{"id":5,"date":"2017-06-21T15:13:49","date_gmt":"2017-06-21T15:13:49","guid":{"rendered":"https:\/\/med-template.sites.unc.edu\/home\/"},"modified":"2025-01-03T12:42:28","modified_gmt":"2025-01-03T17:42:28","slug":"home","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/","title":{"rendered":"Home"},"content":{"rendered":"

Why do viral infections lead to increased tissue factor (TF) expression?\u00a0 What are the mechanisms of <\/em>viral infection-induced TF expression? <\/em>Is the TF induction a wanted response by the virus? <\/em>Or is the TF induction the host’s own protective innate immune response? <\/em>What happens when the TF induction is impaired? <\/em>What happens when the TF induction is uncontrolled? Does TF act as initiator of coagulation or signaling? When TF is the start; what is the end product of the pathway? If signaling is involved, is it mediated through protease-activated receptors (PARs)? Which role has PAR4 in viral infections?<\/em><\/p>\n

These are questions the Antoniak Lab wants to answer. We focus on pulmonary viral infections like influenza A virus and coronaviruses and on cardiac infections like viral myocarditis. We want to understand the life-supporting side of TF in hemostasis but also life threatening-side of TF in thrombosis. How can we support the good and limit the bad?<\/p>\n

If you are interested in understanding the secrets of life and you want to help and want to be a part of something special; Become a lab member; Be a collaborator; Be a supporter; and Be an ally. Get in touch with us to start the journey.<\/a><\/p>\n

#KeepMovingForward<\/p>\n

#LifeInPrime<\/p>\n

\"ºÚÁÏÍø-Chapel<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Why do viral infections lead to increased tissue factor (TF) expression?\u00a0 What are the mechanisms of viral infection-induced TF expression? Is the TF induction a wanted response by the virus? Or is the TF induction the host’s own protective innate immune response? What happens when the TF induction is impaired? What happens when the TF … Read more<\/a><\/p>\n","protected":false},"author":1369,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/front-page.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/users\/1369"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":43,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":2522,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/pages\/5\/revisions\/2522"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/antoniaklab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}