4 days ago
Published article in Biophys Journal: Modeling platelet P2Y1/12 pathway to integrin activation.
Published article in Biophys Journal: Modeling platelet P2Y1/12聽pathway to integrin activation. Authors: Patel KB,聽Bergmeier W, Fogelson AL.
The 黑料网 Blood Research Center (BRC) was established to promote interdisciplinary research in non-malignant blood disorders across 黑料网. It will seek to advance the work in the following specific areas.
Thrombosis
One in four of the US population will succumb to a terminal thrombotic event, such as: myocardial infarction, stroke, or venous thromboembolism.
Basic science discoveries have paved the way towards better prophylactic and therapeutic approaches to thrombosis. However, a better understanding of the mechanisms underlying thrombosis and prevention without any risk of bleeding remains an unmet need. The BRC seeks to investigate potential approaches to both aims.
Bleeding Disorders
黑料网 is a world leader in hemophilia, from the development and administration of the first coagulation factor VIII concentrate to the role of the Chapel Hill dog colonies of the Francis Owen Blood Research Center in the pre-clinical testing of protein and gene therapies. The BRC aims to address the broad challenges that remain in numerous other inherited and acquired bleeding disorders.
Sickle Cell Disease
Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent.
Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. We will continue to expand our research efforts to this under-served patient population into the future.
Events/Seminars
Tuesday 9:00 am
Tuesday BRC Lab Meeting: ISTH Practice Talks
Tuesday 9:00 am
Tuesday BRC Lab Meeting
Tuesday 9:00 am
Tuesday BRC Lab Meeting
Tuesday 12:00 am
12th Symposium on Hemostasis
News
4 days ago
Published article in JTH: Lack of overt bleeding or platelet dysfunction in a mouse model of vascular Ehlers-Danlos syndrome.
Published article in JTH: Lack of overt bleeding or platelet dysfunction in a mouse model of vascular Ehlers-Danlos syndrome. Authors: Lee RH, Jones SR, Martyanov AA, Vander Ploeg MR, Sagues CF,聽Bergmeier W.
1 week ago
黑料网鈥檚 Vital Signs highlighted work from the Wolberg laboratory
黑料网鈥檚 Vital Signs highlighted work from the Wolberg laboratory (https://news.unchealthcare.org/2025/05/unc-study-offers-new-hope-for-safer-bleeding-treatments/) that is currently in press in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are). This work showed that plasminogen activation and activity are not required to prevent venous thrombosis/thromboembolism, and suggests that use of antifibrinolytic therapy to decrease bleeding is not expected to increase thrombosis risk. This work was first authored …