July 2, 2024
The International Society on Thrombosis and Haemostasis (ISTH), an international medical and scientific professional Society advancing the understanding, prevention, diagnosis, and treatment of thrombosis and hemostasis, announces the ISTH 2024 Congress will be hosted in Bangkok, Thailand for the first time on June 22-26, 2024, at the Queen Sirikit National Convention Center. The ISTH Congress …
July 2, 2024
Melissa Caughey PhD received an NIH grant related to sickle cell disease: “Chronic dehydration in sickle cell disease: an actionable biomarker to prevent vaso-occlusive episodes” The National Institutes of Health is the largest public funder of biomedical research in the world. In fiscal year 2022, NIH invested most of its $45 billion appropriations in research …
June 10, 2024
A manuscript entitled 鈥淒isease severity drives thrombosis risk in women with sickle cell disease in a single-center retrospective study鈥� was recently accepted in Research and Practice in Thrombosis and Haemostasias. The research was initiated by Jennifer Light, MD, during her fellowship in the 黑料网 Pediatrics Division of Hematology and Oncology. She performed her basic research …
June 7, 2024
A new MPI NIH R01 was awarded to Alisa Wolberg, PhD and Karin Leiderman, PhD of University of North Carolina at Chapel Hill School of Medicine, entitled: 鈥淚nterdisciplinary Approach to Elucidate Modifiers of Bleeding Phenotype in Factor XI Deficiency.鈥� PROJECT SUMMARY Congenital聽deficiency聽of plasma clotting聽factor聽(F)XI聽is an autosomal disorder. Whereas some individuals are asymptomatic (non-bleeders), others have …
June 7, 2024
Jamie Madrigal, Mac Monroe, Suzanne Sindi, Karin Leiderman, from The University of North Carolina at Chapel Hill School of Medicine, had a new paper published in Mathematical Biosciences. 鈥淢odeling the Distribution of Enzymes on Lipid Vesicles: A Novel Framework for Surface-Mediated Reactions in Coagulation鈥�. Abstract Blood coagulation is a network of biochemical reactions wherein dozens …
June 5, 2024
Abigail Ballard-Kordeliski, Robert H. Lee, Ellen Clelia O’Shaughnessy, Paul Y. Kim, Summer R Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David Adalsteinsson, Wolfgang Bergmeier all of University of North Carolina at Chapel Hill had their research published in the journal Blood. Title: “4D intravital imaging identifies platelets as the predominant …
December 13, 2019
I am a clinical hematologist with an academic focus and national leadership role in the field of vascular anomalies. I built and co-directed the Vascular Anomalies Program at Vanderbilt University Medical Center and served as Associate Clinical Director of the Comprehensive Vascular Anomalies Program and Co-Director of the Pediatric Hereditary Hemorrhagic Telangiectasia Program at the …
December 10, 2019
I have been committed to building a strong translational research program to address novel challenges and questions related to blood and renal pathophysiology in rodents and humans. My work provided strong pre-clinical evidence that endothelin system significantly contributes to sickle cell renal pathophysiology. My collaborative efforts with Dr. Lebensburger identified predictors of the onset of long-term kidney insufficiency and uncovered clear sex differences in the rate of sickle cell nephropathy progression in patients and murine model of sickle cell disease. My current research focuses on functional significance of iron homeostasis in chronic kidney disease (CKD), in particular, the mechanisms of renal iron handling in progressive sickle cell nephropathy. Currently, my lab has three on-going research projects: 1) elucidating molecular mechanisms of endothelin system-mediated renal iron handling in murine models of iron overload; 2) mechanisms of renal dysfunction in sickle cell trait, 3) identifying risk factors for early progression to CKD in sickle cell pediatric patients.