraine.
鈥淢igraine is a debilitating and chronic condition,鈥� said Caron. 鈥淒efining new and better treatment strategies that target the meningeal lymphatics will lead to a better quality of life and overall brain health for women who suffer from migraine.鈥�
ARPA-H sought solutions within in women鈥檚 health and received an unprecedented response of submissions. ARPA-H in February, with First Lady Jill Biden announcing the funding as the first major deliverable from the White House Initiative on Women鈥檚 Health Research.
The ARPA-H Sprint for Women鈥檚 Health is conducted in collaboration with the聽听辞蹿听, the agency鈥檚 nationwide health innovation network that connects people, innovators, and institutions to accelerate better health outcomes for everyone. The lead study researchers will work with an ARPA-H Program Manager and the Investor Catalyst Hub over two years to develop their proposed solution, receiving milestone-based payments aligned to research activities and performance objectives.
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